Click here to switch to the map view.

The map label for this gene is pehS [H]

Identifier: 17547527

GI number: 17547527

Start: 3021181

End: 3023229

Strand: Reverse

Name: pehS [H]

Synonym: RSc2808

Alternate gene names: 17547527

Gene position: 3023229-3021181 (Counterclockwise)

Preceding gene: 17547528

Following gene: 17547526

Centisome position: 81.35

GC content: 70.96

Gene sequence:

>2049_bases
ATGATGCGCGACGCTTCCAAGGCGGGCGGTGCCGACGCTGCGGGTGCCGGGGCGTCCGGCATGCGCCTGTGGTCGCGCCT
GAACGCCTGGCGTGCGCTGCGCGCGGTATGGCTGGAGCCCGATCCGCCCGAATTCCAGTGGCGCCTGCTGCGCTACTTCG
CCTTCAGCCGGGCGGCGGTGGCGCTGGTGCTGCTGCTGTTCGTCTCGATCCCCCGCGAGCATGCGAGCGATCTGCCGGCA
CCCGTCGGCGACGCCATGCTCAGCTTGACGCTGCCGTACCTGGCGCTGGCGCTGCTGATCCTGGCGGCGGCGGGGTGGTG
GCGCTCGCGTTTCCAGTTCCGGGTGCGGCTGGACGTGCTGCTGGACCTGCTCTTCCTCGGATTGGCCTATGCGACGCTGT
CGCACCTGTCGGCCAGCGTGGCGATGGTGTTCCTGATGCCGGTGCTGGCGGCCGGCGCGCTGACCAGCCTGTTGTACGCC
CTGTTCACTGCGGCAGTGGCATCGATGGTGGTGCTGGCTGCGCCCTTCCTGCGCATGCTGGGCGATGGCGGGATCGACTC
GGGGCTGGCCTCCGCCGGGCTGTACGGCCTGGTCTACATGATGGCCGCGCTGATGATGTACGGGCTGTCGCACCGGCAGG
TGGCGCAGGAGCGCCTGACGCTGGCCCGCGAGCGCGAGCTGCGCCTGCAGCAGCTGGTGAACCGGCTGATGGTCTATGAC
ATGCAGGACGGCGTGATGCTGGTGCGCGCCGACGGCCGCGTGGTGGCCGCCAATCCCGCCGCGGCGATGCTGCTGGGCGT
GCCGCAGAATGCATTCGTCGGCAGCGGGACCATGTTGTTCGACCTGAAGGACATCCCGCACCTGCATCCGCTGCTGGAAA
CGCTGCGCCAGTTGCTGCGCCGCCGGAACCGGCAGCCGGGCAGCGGCGCCGACGTGGCCGGCGATGACGAGGCCACGCGC
ATCCTCGACCTGCAGCCGATCGCCGCGGGCGGCCGTGCCGCGCTGCGTGCCCGTCTGCGCCTGCGCTTCATCCTGCCGAG
CCTGGCGAACCTGGGCCGCGTCTATATGGATAGCCTGGTCAGCTCGATCGGTCTGGGCCTGCCCGGCGAGGCCGCCGGCG
AGCCGTCGCGTGCGCGCGGCCCCACGGCCGAGACCGTCGCACCGGGCTGGTCCGCCGATGACGAAGTCTTCCTGCGCCAC
GAACTGCACGACACCGTGCTGGTGCACGTGGAGAGCTGGGAGCGCGTGACCGAGCAGGCCCAGCAGGAAAAGCTGGCATC
GATGGGGCGGCTGGTGGCCAGCGTGGCGCACCAGATCCGCAACCCGCTCGCGGCCATCAGCCAGGCGGCCGAACTGCTGG
ACGACCCGGGCGAGGGCGGCGAGCCGGTGCGCCCCGAGGGGCGCGGCGTGGAGACGCGCCTGCTGCGCATCATCCGCGAC
AACGTGCGCCGTCTCGACCAGGTGGTCGCCGATGTCCTGATGCTGTCGCGCCGGCCGCGCGGCGAGCGCGTGCGCGAGCA
GCTTGCGCAGGTGCTGCCCGAGGTGGTGGAGCGCTGGCGTGCCGAGGCGCTGCGCCGTGCGGGCGAGGCCACCGAAATCA
GCGCCGACCTGGTGCGCGTGGCGGTCGACCTGGCGCGGCCGGTGCTGTTCGATCCGGCCCACCTGCAGCAGGTGGTGGGC
AACCTGCTCGACAACGCGCTGCGCTATTGCCGCGGCGTGCCGGGCTCGATCCTGCTGGCGGCCTATCCGCTGGATGACAC
CCACGCCGAACTGGTGATCTGGAACGACGGCCCCGAGGTGTCCGCCGAGCAGCAGCGCAGCCTGTTCGAGCCGTTCTTCA
CCAATGACGCGCAGGGCACCGGGCTCGGTCTCTACATGGCCCGCGAGTTGTGCGGTGCCAACGATGCGCAGATCCGCTAC
GGCGACATCGCGCTCGAATCCTTGCTCGATCGCACCGGAGTGATGACCATGGAGGTGCGCGAGGGCCTGCCGCGCCGCGC
TTTCGTCATCACCCTGATGTTCGACCCACCCGCTGTGCCGGCGGAATGA

Upstream 100 bases:

>100_bases
TCTGCGGCGTGCATGCGCCGCGCACCGGCATGGTGGCCCTGCCTGGCGGGCGCTATCGGTGTGCCGAGCATGCCGACCAG
GCCGACGGCCGGGGCGGCGC

Downstream 100 bases:

