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The map label for this gene is rppH

Identifier: 17547536

GI number: 17547536

Start: 3031003

End: 3031719

Strand: Direct

Name: rppH

Synonym: RSc2817

Alternate gene names: 17547536

Gene position: 3031003-3031719 (Clockwise)

Preceding gene: 17547531

Following gene: 17547537

Centisome position: 81.56

GC content: 65.27

Gene sequence:

>717_bases
ATGCTCGATCGTGAAGGCTTCCGCCCGAACGTCGGCATCATCCTCATCAACGCAAGAAACGAGGTGTTCTGGGGCAAGCG
TATCGGCGAGCACTCCTGGCAGTTTCCACAAGGCGGCATCAAGTACGGCGAAACGCCCGAACAGGCGATGTACCGCGAAC
TGCACGAAGAAGTCGGCCTGTTGCCAGAACACGTCCGGATCGTCGGTCGCACACGCGACTGGCTGCGGTATGAGGTGCCG
GACAAGTTCATCCGCCGCGAGATCCGCGGCCACTACCGGGGCCAGAAACAGATCTGGTTCCTGCTGCGCATGGTGGGCCG
CGATTGCGATATCCAGTTGCGCGCCACCGAGCATCCGGAGTTCGATGCCTGGCGCTGGAGCCAGTACTGGGTGCCGCTCG
ATGCCGTGATCGAGTTCAAGCGCGAGGTGTATCAGATGGCGCTGTCGGAGCTGTCGCGCTTCGTGCAGCGGTCCCATCGG
GCGCCGCTGTCGCCGTACGGGCGCGGCGGACCGCACCGCGAGCGCGACGGACGCGACAACCGCGCCGGCGGCCAGGCCGG
CCGGAACGACCAGAACACGCGCGGCCAGCGTCAGCCGCCGACACTGATGGTCACCACATCGACGGTCATCGTCGAAACCG
TGATCACGTCCCGGCCCGCCGCGCAGCCCATCGACTCTTCCAACCCTGACGACACCCCGTCCAAGGACTCTCTGTGA

Upstream 100 bases:

>100_bases
CAGGAGGCGCGAGTGAGCGGCAACATTGCGGCATCCGATAACAGCAGGACGGCAGGCCGCTCTATAATCGGCGTAATTCT
AAAGTATTCGAGGTGCAGTC

Downstream 100 bases:

>100_bases
CTGTGATGACGACGACACGTGGAGCGCGCCGCGCTCTCGTGCCGCTCGCGCTGGCGGCTACGCTGGCGCTGACGGCATGT
GGCCACAACCGCACCGGCGA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPEFDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHR
APLSPYGRGGPHRERDGRDNRAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL

Sequences:

>Translated_238_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPEFDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHR
APLSPYGRGGPHRERDGRDNRAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL
>Mature_238_residues
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGLLPEHVRIVGRTRDWLRYEVP
DKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPEFDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHR
APLSPYGRGGPHRERDGRDNRAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=175, Percent_Identity=46.8571428571429, Blast_Score=181, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_RALSO (Q8XVL3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520938.1
- ProteinModelPortal:   Q8XVL3
- SMR:   Q8XVL3
- GeneID:   1221664
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2817
- NMPDR:   fig|267608.1.peg.2817
- HOGENOM:   HBG302451
- OMA:   DIQLRAT
- ProtClustDB:   PRK00714
- BioCyc:   RSOL267608:RSC2817-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 27746; Mature: 27746

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGL
CCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPE
CHHHHHHHCCCHHHHEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHRAPLSPYGRGGPHRERDGRDN
CCCEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL
CCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGL
CCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPE
CHHHHHHHCCCHHHHEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHRAPLSPYGRGGPHRERDGRDN
CCCEECCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL
CCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852