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The map label for this gene is icd [H]

Identifier: 17547209

GI number: 17547209

Start: 2695967

End: 2697217

Strand: Reverse

Name: icd [H]

Synonym: RSc2490

Alternate gene names: 17547209

Gene position: 2697217-2695967 (Counterclockwise)

Preceding gene: 17547215

Following gene: 17547208

Centisome position: 72.58

GC content: 61.63

Gene sequence:

>1251_bases
ATGTACCAACACATCAAGGTCCCGGCCGGAGAGAAGATCACCGTCAACCAAGACTTCTCCCTGAACGTCCCCGATAACCC
CATCATTCCTTACATCGAGGGCGACGGCACCGGCTTCGATATCACCCCCGTGATGATCAAGGTGGTGGACGCGGCCGTGG
AGAAGGCCTATGCCGGCAAGCGCAAGATTTCCTGGATGGAAATCTACGCCGGCGAGAAGTCGACCAAGGTGTACGGCCCG
GACGTGTGGCTGCCGGAAGAAACCCTGCAGGTCCTCAAGGACTACGTGGTCTCGATCAAGGGCCCGCTGACGACGCCGGT
GGGCGGCGGCATCCGTTCGCTGAACGTGGCGCTGCGCCAGGAGCTGGACCTGTACGTCTGCCTGCGCCCGGTGCGCTACT
TCAAGGGCGTGCCCTCGCCGGTCAAGGAGCCGGAGAAGACCGACATGGTCATCTTCCGCGAGAACTCGGAAGACATCTAC
GCCGGCATCGAGTTCGAAGCCCAGAGCGACAAGGCCAAGAAGCTGATCAAGATCCTGCAGGACGAGTTCGGCGTTAAGAA
GATCCGCTTCCCGGAGACCTCGGGCATCGGCGTCAAGCCGGTCTCGAAGGAAGGCACTGAGCGCCTGGTGCGCAAGGCCA
TCCAGTACGCGATCGACAACGACAAGCCGTCGGTCACGATCGTGCACAAGGGCAATATCATGAAGTTCACGGAAGGCGGT
TTCCGTGACTGGGCCTACGCGCTGGCGCAAAAGGAATTCGGCGCCGAGCTGATCGATGGCGGTCCGTGGTGCAAGTTCAA
GAACCCGAAGACGGGCAAGGAAATCGTCGTCAAGGACGCGATTGCCGACGCCTTCCTGCAGCAGATCCTGCTGCGTCCGG
CCGAGTACTCGGTGGTGGCGACGCTGAACCTGAACGGCGACTACATCTCCGACGCGCTGGCCGCACAGGTCGGCGGCATC
GGCATCGCCCCGGGCGCGAACCTGAGCGACTCCGTCGCGATGTTCGAGGCCACCCACGGCACGGCTCCGAAGTACGCCGG
CAAGGACTACGTGAACCCGGGTTCGGAAATCCTGTCGGCCGAAATGATGCTGCGCCACATGGGCTGGACGGAAGCCGCTG
ACCTGATCATCTCGTCGATCGAGAAGTCGATCCTGTCGAAGAAGGTCACGTATGACTTCGCCCGCCTGCTGGAAGGCGCG
ACGCAGGTGTCGTGCTCGGGCTTTGGTCAGGTGATGATCGACAATATGTAA

Upstream 100 bases:

>100_bases
ATCGCCAGTTCATTGCAGCGCGCCAGCCGGCCAGCTCGGCGCGCTGTGCTGTCAAACCCCACCGTCCATCCGCGTATCAG
CGGTCTGCACTGGAGTCGTC

Downstream 100 bases:

>100_bases
GTCCGTATCAGCCAGTATCAGGCTGACGCACAGAACCCCGGTAGATCAACGGTCTGCCGGGGTTTTTTGTTTCAGGTGGT
ATCAGGCAGTATCATGGAAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYQHIKVPAGEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIVVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Sequences:

>Translated_416_residues
MYQHIKVPAGEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIVVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM
>Mature_416_residues
MYQHIKVPAGEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGKRKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIVVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=398, Percent_Identity=30.6532663316583, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=28.125, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=28.125, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4758582, Length=276, Percent_Identity=28.6231884057971, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI28178838, Length=276, Percent_Identity=28.6231884057971, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.5966850828729, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=74.8201438848921, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=27.0557029177719, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081683, Length=406, Percent_Identity=25.1231527093596, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986051, Length=374, Percent_Identity=31.5508021390374, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=29.8360655737705, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=29.2358803986711, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=364, Percent_Identity=23.9010989010989, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=28.9002557544757, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=370, Percent_Identity=27.2972972972973, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324291, Length=366, Percent_Identity=28.1420765027322, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=24.0997229916898, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24643268, Length=351, Percent_Identity=34.4729344729345, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24643270, Length=351, Percent_Identity=34.4729344729345, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=29.5629820051414, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI161078635, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078639, Length=278, Percent_Identity=28.0575539568345, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078633, Length=278, Percent_Identity=28.0575539568345, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24650122, Length=278, Percent_Identity=28.0575539568345, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078637, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20130355, Length=354, Percent_Identity=24.5762711864407, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362242, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648872, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45685; Mature: 45685

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGK
CCCEEECCCCCEEEECCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQ
CCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIYAGIEFEAQSDKAKKLIKILQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHH
DEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
HHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIVVKDAIADAFLQQILLRPAEYSVVA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC
>Mature Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPDNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYAGK
CCCEEECCCCCEEEECCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQ
CCCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIYAGIEFEAQSDKAKKLIKILQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHH
DEFGVKKIRFPETSGIGVKPVSKEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
HHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIVVKDAIADAFLQQILLRPAEYSVVA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]