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The map label for this gene is ytfL [H]

Identifier: 17546996

GI number: 17546996

Start: 2473127

End: 2474452

Strand: Direct

Name: ytfL [H]

Synonym: RSc2277

Alternate gene names: 17546996

Gene position: 2473127-2474452 (Clockwise)

Preceding gene: 17546983

Following gene: 17546999

Centisome position: 66.55

GC content: 66.97

Gene sequence:

>1326_bases
ATGTACGTGCTCGTTCTGGTCACGCTGATCCTGGTCAGCGCCTTCTTCTCCGCCGCGGAAATCGCCCTGACCGCCTCGCG
CCGCACCCGCCTGCAGACGCTTGCCGACGACGGCGACAGCCGCGCCCCGCGAATCCTGCAGCTCAAGGACACGCCGGGCA
ACTTCTTCACGGTCGTGCAGATCGGCGTGAACGCGGTCGCCATTCTGGCCGGCATCATCGGCGAGCGCCAGATCTCGGAC
ACGCTGGCCGGGTGGCTGGCCGACTGGCTGCCGCAGGCGCGCGCCGACCGCGTCGCCAACCTGGCCGGCTTCGTCATCGT
GACGGGGCTGTTCATCCTGTTTGCCGACCTGCTGCCCAAGCGCCTGGCGGTGCTCTACCCGGAGCGCTTCGCGCTGGCCA
TCATCGGGCCGATGCAGGGCTGCCTGCGGGTGCTGCGCCCGGTGGTCTGGGTGTTCAACGGGGCGGCCGACCTGATCCTG
AAGCTGCTGGGCGTGCCGACGCAGCGTGTCGAGCAGATCACCACCGAGGACATCGCCGCCATGGTGGGCGCCGGCGCCGA
GGCCGGCGTGCTGCGCAAGCATGAGCTGGCGGTGATCGAGAACGTGTTCGAGCTGGAGTCGCGCACCGTCACCTCCGTGA
TGACCGTGCGCGACGACATCGTCTACTTCACCCTCGATGAGCCGCTCGAATCGATCAAGCGCAAGATCGTCGGCCAACCG
CACGCCGAATACCTCGTCTGCCGCGACGACATCGACTCCGTGCTCGGCTTCATCGCCTCCAAGGACATCCTGCAGCAGAT
CCTGTCGGAGGAGTCTTCCGCCGTGATCCGCAATGTCGGCAAGCACTACAACAAGAATCTGCTGGTGCTGCCCGACACGC
TCAACCTGTCGCAGGCGCTCGCGCGCTTTCGCGAGATGCACGAGCGCTTCGGCGCGGTGGTCAACGAATACGGGCTGGTG
GTGGGCGTGGCGACGCTCGACGACATCGTCGGCGCGGTGATGGGCGACATCCTGTACCTGGGCGAGGACGAACAGATCGT
GCGCCGCGACGACGGCTCCTGCCTGGTCGACGGCATCACCCCGATCGCAGACGTCAAGCGCGCCTTCGACCTGGACGACC
TGCCCGGCGAACACTACGTGGAAACCATCGCCGGACTGGTCATCTACGCGCTCAAGCGCATCCCCAAGAAGAGCGAGAGC
GTCGACATCGGCCCGCTGCACATCGAGGTGCTCGACATGGACAGCCACCGCATCGATCAGTTGCTGGTGTCGCGGCGCAC
CGACGGGCCCGCCACATCGACACCCGCCACGCCGGCCGCATCCTGA

Upstream 100 bases:

>100_bases
GCGGCGGTTTGACAAAGCGATCGAGGCTCCACCATGATGGACCGGCGCCCGCCCGCGGGCAGTCGCCACCACCCGGCTTG
CCGGCCCTGACGGAAACACT

Downstream 100 bases:

>100_bases
GCGGCGAACATGCCGTTGAGCGCCGCGGGGAAGCCGGCATAGAGCGCCACGGTAATCTCCTCGCGGGTCAGCCCCACGTT
CAGTCCGGCCTCGATATGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MYVLVLVTLILVSAFFSAAEIALTASRRTRLQTLADDGDSRAPRILQLKDTPGNFFTVVQIGVNAVAILAGIIGERQISD
TLAGWLADWLPQARADRVANLAGFVIVTGLFILFADLLPKRLAVLYPERFALAIIGPMQGCLRVLRPVVWVFNGAADLIL
KLLGVPTQRVEQITTEDIAAMVGAGAEAGVLRKHELAVIENVFELESRTVTSVMTVRDDIVYFTLDEPLESIKRKIVGQP
HAEYLVCRDDIDSVLGFIASKDILQQILSEESSAVIRNVGKHYNKNLLVLPDTLNLSQALARFREMHERFGAVVNEYGLV
VGVATLDDIVGAVMGDILYLGEDEQIVRRDDGSCLVDGITPIADVKRAFDLDDLPGEHYVETIAGLVIYALKRIPKKSES
VDIGPLHIEVLDMDSHRIDQLLVSRRTDGPATSTPATPAAS

