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The map label for this gene is argG [H]

Identifier: 17547272

GI number: 17547272

Start: 2761604

End: 2762941

Strand: Direct

Name: argG [H]

Synonym: RSc2553

Alternate gene names: 17547272

Gene position: 2761604-2762941 (Clockwise)

Preceding gene: 17547271

Following gene: 17547274

Centisome position: 74.31

GC content: 64.57

Gene sequence:

>1338_bases
ATGGAAACCATCCTGCAACACGTTCCCGTCGGCCAGAAGGTCGGCATCGCCTTCTCCGGCGGCCTGGACACCAGCGCGGC
CCTGCGCTGGATGAAGAACAAGGGCGCCCTGCCCTATGCCTACACCGCCAATCTCGGCCAGCCCGACGAGGAAGACTACG
ATGCCATCCCCCGCAAGGCCCTGGAATACGGTGCAGAGAAGGCTCGCCTGATCGACTGCCGCCCGCAACTGGCCAATGAA
GGCATTGCCGCCATCCAGGCCGGCGCCTTCCACATCAGCACCGGCGGCATCACCTACTTCAACACCACGCCGTTGGGCCG
CGCCGTGACCGGCACCATGCTGGTGGCCGCCATGAAGGAAGACGACGTCCACATCTGGGGCGACGGCTCCACCTTCAAGG
GCAATGACATCGAGCGCTTCTACCGCTACGGCCTGCTGACCAACCCGGCCCTGAAGATCTACAAGCCGTGGCTTGACCAG
ACCTTCATCGACGAGCTGGGCGGCCGCGCCGAAATGTCGGCCTTCATGACGAAGGAAGGTTTCGGCTACAAGATGAGCGC
CGAAAAGGCCTACTCCACCGACTCCAACATGCTGGGCGCCACCCACGAGGCCAAGGACCTGGAGCATCTGAACAGCGGCA
TCCGCATCGTCAACCCGATCATGGGCGTGGCGTTCTGGAAGCCTGAAGTCGAAGTCAAGGCCGAAGAGGTTTCGATCACC
TTCGACGAAGGCCGCCCCGTGGCCGTCAACGGCCGCGAAATTGCCGACCCGGTGGAGATGTTCCTGGAGCTGAACCGCAT
CGGCGGCCGCCACGGCCTGGGCATGAGCGACCAGATCGAAAACCGCATCATCGAAGCCAAGAGCCGCGGCATCTACGAAG
CCCCGGGCATGGCGTTGCTGCACATCGCCTACGAGCGCCTGGTCACCGGCATCCACAACGAGGACACCATCGAGCAGTAC
CGCATCAATGGCCTGCGCCTAGGCCGCCTGCTGTACCAGGGCCGCTGGTTCGACCCGCAGGCCATCATGCTGCGCGAAAC
CGCCCAACGCTGGGTGGCCCGCGCCGTGACCGGTACCGTGACGCTGGAGCTGCGCCGCGGCAACGATTACTCCATCCTGA
ACACCGAGTCGCCCAACCTGACCTACGCGCCCGAGCGCCTGTCGATGGAAAAGGTCGAAGACGCACCGTTCAGCCCGGCC
GACCGCATCGGCCAGCTGACCATGCGCAACCTGGACCTGATGGACACCCGCGACAAGCTGGCCATCTACTCCAAGGCCGG
CCTGCTGTCCCTGGGCACCAGCAGCGCGCTGCCCCAGCTCGGCGGCGACAAGAAGTAA

Upstream 100 bases:

>100_bases
CCTCGAGCCCGCTCCGGGGCAGCGCAGCCATTCCGGGCTTCTTTAGCCTCTGGCGCAGGCCAGTCAAACGCCAGCCGCGA
TCATTTTGAAGAGACACTCC

Downstream 100 bases:

>100_bases
GCGGCTGCTCACGCTTCAAAACGAAAAAGGCCGCTCCGACATCAATCGGAGCGGCCTTTTTTTGTGGCTTCAGACTCGGT
TCGAGTCACTGCCAGGTCAC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKALEYGAEKARLIDCRPQLANE
GIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQ
TFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT
FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQY
RINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPA
DRIGQLTMRNLDLMDTRDKLAIYSKAGLLSLGTSSALPQLGGDKK

Sequences:

>Translated_445_residues
METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKALEYGAEKARLIDCRPQLANE
GIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQ
TFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT
FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQY
RINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPA
DRIGQLTMRNLDLMDTRDKLAIYSKAGLLSLGTSSALPQLGGDKK
>Mature_445_residues
METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKALEYGAEKARLIDCRPQLANE
GIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQ
TFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT
FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQY
RINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPA
DRIGQLTMRNLDLMDTRDKLAIYSKAGLLSLGTSSALPQLGGDKK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=411, Percent_Identity=30.1703163017032, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI16950633, Length=411, Percent_Identity=30.1703163017032, Blast_Score=149, Evalue=7e-36,
Organism=Escherichia coli, GI1789563, Length=440, Percent_Identity=77.9545454545455, Blast_Score=718, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324514, Length=416, Percent_Identity=28.3653846153846, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21358151, Length=392, Percent_Identity=30.8673469387755, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 49301; Mature: 49301

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKA
CCCHHHHCCCCCEECEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
LEYGAEKARLIDCRPQLANEGIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKE
HHCCCCCEEEEECCHHHHCCCCEEEECCEEEEECCCEEEEECCCCCHHHHHHHEEEEECC
DDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQTFIDELGGRAEMSAFMTKEG
CCEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
FGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT
CCEEECCCHHCCCCCCCCCCCCHHHHHHHHHCCCEEHHHHHHHEEECCCCEEEEEEEEEE
FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL
ECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
HIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTV
HHHHHHHHHCCCCCCHHHHHHHCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
TLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDLMDTRDKL
EEEEECCCCEEEEECCCCCCEECHHHCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCE
AIYSKAGLLSLGTSSALPQLGGDKK
EEEECCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKA
CCCHHHHCCCCCEECEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
LEYGAEKARLIDCRPQLANEGIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKE
HHCCCCCEEEEECCHHHHCCCCEEEECCEEEEECCCEEEEECCCCCHHHHHHHEEEEECC
DDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQTFIDELGGRAEMSAFMTKEG
CCEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
FGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT
CCEEECCCHHCCCCCCCCCCCCHHHHHHHHHCCCEEHHHHHHHEEECCCCEEEEEEEEEE
FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL
ECCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
HIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTV
HHHHHHHHHCCCCCCHHHHHHHCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
TLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDLMDTRDKL
EEEEECCCCEEEEECCCCCCEECHHHCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCE
AIYSKAGLLSLGTSSALPQLGGDKK
EEEECCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA