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The map label for this gene is cobQ [H]

Identifier: 17547109

GI number: 17547109

Start: 2597443

End: 2598930

Strand: Reverse

Name: cobQ [H]

Synonym: RSc2390

Alternate gene names: 17547109

Gene position: 2598930-2597443 (Counterclockwise)

Preceding gene: 17547114

Following gene: 17547108

Centisome position: 69.93

GC content: 72.98

Gene sequence:

>1488_bases
ATGTCGACCTCGCCGTTTTCCGGGCCGCCGCGCGGCACGCTGATGATCCAGGGCACCACTTCCGATGCCGGCAAGAGCAC
GCTGGTGGCGGGCCTGTGCCGCATCGCGCATCGCGCGGGCGTGCGCGTGGCGCCGTTCAAGCCGCAGAACATGGCGCTCA
ACAGCGCGGTGACGGCCGACGGCGGCGAGATCGGGCGGGCGCAGGCCCTGCAGGCGCAGGCCGCCGGCCTGGCGCCCACG
GTGGACATGAATCCGGTGCTGCTCAAGCCCAACAGCGACACCGGCGCGCAGGTCATCATCCACGGCCGGCCGCGCGGCGA
TCTGAATGCGCGCGCCTATCACGACTACAAGCCGACCGCGATGGCCGCCGTGCTCGCCTCGCACGGCCGCCTGCGCGCGC
AGTACGACCTGGTGCTGGTCGAAGGCGCCGGCAGCCCCGCCGAGGTCAACCTGCGCGCGCGCGATATCGCCAACATGGGT
TTTGCCGAGGCGGTCGACTGCCCGGTCGTGCTGGTCGCCGACATCGACCGCGGCGGCGTGTTCGCGCACCTGGTCGGCAC
GCTGGCCTGCCTGTCGGAAAGCGAGCGAGCGCGCGTGACGGGCTTCGTCATCAACCGCTTTCGCGGCGATCTCTCTCTGC
TGACGCCCGGCCTCGACTGGCTGACGGCGCAGACCGGCAAGCCGGTGTTCGGCGTGCTGCCGTATCTGCAGGGGCTGCAC
CTGGATGCGGAGGATGCCGTGCAGACGGCGCAATCCGCCGCCTCGGGCGAGGTGCTGCGCGTCGTCATCCCGGTGCTGCC
GCGCATCTCCAACCACACCGATTTCGATGCGCTGCGCGCGCACCCGCAGGTCGACGTGCGGATGGTCGGGCCGGGCCGGC
CGATCCCGCCGGCGGACCTGGTCATCCTGCCCGGCAGCAAGAGTGTGCAGGCCGATCTCGCCTGGCTGCGCGCGCACGGC
TGGGATGCCGCCATCGCGCGCCACCTGCGCTACGGCGGCAAGCTGATCGGCATCTGCGGCGGCATGCAGATGCTGGGGCG
CCGGCTGCGCGATCCGCTCGGGCTGGAAGGGCGGCCGGGGAGCCTCGACGGCCTGGGCTATCTCGATTTCGAGACGACGC
TGGCACCCGCCAAGCAGCTGCGGCAGGTGCGCGGCACGCTGGCGGATGGCGGCGCGGCGCTCGCCGGCTACGAAATCCAC
ATGGGCGTGACCGAGGGCCCGGCCCTGGCGCGGCCCGCCGTCCGGCTCGACGATGGCCGCACCGATGGCGCGGTGTCCGC
CGACGGGCAGATCCTCGCCACCTACCTGCACGGCCTGTTCGACGCGCCCGAGGCGTGCCGCGCGCTGCTGGCCTGGGCGG
GCGTGCGCGAGGCCCGTGCGCAGGACTACGCCGCGCTGCGCGAGGCCTCGCTCGAGCGCCTGGCCGATACGCTGCGGGCG
CATCTCGACCTGCCGGCCCTGTTTGCCTCGCTGGCGGTTCGCGGCTGA

Upstream 100 bases:

>100_bases
GGCTCTTGCCCGAGCGGGCGCCACCGAGAACGAGCGTGAGACGGCGTGACATCCCAGCATTCTAGCGAGGGCGGCCACCG
GCGGGTGCGATAATCCGCGC

Downstream 100 bases:

>100_bases
GCCATAATCAGCCCATGGACCGATCTGCCGGGTGATGTTGCCGGCACACGCTGGGCGCGCGAGGAGGCACACATGCCGGT
GGCCGTGGTAGCGAATCCGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSTSPFSGPPRGTLMIQGTTSDAGKSTLVAGLCRIAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGLAPT
VDMNPVLLKPNSDTGAQVIIHGRPRGDLNARAYHDYKPTAMAAVLASHGRLRAQYDLVLVEGAGSPAEVNLRARDIANMG
FAEAVDCPVVLVADIDRGGVFAHLVGTLACLSESERARVTGFVINRFRGDLSLLTPGLDWLTAQTGKPVFGVLPYLQGLH
LDAEDAVQTAQSAASGEVLRVVIPVLPRISNHTDFDALRAHPQVDVRMVGPGRPIPPADLVILPGSKSVQADLAWLRAHG
WDAAIARHLRYGGKLIGICGGMQMLGRRLRDPLGLEGRPGSLDGLGYLDFETTLAPAKQLRQVRGTLADGGAALAGYEIH
MGVTEGPALARPAVRLDDGRTDGAVSADGQILATYLHGLFDAPEACRALLAWAGVREARAQDYAALREASLERLADTLRA
HLDLPALFASLAVRG