>100_bases
GCCGCCAGCCGTTTTTCCGTCCCCCCATGTCCAAAGCTGCCGTCGTTCGCGAACCCATCCTCGTCGTCGATGACGAGGCC
GATCTGCGTGAGCTGCTGGA

Product: transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MMRDASKAGGADAAGAGASGMRLWSRLNAWRALRAVWLEPDPPEFQWRLLRYFAFSRAAVALVLLLFVSIPREHASDLPA
PVGDAMLSLTLPYLALALLILAAAGWWRSRFQFRVRLDVLLDLLFLGLAYATLSHLSASVAMVFLMPVLAAGALTSLLYA
LFTAAVASMVVLAAPFLRMLGDGGIDSGLASAGLYGLVYMMAALMMYGLSHRQVAQERLTLARERELRLQQLVNRLMVYD
MQDGVMLVRADGRVVAANPAAAMLLGVPQNAFVGSGTMLFDLKDIPHLHPLLETLRQLLRRRNRQPGSGADVAGDDEATR
ILDLQPIAAGGRAALRARLRLRFILPSLANLGRVYMDSLVSSIGLGLPGEAAGEPSRARGPTAETVAPGWSADDEVFLRH
ELHDTVLVHVESWERVTEQAQQEKLASMGRLVASVAHQIRNPLAAISQAAELLDDPGEGGEPVRPEGRGVETRLLRIIRD
NVRRLDQVVADVLMLSRRPRGERVREQLAQVLPEVVERWRAEALRRAGEATEISADLVRVAVDLARPVLFDPAHLQQVVG
NLLDNALRYCRGVPGSILLAAYPLDDTHAELVIWNDGPEVSAEQQRSLFEPFFTNDAQGTGLGLYMARELCGANDAQIRY
GDIALESLLDRTGVMTMEVREGLPRRAFVITLMFDPPAVPAE

Sequences:

>Translated_682_residues
MMRDASKAGGADAAGAGASGMRLWSRLNAWRALRAVWLEPDPPEFQWRLLRYFAFSRAAVALVLLLFVSIPREHASDLPA
PVGDAMLSLTLPYLALALLILAAAGWWRSRFQFRVRLDVLLDLLFLGLAYATLSHLSASVAMVFLMPVLAAGALTSLLYA
LFTAAVASMVVLAAPFLRMLGDGGIDSGLASAGLYGLVYMMAALMMYGLSHRQVAQERLTLARERELRLQQLVNRLMVYD
MQDGVMLVRADGRVVAANPAAAMLLGVPQNAFVGSGTMLFDLKDIPHLHPLLETLRQLLRRRNRQPGSGADVAGDDEATR
ILDLQPIAAGGRAALRARLRLRFILPSLANLGRVYMDSLVSSIGLGLPGEAAGEPSRARGPTAETVAPGWSADDEVFLRH
ELHDTVLVHVESWERVTEQAQQEKLASMGRLVASVAHQIRNPLAAISQAAELLDDPGEGGEPVRPEGRGVETRLLRIIRD
NVRRLDQVVADVLMLSRRPRGERVREQLAQVLPEVVERWRAEALRRAGEATEISADLVRVAVDLARPVLFDPAHLQQVVG
NLLDNALRYCRGVPGSILLAAYPLDDTHAELVIWNDGPEVSAEQQRSLFEPFFTNDAQGTGLGLYMARELCGANDAQIRY
GDIALESLLDRTGVMTMEVREGLPRRAFVITLMFDPPAVPAE
>Mature_682_residues
MMRDASKAGGADAAGAGASGMRLWSRLNAWRALRAVWLEPDPPEFQWRLLRYFAFSRAAVALVLLLFVSIPREHASDLPA
PVGDAMLSLTLPYLALALLILAAAGWWRSRFQFRVRLDVLLDLLFLGLAYATLSHLSASVAMVFLMPVLAAGALTSLLYA
LFTAAVASMVVLAAPFLRMLGDGGIDSGLASAGLYGLVYMMAALMMYGLSHRQVAQERLTLARERELRLQQLVNRLMVYD
MQDGVMLVRADGRVVAANPAAAMLLGVPQNAFVGSGTMLFDLKDIPHLHPLLETLRQLLRRRNRQPGSGADVAGDDEATR
ILDLQPIAAGGRAALRARLRLRFILPSLANLGRVYMDSLVSSIGLGLPGEAAGEPSRARGPTAETVAPGWSADDEVFLRH
ELHDTVLVHVESWERVTEQAQQEKLASMGRLVASVAHQIRNPLAAISQAAELLDDPGEGGEPVRPEGRGVETRLLRIIRD
NVRRLDQVVADVLMLSRRPRGERVREQLAQVLPEVVERWRAEALRRAGEATEISADLVRVAVDLARPVLFDPAHLQQVVG
NLLDNALRYCRGVPGSILLAAYPLDDTHAELVIWNDGPEVSAEQQRSLFEPFFTNDAQGTGLGLYMARELCGANDAQIRY
GDIALESLLDRTGVMTMEVREGLPRRAFVITLMFDPPAVPAE

Specific function: Member of the two-component regulatory system pilS/pilR involved in the regulation of the expression of type 4 fimbriae. PilS may function as a membrane-associated protein kinase that phosphorylates pilR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=28.6363636363636, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.9279279279279, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790346, Length=206, Percent_Identity=25.2427184466019, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74549; Mature: 74549

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure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CCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8097014; 10984043 [H]