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The map label for this gene is mutL

Identifier: 17547282

GI number: 17547282

Start: 2772063

End: 2773973

Strand: Direct

Name: mutL

Synonym: RSc2563

Alternate gene names: 17547282

Gene position: 2772063-2773973 (Clockwise)

Preceding gene: 17547281

Following gene: 17547283

Centisome position: 74.59

GC content: 71.17

Gene sequence:

>1911_bases
ATGACTGCCGCCACCCCTGCCCGCCGCCCCATCCGTCCGCTTCCCGACCAGCTGATCAGCCAGATCGCGGCCGGCGAGGT
GGTCGAACGCCCGGCCTCCGTGGTCAAGGAACTGCTCGAGAACGCACTCGACGCCGGCGCCACTCAGCTGCAGATCAAGC
TGGAAGAAGGCGGCGTGCGGCGCATCGCCATCACCGACAACGGCGGAGGCATTCCGGTCGACGAACTGCCGGTCGCGCTG
ATGCGGCACGCGACCAGCAAGATCGGCTCGCTGGAGGAGCTGGAATCGGTGGCGACGCTGGGGTTCCGCGGCGAGGCGCT
GGCATCGATCGCCTCGGTGGCGGAGTTGACGCTCACCTCGCGCACCGCGCAAGACGCGCACGCCACGCAAATCATCGCGC
AAACGGGGCGCGTGCAGCCGGCCTCGGGCGGCGTCGGCACCACGGTCGACGTGCAGCACCTGTACTTCAACACGCCGGCG
CGCCGCAAATTCCTCAAGACCGAACAGACCGAACTGGGCCACTGCCTGGAGGTGATCCGCCGCACCGCACTGGCGCGCCC
GGACGTGGCCATCTCCGTGCATCACAACGGCAAGCCGCTGGAGCACTGGAACGCCGCCCAGGCCGACATGCGCACCGCCG
CCGTGCTGGGCACCGAGTTCGCCCGCGCCCGCCTGCCGTTCGAAGAGGCGGCCGGCGAGCTGCGCCTGTTCGGCTTTGCC
GGCCTGCCGACGGCCTCGCGCGGCCGGGCCGACCACCAGTTTTTCTACGTCAACGGTCGCTTCGTGCGCGACCGCCTGTT
GACCCACGCCGTGCGCAGCGCCTATGAAGACGTACTGCACGGCGACCGCTTCCCCGCCTACGTGCTGTGCCTGGAGCTGC
CGCCCGAGGCGGTGGACGTGAACGTGCATCCGTCCAAGATCGAGGTGCGCTTCCGCGACAGCCGCGCAGTGCACCAGTTC
GTCTACCACGCGGTGCAGCGCGCGCTGTCGCGCCACGCCGGCGAACAGGGCGACAGCCTGCGCACCGACATCGCCGACGC
GCCCGAGCAGCCCGGCGCCACGGCCACGCCCGCCGACAACACCACGCGCTGGGTCAACCAGATGGCCGCGCGGCAGACCT
CGCTCGGCATCGCCCAGCCGCGCGCGGAATACCTGGCGATGATGCGCGGCGGCAGCGCGCCGCAGCCGTCGAGCCGCCCG
GCATGGATGGCCGACGTGCCGAGCGCCGCCACCCTGTTCGATGGCGCGGCCTCCGCACCCGCCGACGCGGCCCCGGCTCA
GGCATCCGAGCCGGCAGCGGCGCCGCAAGCCGATGACAGCGACGACGCGCACCCGCTCGGCTTCGCCGTCGCCCAGCTGC
ACGGCATCTACGTGCTGGCGCAGAACGCGCGCGGCATGGTGCTGGTCGACATGCACGCCGCGCACGAGCGCATCCTGTAC
GAACAGCTGAAAACGGCGCTGGAAGCCAGGCGCATCGAAGTGCAGCCGCTGCTGATCCCGGTCACCTTTGCGGCCAGTCC
GGTGGAGATCGGCACGGCGGAGGAATTCGGCGACACGCTGGACCTGCTCGGCTTCGACATCAGCGCCGTCTCGCCGACCA
CGCTGGCGGTGCGCGCCGTGCCCACGCTGCTGCAGAAGGCCGATGCCCAGGCGCTCGCCCGCGACGTGCTGCGCGACCTG
CAAGCCTACGGCGGCTCGCGCGTGCTGGCCGAGCGCCAGAACGAGCTGCTCGCCACGCTGGCCTGCCATTCCGCCGTGCG
CGCCAACCGCCGGCTGAACCTGGACGAAATGAACGCCCTGCTGCGCCAGATGGAAGCCACCGAACGCGCCGACCAGTGCA
ACCACGGCCGGCCGACGTGGATCCAGCTGACGGTCGCCGATCTGGACCGGCTGTTCCTGCGCGGCCAGTGA

