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The map label for this gene is ilvR [H]

Identifier: 17547130

GI number: 17547130

Start: 2615716

End: 2616651

Strand: Reverse

Name: ilvR [H]

Synonym: RSc2411

Alternate gene names: 17547130

Gene position: 2616651-2615716 (Counterclockwise)

Preceding gene: 17547132

Following gene: 17547129

Centisome position: 70.41

GC content: 72.65

Gene sequence:

>936_bases
ATGGACCTGCGCCAGCTCCGCTACTTCGTGACCGTTGCCGAGGAACTGCACTTCGGCCGCGCCGCCGCGCGCCTGGCGAT
GACGCAGCCGCCGCTGTCGCAGCAGATCCGCGCGCTGGAGGAGGAGCTGGGCGTCGCGCTGTTCCACCGCACGCAGCGCT
CGGTGGCGCTGACGCCGGTGGGGGCACGCTGGCTGGTGGAGGTGCGGCGCGTCCTGGCGGAGGCGGGCGCGTTGCCGGCG
CTGGCGCAGCGGCTGGCGCGCGGCGAGGTGGGGTCGCTGTCGCTGGCCTTTGTCAGCACGGCCGACTACGGCATCCTGCC
CGCCATGCTGCGCCATTTCCGCGATGCCCGGCCCGACGTGCAGGTGCAATTGCGCGAAGCCACCAGCGACGTGCAGATCG
AGGCACTGCTGGCCGACGAGATCGACGCCGGCGTAGTGATCGCGCATCACATCGGCTCCGTGCCGGGCGAACTGGAATAC
CGGCCGCTGGCGCGCGAGGGGCTGGTGCTGGCCGTGCCCGCGGCGCGCGCGGCGCAATGGGGCGCGCGGCCCGGCCGGCC
GATCGCGCTGGCCGACGTGGCCGCCGAGCCGCTGATTATTTTCCCGCGCCGTTCCGCGCCGGCGCTGTACGACATCATTA
CCGGCTATCATGCCGCGCACGGCGGCGCCCAGGAGGCGTCCGCGCGCATCGCCCAGGAGGCGATCCAGATGCAGACCATC
GTCAGCCTCGTCTCCGCCGAGATGGGCGTGGCCCTGGTGCCCGCATCGCTGTGCAACCTGCAGCGGACCGGCGTGGTCTA
TCTCGAACTGGCCGAGCCGAGCCCGGTCATCGAGACCGGGCTGGTCTGGCGGCGCGACGCGGTATCGCCCGTGGTGCCGT
GGTTCGTGGCCAGCGCCGAGGCCGTGGCCCGCTTGCATGACAACCCCCAACCCTGA

Upstream 100 bases:

>100_bases
TTTTGGGAAAATCGCTGGCGCACAGCATGCCGCTGGACAAAAGTCGTGTCAAATATATTATTGAGCGATTATTGAGTCGA
AAAAAATATCAATAGAAACC

Downstream 100 bases:

>100_bases
GACCCCCGGATTCATGCTCATCCATCCGCAATTCGATCCCATCGCGCTGCATCTCGGGCCGCTCGCCATCCGTTGGTACG
GCCTGATGTACCTGGCCGCG

Product: transcription regulator protein

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MDLRQLRYFVTVAEELHFGRAAARLAMTQPPLSQQIRALEEELGVALFHRTQRSVALTPVGARWLVEVRRVLAEAGALPA
LAQRLARGEVGSLSLAFVSTADYGILPAMLRHFRDARPDVQVQLREATSDVQIEALLADEIDAGVVIAHHIGSVPGELEY
RPLAREGLVLAVPAARAAQWGARPGRPIALADVAAEPLIIFPRRSAPALYDIITGYHAAHGGAQEASARIAQEAIQMQTI
VSLVSAEMGVALVPASLCNLQRTGVVYLELAEPSPVIETGLVWRRDAVSPVVPWFVASAEAVARLHDNPQP

Sequences:

