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The map label for this gene is ffh [H]

Identifier: 17547530

GI number: 17547530

Start: 3024633

End: 3026063

Strand: Direct

Name: ffh [H]

Synonym: RSc2811

Alternate gene names: 17547530

Gene position: 3024633-3026063 (Clockwise)

Preceding gene: 17547521

Following gene: 17547531

Centisome position: 81.39

GC content: 67.85

Gene sequence:

>1431_bases
ATGCTGGATAACCTGACCCAACGGCTCGCGCGGGTGGTCAAGACCATGCGCGGCGAGGCGCGCCTGACCGAGGCCAACAC
CGCCGAAATGCTGCGCGAGGTTCGCCTGGCGCTGCTCGAAGCCGACGTGGCGCTGCCGGTCGTGCGCGAGTTCATCGCCC
GCATCAAGGAAAAAGCGCTCGGCGAGGAAGTCATCACCAGCCTGTCGCCGGGCCAGGCACTGGTCGGCATCGTGCAGCGC
GAGCTGACCGCCATCATCGGCGGCGAAGAGGCGGTTGCCCCCGCCCCGGCCGGCATACCCGCCGGCCTGCCCATCGGCCG
CGCCGCCGAGCTGAACCTCAACGTCCAGCCGCCCGCGGTCATCCTGATGGCCGGCCTGCAGGGCGCCGGCAAGACCACCA
CCGTCGGCAAGCTGGCCAAGTGGCTCAAGGAGAACAAGAAGAAGAAAGTGCTGACGGTGTCGTGCGACGTCTACCGACCC
GCCGCCATCGCACAGCTCAAGACCGTGTCGGAGCAGGTCGGCGCGGACTTCTTCCCGTCGCAGCCCGAACAGAAGCCGGT
CGACATCGCCGCCGCCGCGCTCGACTGGGCCAAGAAGCATTACCACGACGTGCTGATCGTCGACACGGCCGGGCGCCTGG
GCATCGACGAAGCGATGATGCAGGAGATCGCCGCGCTGCACGCCACGCTCAAGCCGGCCGAAACGCTGTTCGTGGTCGAC
GCGATGCTCGGCCAGGACGCCGTCAATACCGCCAAGGCCTTCAACGACGCCCTGCCCCTGACCGGCGTGGTGCTGACCAA
GCTCGACGGCGACGCGCGCGGCGGCGCGGCCCTGTCGGTGCGGCACATCACCGGCAAGCCGATCAAGTTCGTCGGCGTGG
CGGAAAAGCTCGATGGGCTGGAGCCGTTCTACCCCGACCGCATGGCCCAGCGCATCCTGGGCATGGGCGACATCCTCGCG
CTGGTCGAGGAAGCCCAGCGCGGCGTCGACATGGAACAGGCGCAGAAGCTCGCCGCCAAGATCAAGAAGACCGGCGGCTT
CGACCTGGAAGACTTCAAGGCCCAGATCGGCCAGATGAAGAAGATGGGCGGCCTGGGGCAACTGATCGACAAGCTGCCGG
CGCAGTTCGCCCAGCGAGCGCAGGGCGCCAACATGGACCAGGCCGACAAGCAGGTGCGCCGCATGGAAGGCATCATCAAC
AGCATGACGCCCGCGGAGCGCGCCAAGCCCGAGCTGATCAAGGCCAGCCGCAAGCGCCGCATCGCCGCCGGCGCCGGCGT
GCCGGTGCAGGAGGTCAACCGCCTGCTCAACCAGTTCGAGCAGATGCAGACCATGATGAAGAAGCTCAAGGGCGGCGGCA
TGATGAAGATGATGCGCGCCATGGGCGGCCTCAAGGGCGGCATGAAGGGACTGCTTCCCGGCGGCCGCTGA

Upstream 100 bases:

>100_bases
TTCCGGAGGCGCACGGCATCGCGTGGCGGCCTCCGCAACGTTGCCGGATCCCCGTTGATTCCATTGCTTTCGTCTCCGAT
CACTCCCTGGATTTGCTGTC

Downstream 100 bases:

>100_bases
GCCCGTCCGCGATCCGATTGACCAGAAACGTTTCACCGACCGATACGATGCTGAGCGCAGAACAGGCCCGCGAACTGTGG
GCCAACTCCGAGGAAATCGT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLALLEADVALPVVREFIARIKEKALGEEVITSLSPGQALVGIVQR
ELTAIIGGEEAVAPAPAGIPAGLPIGRAAELNLNVQPPAVILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRP
AAIAQLKTVSEQVGADFFPSQPEQKPVDIAAAALDWAKKHYHDVLIVDTAGRLGIDEAMMQEIAALHATLKPAETLFVVD
AMLGQDAVNTAKAFNDALPLTGVVLTKLDGDARGGAALSVRHITGKPIKFVGVAEKLDGLEPFYPDRMAQRILGMGDILA
LVEEAQRGVDMEQAQKLAAKIKKTGGFDLEDFKAQIGQMKKMGGLGQLIDKLPAQFAQRAQGANMDQADKQVRRMEGIIN
SMTPAERAKPELIKASRKRRIAAGAGVPVQEVNRLLNQFEQMQTMMKKLKGGGMMKMMRAMGGLKGGMKGLLPGGR

Sequences:

>Translated_476_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLALLEADVALPVVREFIARIKEKALGEEVITSLSPGQALVGIVQR
ELTAIIGGEEAVAPAPAGIPAGLPIGRAAELNLNVQPPAVILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRP
AAIAQLKTVSEQVGADFFPSQPEQKPVDIAAAALDWAKKHYHDVLIVDTAGRLGIDEAMMQEIAALHATLKPAETLFVVD
AMLGQDAVNTAKAFNDALPLTGVVLTKLDGDARGGAALSVRHITGKPIKFVGVAEKLDGLEPFYPDRMAQRILGMGDILA
LVEEAQRGVDMEQAQKLAAKIKKTGGFDLEDFKAQIGQMKKMGGLGQLIDKLPAQFAQRAQGANMDQADKQVRRMEGIIN
SMTPAERAKPELIKASRKRRIAAGAGVPVQEVNRLLNQFEQMQTMMKKLKGGGMMKMMRAMGGLKGGMKGLLPGGR
>Mature_476_residues
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLALLEADVALPVVREFIARIKEKALGEEVITSLSPGQALVGIVQR
ELTAIIGGEEAVAPAPAGIPAGLPIGRAAELNLNVQPPAVILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRP
AAIAQLKTVSEQVGADFFPSQPEQKPVDIAAAALDWAKKHYHDVLIVDTAGRLGIDEAMMQEIAALHATLKPAETLFVVD
AMLGQDAVNTAKAFNDALPLTGVVLTKLDGDARGGAALSVRHITGKPIKFVGVAEKLDGLEPFYPDRMAQRILGMGDILA
LVEEAQRGVDMEQAQKLAAKIKKTGGFDLEDFKAQIGQMKKMGGLGQLIDKLPAQFAQRAQGANMDQADKQVRRMEGIIN
SMTPAERAKPELIKASRKRRIAAGAGVPVQEVNRLLNQFEQMQTMMKKLKGGGMMKMMRAMGGLKGGMKGLLPGGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=481, Percent_Identity=29.5218295218295, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=361, Percent_Identity=32.1329639889197, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI23308697, Length=204, Percent_Identity=34.3137254901961, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI295424842, Length=204, Percent_Identity=34.3137254901961, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=34.9693251533742, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788963, Length=475, Percent_Identity=63.1578947368421, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1789874, Length=292, Percent_Identity=33.5616438356164, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=454, Percent_Identity=28.8546255506608, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=37.6237623762376, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=426, Percent_Identity=31.2206572769953, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17647949, Length=475, Percent_Identity=30.1052631578947, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24641198, Length=202, Percent_Identity=33.1683168316832, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51079; Mature: 51079

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLALLEADVALPVVREFIARIKEKAL
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVITSLSPGQALVGIVQRELTAIIGGEEAVAPAPAGIPAGLPIGRAAELNLNVQPPAV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHH
ILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQVGADFFPS
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
QPEQKPVDIAAAALDWAKKHYHDVLIVDTAGRLGIDEAMMQEIAALHATLKPAETLFVVD
CCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AMLGQDAVNTAKAFNDALPLTGVVLTKLDGDARGGAALSVRHITGKPIKFVGVAEKLDGL
HHHCCHHHHHHHHHHCCCCHHHHEEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHCCC
EPFYPDRMAQRILGMGDILALVEEAQRGVDMEQAQKLAAKIKKTGGFDLEDFKAQIGQMK
CCCCHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KMGGLGQLIDKLPAQFAQRAQGANMDQADKQVRRMEGIINSMTPAERAKPELIKASRKRR
HCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
IAAGAGVPVQEVNRLLNQFEQMQTMMKKLKGGGMMKMMRAMGGLKGGMKGLLPGGR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDNLTQRLARVVKTMRGEARLTEANTAEMLREVRLALLEADVALPVVREFIARIKEKAL
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVITSLSPGQALVGIVQRELTAIIGGEEAVAPAPAGIPAGLPIGRAAELNLNVQPPAV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHH
ILMAGLQGAGKTTTVGKLAKWLKENKKKKVLTVSCDVYRPAAIAQLKTVSEQVGADFFPS
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCC
QPEQKPVDIAAAALDWAKKHYHDVLIVDTAGRLGIDEAMMQEIAALHATLKPAETLFVVD
CCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AMLGQDAVNTAKAFNDALPLTGVVLTKLDGDARGGAALSVRHITGKPIKFVGVAEKLDGL
HHHCCHHHHHHHHHHCCCCHHHHEEEECCCCCCCCCEEEEEECCCCCEEEEEHHHHHCCC
EPFYPDRMAQRILGMGDILALVEEAQRGVDMEQAQKLAAKIKKTGGFDLEDFKAQIGQMK
CCCCHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KMGGLGQLIDKLPAQFAQRAQGANMDQADKQVRRMEGIINSMTPAERAKPELIKASRKRR
HCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
IAAGAGVPVQEVNRLLNQFEQMQTMMKKLKGGGMMKMMRAMGGLKGGMKGLLPGGR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]