Sequences:

>Translated_441_residues
MYVLVLVTLILVSAFFSAAEIALTASRRTRLQTLADDGDSRAPRILQLKDTPGNFFTVVQIGVNAVAILAGIIGERQISD
TLAGWLADWLPQARADRVANLAGFVIVTGLFILFADLLPKRLAVLYPERFALAIIGPMQGCLRVLRPVVWVFNGAADLIL
KLLGVPTQRVEQITTEDIAAMVGAGAEAGVLRKHELAVIENVFELESRTVTSVMTVRDDIVYFTLDEPLESIKRKIVGQP
HAEYLVCRDDIDSVLGFIASKDILQQILSEESSAVIRNVGKHYNKNLLVLPDTLNLSQALARFREMHERFGAVVNEYGLV
VGVATLDDIVGAVMGDILYLGEDEQIVRRDDGSCLVDGITPIADVKRAFDLDDLPGEHYVETIAGLVIYALKRIPKKSES
VDIGPLHIEVLDMDSHRIDQLLVSRRTDGPATSTPATPAAS
>Mature_441_residues
MYVLVLVTLILVSAFFSAAEIALTASRRTRLQTLADDGDSRAPRILQLKDTPGNFFTVVQIGVNAVAILAGIIGERQISD
TLAGWLADWLPQARADRVANLAGFVIVTGLFILFADLLPKRLAVLYPERFALAIIGPMQGCLRVLRPVVWVFNGAADLIL
KLLGVPTQRVEQITTEDIAAMVGAGAEAGVLRKHELAVIENVFELESRTVTSVMTVRDDIVYFTLDEPLESIKRKIVGQP
HAEYLVCRDDIDSVLGFIASKDILQQILSEESSAVIRNVGKHYNKNLLVLPDTLNLSQALARFREMHERFGAVVNEYGLV
VGVATLDDIVGAVMGDILYLGEDEQIVRRDDGSCLVDGITPIADVKRAFDLDDLPGEHYVETIAGLVIYALKRIPKKSES
VDIGPLHIEVLDMDSHRIDQLLVSRRTDGPATSTPATPAAS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=384, Percent_Identity=25.2604166666667, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1790664, Length=439, Percent_Identity=47.6082004555809, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI145693175, Length=422, Percent_Identity=27.2511848341232, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87082033, Length=259, Percent_Identity=32.046332046332, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1788119, Length=264, Percent_Identity=29.1666666666667, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786879, Length=277, Percent_Identity=23.826714801444, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48168; Mature: 48168

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVLVLVTLILVSAFFSAAEIALTASRRTRLQTLADDGDSRAPRILQLKDTPGNFFTVVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
IGVNAVAILAGIIGERQISDTLAGWLADWLPQARADRVANLAGFVIVTGLFILFADLLPK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAVLYPERFALAIIGPMQGCLRVLRPVVWVFNGAADLILKLLGVPTQRVEQITTEDIAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
MVGAGAEAGVLRKHELAVIENVFELESRTVTSVMTVRDDIVYFTLDEPLESIKRKIVGQP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHHHCCCC
HAEYLVCRDDIDSVLGFIASKDILQQILSEESSAVIRNVGKHYNKNLLVLPDTLNLSQAL
CCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHH
ARFREMHERFGAVVNEYGLVVGVATLDDIVGAVMGDILYLGEDEQIVRRDDGSCLVDGIT
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHCCCCCCEEECCCC
PIADVKRAFDLDDLPGEHYVETIAGLVIYALKRIPKKSESVDIGPLHIEVLDMDSHRIDQ
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHH
LLVSRRTDGPATSTPATPAAS
HHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYVLVLVTLILVSAFFSAAEIALTASRRTRLQTLADDGDSRAPRILQLKDTPGNFFTVVQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
IGVNAVAILAGIIGERQISDTLAGWLADWLPQARADRVANLAGFVIVTGLFILFADLLPK
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAVLYPERFALAIIGPMQGCLRVLRPVVWVFNGAADLILKLLGVPTQRVEQITTEDIAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
MVGAGAEAGVLRKHELAVIENVFELESRTVTSVMTVRDDIVYFTLDEPLESIKRKIVGQP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHHHCCCC
HAEYLVCRDDIDSVLGFIASKDILQQILSEESSAVIRNVGKHYNKNLLVLPDTLNLSQAL
CCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHH
ARFREMHERFGAVVNEYGLVVGVATLDDIVGAVMGDILYLGEDEQIVRRDDGSCLVDGIT
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEECCCCHHHCCCCCCEEECCCC
PIADVKRAFDLDDLPGEHYVETIAGLVIYALKRIPKKSESVDIGPLHIEVLDMDSHRIDQ
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHH
LLVSRRTDGPATSTPATPAAS
HHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]