>Translated_311_residues
MDLRQLRYFVTVAEELHFGRAAARLAMTQPPLSQQIRALEEELGVALFHRTQRSVALTPVGARWLVEVRRVLAEAGALPA
LAQRLARGEVGSLSLAFVSTADYGILPAMLRHFRDARPDVQVQLREATSDVQIEALLADEIDAGVVIAHHIGSVPGELEY
RPLAREGLVLAVPAARAAQWGARPGRPIALADVAAEPLIIFPRRSAPALYDIITGYHAAHGGAQEASARIAQEAIQMQTI
VSLVSAEMGVALVPASLCNLQRTGVVYLELAEPSPVIETGLVWRRDAVSPVVPWFVASAEAVARLHDNPQP
>Mature_311_residues
MDLRQLRYFVTVAEELHFGRAAARLAMTQPPLSQQIRALEEELGVALFHRTQRSVALTPVGARWLVEVRRVLAEAGALPA
LAQRLARGEVGSLSLAFVSTADYGILPAMLRHFRDARPDVQVQLREATSDVQIEALLADEIDAGVVIAHHIGSVPGELEY
RPLAREGLVLAVPAARAAQWGARPGRPIALADVAAEPLIIFPRRSAPALYDIITGYHAAHGGAQEASARIAQEAIQMQTI
VSLVSAEMGVALVPASLCNLQRTGVVYLELAEPSPVIETGLVWRRDAVSPVVPWFVASAEAVARLHDNPQP

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=38.8888888888889, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI2367136, Length=291, Percent_Identity=32.3024054982818, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788887, Length=299, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790399, Length=307, Percent_Identity=32.2475570032573, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693105, Length=304, Percent_Identity=25.9868421052632, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI157672245, Length=305, Percent_Identity=30.8196721311475, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082132, Length=304, Percent_Identity=27.6315789473684, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790208, Length=179, Percent_Identity=34.0782122905028, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=37.2262773722628, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788748, Length=261, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081904, Length=213, Percent_Identity=30.0469483568075, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788297, Length=265, Percent_Identity=26.4150943396226, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789173, Length=155, Percent_Identity=33.5483870967742, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=28.135593220339, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787530, Length=130, Percent_Identity=31.5384615384615, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786713, Length=88, Percent_Identity=42.0454545454545, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787601, Length=301, Percent_Identity=24.2524916943522, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33538; Mature: 33538

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRQLRYFVTVAEELHFGRAAARLAMTQPPLSQQIRALEEELGVALFHRTQRSVALTPV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GARWLVEVRRVLAEAGALPALAQRLARGEVGSLSLAFVSTADYGILPAMLRHFRDARPDV
CHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
QVQLREATSDVQIEALLADEIDAGVVIAHHIGSVPGELEYRPLAREGLVLAVPAARAAQW
EEEEECCCCCEEEEEEECCCCCCCEEEEHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHC
GARPGRPIALADVAAEPLIIFPRRSAPALYDIITGYHAAHGGAQEASARIAQEAIQMQTI
CCCCCCCEEEHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VSLVSAEMGVALVPASLCNLQRTGVVYLELAEPSPVIETGLVWRRDAVSPVVPWFVASAE
HHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCEECCCCCCHHHHHHHHHHH
AVARLHDNPQP
HHHHHCCCCCC
>Mature Secondary Structure
MDLRQLRYFVTVAEELHFGRAAARLAMTQPPLSQQIRALEEELGVALFHRTQRSVALTPV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GARWLVEVRRVLAEAGALPALAQRLARGEVGSLSLAFVSTADYGILPAMLRHFRDARPDV
CHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
QVQLREATSDVQIEALLADEIDAGVVIAHHIGSVPGELEYRPLAREGLVLAVPAARAAQW
EEEEECCCCCEEEEEEECCCCCCCEEEEHHHCCCCCCCCCCCCCCCCEEEEECCHHHHHC
GARPGRPIALADVAAEPLIIFPRRSAPALYDIITGYHAAHGGAQEASARIAQEAIQMQTI
CCCCCCCEEEHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VSLVSAEMGVALVPASLCNLQRTGVVYLELAEPSPVIETGLVWRRDAVSPVVPWFVASAE
HHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCEECCCCCCHHHHHHHHHHH
AVARLHDNPQP
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]