Upstream 100 bases:

>100_bases
GGGCCCGGCCGTCGACACGCGGACCGCGCAGTCGCCATGACGGGCCAGGGCGGGCACCGGTGCCCTGCGCCGCACCGGGG
GCGGCCTTTATAATGCCGCG

Downstream 100 bases:

>100_bases
CCGCACGATGACCGCCGCCCCGCACACCGCCCCGCGCGCCGTCTGCCTGCTCGGCCCGACCGCCTCCGGCAAGACCGCCG
CCGCGCTCGCGCTCGCCGAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MTAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVRRIAITDNGGGIPVDELPVAL
MRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTSRTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPA
RRKFLKTEQTELGHCLEVIRRTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFA
GLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDVNVHPSKIEVRFRDSRAVHQF
VYHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADNTTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRP
AWMADVPSAATLFDGAASAPADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILY
EQLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAVPTLLQKADAQALARDVLRDL
QAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNALLRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ

Sequences:

>Translated_636_residues
MTAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVRRIAITDNGGGIPVDELPVAL
MRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTSRTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPA
RRKFLKTEQTELGHCLEVIRRTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFA
GLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDVNVHPSKIEVRFRDSRAVHQF
VYHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADNTTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRP
AWMADVPSAATLFDGAASAPADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILY
EQLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAVPTLLQKADAQALARDVLRDL
QAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNALLRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ
>Mature_635_residues
TAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVRRIAITDNGGGIPVDELPVALM
RHATSKIGSLEELESVATLGFRGEALASIASVAELTLTSRTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPAR
RKFLKTEQTELGHCLEVIRRTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFAG
LPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDVNVHPSKIEVRFRDSRAVHQFV
YHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADNTTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRPA
WMADVPSAATLFDGAASAPADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILYE
QLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAVPTLLQKADAQALARDVLRDLQ
AYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNALLRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=335, Percent_Identity=34.3283582089552, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4505911, Length=330, Percent_Identity=31.8181818181818, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI189458898, Length=330, Percent_Identity=31.8181818181818, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI189458896, Length=314, Percent_Identity=31.8471337579618, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=28.6532951289398, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=28.6532951289398, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=29.045643153527, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI310128480, Length=297, Percent_Identity=26.5993265993266, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=24.4274809160305, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=24.4274809160305, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790612, Length=565, Percent_Identity=42.8318584070797, Blast_Score=354, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=380, Percent_Identity=25, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=318, Percent_Identity=33.9622641509434, Blast_Score=183, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=470, Percent_Identity=26.3829787234043, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323063, Length=146, Percent_Identity=29.4520547945205, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=34.5161290322581, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17136970, Length=356, Percent_Identity=26.123595505618, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_RALSO (Q8XWB1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520684.1
- ProteinModelPortal:   Q8XWB1
- SMR:   Q8XWB1
- GeneID:   1221410
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2563
- NMPDR:   fig|267608.1.peg.2563
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   RSOL267608:RSC2563-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 68733; Mature: 68601

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEE
RIAITDNGGGIPVDELPVALMRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTS
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPARRKFLKTEQTELGHCLEVIR
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHEEECCHHHHHHHHHHHHHHHHHHHHHH
RTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFA
HHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEE
GLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDV
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEE
NVHPSKIEVRFRDSRAVHQFVYHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADN
EECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCC
TTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRPAWMADVPSAATLFDGAASAP
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCC
ADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHHH
EQLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAV
HHHHHHHHHHCEEECEEEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCCCCCHHHHHHHH
PTLLQKADAQALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNAL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
TAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEE
RIAITDNGGGIPVDELPVALMRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTS
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPARRKFLKTEQTELGHCLEVIR
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHEEECCHHHHHHHHHHHHHHHHHHHHHH
RTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFA
HHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEE
GLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDV
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEE
NVHPSKIEVRFRDSRAVHQFVYHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADN
EECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCC
TTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRPAWMADVPSAATLFDGAASAP
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCC
ADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHHH
EQLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAV
HHHHHHHHHHCEEECEEEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCCCCCHHHHHHHH
PTLLQKADAQALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNAL
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852