Sequences:

>Translated_495_residues
MSTSPFSGPPRGTLMIQGTTSDAGKSTLVAGLCRIAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGLAPT
VDMNPVLLKPNSDTGAQVIIHGRPRGDLNARAYHDYKPTAMAAVLASHGRLRAQYDLVLVEGAGSPAEVNLRARDIANMG
FAEAVDCPVVLVADIDRGGVFAHLVGTLACLSESERARVTGFVINRFRGDLSLLTPGLDWLTAQTGKPVFGVLPYLQGLH
LDAEDAVQTAQSAASGEVLRVVIPVLPRISNHTDFDALRAHPQVDVRMVGPGRPIPPADLVILPGSKSVQADLAWLRAHG
WDAAIARHLRYGGKLIGICGGMQMLGRRLRDPLGLEGRPGSLDGLGYLDFETTLAPAKQLRQVRGTLADGGAALAGYEIH
MGVTEGPALARPAVRLDDGRTDGAVSADGQILATYLHGLFDAPEACRALLAWAGVREARAQDYAALREASLERLADTLRA
HLDLPALFASLAVRG
>Mature_494_residues
STSPFSGPPRGTLMIQGTTSDAGKSTLVAGLCRIAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGLAPTV
DMNPVLLKPNSDTGAQVIIHGRPRGDLNARAYHDYKPTAMAAVLASHGRLRAQYDLVLVEGAGSPAEVNLRARDIANMGF
AEAVDCPVVLVADIDRGGVFAHLVGTLACLSESERARVTGFVINRFRGDLSLLTPGLDWLTAQTGKPVFGVLPYLQGLHL
DAEDAVQTAQSAASGEVLRVVIPVLPRISNHTDFDALRAHPQVDVRMVGPGRPIPPADLVILPGSKSVQADLAWLRAHGW
DAAIARHLRYGGKLIGICGGMQMLGRRLRDPLGLEGRPGSLDGLGYLDFETTLAPAKQLRQVRGTLADGGAALAGYEIHM
GVTEGPALARPAVRLDDGRTDGAVSADGQILATYLHGLFDAPEACRALLAWAGVREARAQDYAALREASLERLADTLRAH
LDLPALFASLAVRG

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 52103; Mature: 51972

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPFSGPPRGTLMIQGTTSDAGKSTLVAGLCRIAHRAGVRVAPFKPQNMALNSAVTAD
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEECC
GGEIGRAQALQAQAAGLAPTVDMNPVLLKPNSDTGAQVIIHGRPRGDLNARAYHDYKPTA
CCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCEECCCCHHH
MAAVLASHGRLRAQYDLVLVEGAGSPAEVNLRARDIANMGFAEAVDCPVVLVADIDRGGV
HHHHHHHCCCEEEEEEEEEEECCCCCCEEEEEHHHHHCCCCHHHCCCCEEEEEECCCCCH
FAHLVGTLACLSESERARVTGFVINRFRGDLSLLTPGLDWLTAQTGKPVFGVLPYLQGLH
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCHHEECCCCCCHHHHHHHHHCCC
LDAEDAVQTAQSAASGEVLRVVIPVLPRISNHTDFDALRAHPQVDVRMVGPGRPIPPADL
CCHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCE
VILPGSKSVQADLAWLRAHGWDAAIARHLRYGGKLIGICGGMQMLGRRLRDPLGLEGRPG
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
SLDGLGYLDFETTLAPAKQLRQVRGTLADGGAALAGYEIHMGVTEGPALARPAVRLDDGR
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEECCCC
TDGAVSADGQILATYLHGLFDAPEACRALLAWAGVREARAQDYAALREASLERLADTLRA
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLDLPALFASLAVRG
HCCHHHHHHHHHCCC
>Mature Secondary Structure 
STSPFSGPPRGTLMIQGTTSDAGKSTLVAGLCRIAHRAGVRVAPFKPQNMALNSAVTAD
CCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEECC
GGEIGRAQALQAQAAGLAPTVDMNPVLLKPNSDTGAQVIIHGRPRGDLNARAYHDYKPTA
CCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCEECCCCHHH
MAAVLASHGRLRAQYDLVLVEGAGSPAEVNLRARDIANMGFAEAVDCPVVLVADIDRGGV
HHHHHHHCCCEEEEEEEEEEECCCCCCEEEEEHHHHHCCCCHHHCCCCEEEEEECCCCCH
FAHLVGTLACLSESERARVTGFVINRFRGDLSLLTPGLDWLTAQTGKPVFGVLPYLQGLH
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCHHEECCCCCCHHHHHHHHHCCC
LDAEDAVQTAQSAASGEVLRVVIPVLPRISNHTDFDALRAHPQVDVRMVGPGRPIPPADL
CCHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCE
VILPGSKSVQADLAWLRAHGWDAAIARHLRYGGKLIGICGGMQMLGRRLRDPLGLEGRPG
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCCCCC
SLDGLGYLDFETTLAPAKQLRQVRGTLADGGAALAGYEIHMGVTEGPALARPAVRLDDGR
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCEEECCCC
TDGAVSADGQILATYLHGLFDAPEACRALLAWAGVREARAQDYAALREASLERLADTLRA
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLDLPALFASLAVRG
HCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]