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The map label for this gene is rihA [H]

Identifier: 17547267

GI number: 17547267

Start: 2756991

End: 2758046

Strand: Reverse

Name: rihA [H]

Synonym: RSc2548

Alternate gene names: 17547267

Gene position: 2758046-2756991 (Counterclockwise)

Preceding gene: 17547268

Following gene: 17547259

Centisome position: 74.21

GC content: 69.22

Gene sequence:

>1056_bases
ATGGCTACGTTTCCGAATGTCCCCCGTCGCGCATTCCTGAACCTGGTCAGCCTGTTTGCCGGCGGCGCGCTGCTGCCGGC
AAGCTCGCAAGCCGTTGGCCTGAGCGCCCCCGCTCCCGCCTCCGTGATCATCGATGCCGATCCAGGACAGGACGACGCGA
TCGCGATCCTGTTCGCGCTCGGGGCGAGGGGGCGCCTCGACGTGCGTGCCCTGACCGTCGTGGCGGGCAATGTGCCGCTG
GGCCTGACCGAGCGCAATGCGCGCATCATTCGCGACTGGGCGGGCCGCACGCATGCGTTGCCGGTCTACGCCGGCTGCGC
GGGGCCGCTGACGCGCGAGCTGGTCACGGCTGCCCACGTGCATGGCAAGACCGGTCTTGAAGGTGTCGATCTGCCCGCGC
CGTTGGCACCGCTGGCGTCGCAGCACGCGGTGTCGTACCTGGTTGATACGCTCACGCAGGCGGCGCCGAACAGCGTGACG
CTGTGTGCGCTCGGACCACTGACCAACATCGCCAGCGCGCTGAGCGAGGCTCCGCAGATCCGCCCCGCGCTGCGCGAGAT
CGTGCTGATGGGCGGTGCGCATTTCGAGCGCGGCAACATCACGCCGGCCGCGGAGTTCAACATCTACGTCGACCCGCAGG
CCGCCGAGATCGTGTTCGGCAGCGGCGTGCCGATCGTCGTGCTGCCGCGCGACGTCGCCATGAAGGCGCAGATCACGCTG
GCGCGGGTTGCACCGTTCCGCGGGCTCGGCAACCGCTGCGGCGCGATCGTCGCCGACATCATGGCGGCCGAGATCGCGTA
CCAGAAGACGCGCCGCGGCGTCGAGCGGGCGCCGATGTACGATCCGACCGCGGTCGGTTATCTGTTCGACCCGTCGATGT
TCAACGGGCGCAAGGTGAACGTGGTGGTCGAAACCGCCGGCCAGTGGACGCTGGGCGAGACCGTCGTCGACTGGGAAGGC
CGCAGCGGCCGCGCACCGAACGCGATGTGGATCCACGACGTCGATGCGGACCGCTTCTATGCCGCGCTGCTCGACAGCGT
CGCGAAGCTGCCCTAA

Upstream 100 bases:

>100_bases
ATGCTGCGCAAGGACGTGACCGACACGCCGCTGGATTTCAACAACTTCCGCGATTGAGCCTCCAGCCGGTTCCGGGACGA
CAACGTTGCCCTTGAATGAC

Downstream 100 bases:

>100_bases
CGGCGCATACCGAGGTATTGACGGCCATCACACAAGAGGGCGCACTTCGTCATCGTGCCCGCCGGTTCAGGCAAACGCCC
CGCACGCGCGGGGCGTTTGC

Product: inosine-uridine preferring nucleoside hydrolase transmembrane protein

Products: D-ribose; purine

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MATFPNVPRRAFLNLVSLFAGGALLPASSQAVGLSAPAPASVIIDADPGQDDAIAILFALGARGRLDVRALTVVAGNVPL
GLTERNARIIRDWAGRTHALPVYAGCAGPLTRELVTAAHVHGKTGLEGVDLPAPLAPLASQHAVSYLVDTLTQAAPNSVT
LCALGPLTNIASALSEAPQIRPALREIVLMGGAHFERGNITPAAEFNIYVDPQAAEIVFGSGVPIVVLPRDVAMKAQITL
ARVAPFRGLGNRCGAIVADIMAAEIAYQKTRRGVERAPMYDPTAVGYLFDPSMFNGRKVNVVVETAGQWTLGETVVDWEG
RSGRAPNAMWIHDVDADRFYAALLDSVAKLP

Sequences:

>Translated_351_residues
MATFPNVPRRAFLNLVSLFAGGALLPASSQAVGLSAPAPASVIIDADPGQDDAIAILFALGARGRLDVRALTVVAGNVPL
GLTERNARIIRDWAGRTHALPVYAGCAGPLTRELVTAAHVHGKTGLEGVDLPAPLAPLASQHAVSYLVDTLTQAAPNSVT
LCALGPLTNIASALSEAPQIRPALREIVLMGGAHFERGNITPAAEFNIYVDPQAAEIVFGSGVPIVVLPRDVAMKAQITL
ARVAPFRGLGNRCGAIVADIMAAEIAYQKTRRGVERAPMYDPTAVGYLFDPSMFNGRKVNVVVETAGQWTLGETVVDWEG
RSGRAPNAMWIHDVDADRFYAALLDSVAKLP
>Mature_350_residues
ATFPNVPRRAFLNLVSLFAGGALLPASSQAVGLSAPAPASVIIDADPGQDDAIAILFALGARGRLDVRALTVVAGNVPLG
LTERNARIIRDWAGRTHALPVYAGCAGPLTRELVTAAHVHGKTGLEGVDLPAPLAPLASQHAVSYLVDTLTQAAPNSVTL
CALGPLTNIASALSEAPQIRPALREIVLMGGAHFERGNITPAAEFNIYVDPQAAEIVFGSGVPIVVLPRDVAMKAQITLA
RVAPFRGLGNRCGAIVADIMAAEIAYQKTRRGVERAPMYDPTAVGYLFDPSMFNGRKVNVVVETAGQWTLGETVVDWEGR
SGRAPNAMWIHDVDADRFYAALLDSVAKLP

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=305, Percent_Identity=43.2786885245902, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1788486, Length=307, Percent_Identity=37.4592833876222, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1786213, Length=299, Percent_Identity=38.1270903010033, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32565474, Length=192, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565698, Length=306, Percent_Identity=28.4313725490196, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320608, Length=265, Percent_Identity=28.3018867924528, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24583915, Length=292, Percent_Identity=29.4520547945205, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641837, Length=335, Percent_Identity=26.865671641791, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641839, Length=296, Percent_Identity=28.7162162162162, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: 3.2.2.1

Molecular weight: Translated: 36932; Mature: 36801

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01247 IUNH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATFPNVPRRAFLNLVSLFAGGALLPASSQAVGLSAPAPASVIIDADPGQDDAIAILFAL
CCCCCCCHHHHHHHHHHHHHCCEECCCCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEC
GARGRLDVRALTVVAGNVPLGLTERNARIIRDWAGRTHALPVYAGCAGPLTRELVTAAHV
CCCCCCEEEEEEEEECCCCCCEECCCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHH
HGKTGLEGVDLPAPLAPLASQHAVSYLVDTLTQAAPNSVTLCALGPLTNIASALSEAPQI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCH
RPALREIVLMGGAHFERGNITPAAEFNIYVDPQAAEIVFGSGVPIVVLPRDVAMKAQITL
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCEEEEECCCCCEEEECCCCCEEEEEEE
ARVAPFRGLGNRCGAIVADIMAAEIAYQKTRRGVERAPMYDPTAVGYLFDPSMFNGRKVN
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCEEEE
VVVETAGQWTLGETVVDWEGRSGRAPNAMWIHDVDADRFYAALLDSVAKLP
EEEEECCCEEECCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATFPNVPRRAFLNLVSLFAGGALLPASSQAVGLSAPAPASVIIDADPGQDDAIAILFAL
CCCCCCHHHHHHHHHHHHHCCEECCCCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEC
GARGRLDVRALTVVAGNVPLGLTERNARIIRDWAGRTHALPVYAGCAGPLTRELVTAAHV
CCCCCCEEEEEEEEECCCCCCEECCCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHH
HGKTGLEGVDLPAPLAPLASQHAVSYLVDTLTQAAPNSVTLCALGPLTNIASALSEAPQI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCH
RPALREIVLMGGAHFERGNITPAAEFNIYVDPQAAEIVFGSGVPIVVLPRDVAMKAQITL
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCEEEEECCCCCEEEECCCCCEEEEEEE
ARVAPFRGLGNRCGAIVADIMAAEIAYQKTRRGVERAPMYDPTAVGYLFDPSMFNGRKVN
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCEEEE
VVVETAGQWTLGETVVDWEGRSGRAPNAMWIHDVDADRFYAALLDSVAKLP
EEEEECCCEEECCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-D-ribosylpurine; H2O

Specific reaction: an N-D-ribosylpurine + H2O = D-ribose + a purine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA