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The map label for this gene is pcp1

Identifier: 17546884

GI number: 17546884

Start: 2348446

End: 2349093

Strand: Reverse

Name: pcp1

Synonym: RSc2165

Alternate gene names: 17546884

Gene position: 2349093-2348446 (Counterclockwise)

Preceding gene: 17546885

Following gene: 17546881

Centisome position: 63.21

GC content: 68.98

Gene sequence:

>648_bases
ATGCCCACCGTCCTCGTCACCGGTTTCGATCCGTTCGAAAACGAGCCCGTCAACCCATCGTGGGAAGCCGTGCGCACGCT
CGACGGCCAGGGCATCGCCGGCGCCGACATCGTCACGCGCCAGTTGCCGACGGTGTTCGGCGAATCGATCCGGGTGCTCG
ACAGGCTGCTGATGAGCCTGCGCCCGGACGTGGTGATCGCCGTGGGCCAGGCCGGCGGGCGCGCCGAGATGGCCATCGAG
CGCGTCGCCATCAACGTGGACGATGCGCGCATCGCCGACAACGCCGGCCGGCAGCCGATCGATACCGCCATTGTCGCGGG
CGGGCCGGCGGCGTACTTCTCGACGCTGCCGATCAAGGCCATCGTGCACGAACTGCGCGCCGCCGGCGTGCCCGCCTCGG
TGTCGCAGACGGCGGGGACGTTCGTCTGCAACCATGTCTTCTATGGGCTGATGCACGCGATTGCCCACCACGGGCTGCAC
GCGCGCGGCGGCTTCATCCATATTCCCTATCTGCCGGCGCAGGCGGCCGGGCATCCCGGGCAGCCGAGCATGGCGCACGA
CACCGTCGTCGCCGGACTGCGCATTGCGATCGAGACAACGCTGCGCAGGCAGGAAGACATCCGGGAAGCGGGCGGTCAGT
TGCACTGA

Upstream 100 bases:

>100_bases
CGCAAGCTCAACTGACCGGGCAGCACGCAAGGCGCCCGGGCATGGTGCCGCCCGGGCGGCTATCATCATTGGCGATCGGG
TACCGTCGCAGGAGACCGTC

Downstream 100 bases:

>100_bases
GCCCGGGACGATCGTGCCCGCGACTCAGGGCGCGGGCGACCAGTGCGGATCGTTCAACTGCTTTTCCAGCAGGCGGATCT
GCTGCTGCAGCGAGTCGATC

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 1; Pyroglutamyl-peptidase I 1; PGP-I 1; Pyrase 1

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MPTVLVTGFDPFENEPVNPSWEAVRTLDGQGIAGADIVTRQLPTVFGESIRVLDRLLMSLRPDVVIAVGQAGGRAEMAIE
RVAINVDDARIADNAGRQPIDTAIVAGGPAAYFSTLPIKAIVHELRAAGVPASVSQTAGTFVCNHVFYGLMHAIAHHGLH
ARGGFIHIPYLPAQAAGHPGQPSMAHDTVVAGLRIAIETTLRRQEDIREAGGQLH

Sequences:

>Translated_215_residues
MPTVLVTGFDPFENEPVNPSWEAVRTLDGQGIAGADIVTRQLPTVFGESIRVLDRLLMSLRPDVVIAVGQAGGRAEMAIE
RVAINVDDARIADNAGRQPIDTAIVAGGPAAYFSTLPIKAIVHELRAAGVPASVSQTAGTFVCNHVFYGLMHAIAHHGLH
ARGGFIHIPYLPAQAAGHPGQPSMAHDTVVAGLRIAIETTLRRQEDIREAGGQLH
>Mature_214_residues
PTVLVTGFDPFENEPVNPSWEAVRTLDGQGIAGADIVTRQLPTVFGESIRVLDRLLMSLRPDVVIAVGQAGGRAEMAIER
VAINVDDARIADNAGRQPIDTAIVAGGPAAYFSTLPIKAIVHELRAAGVPASVSQTAGTFVCNHVFYGLMHAIAHHGLHA
RGGFIHIPYLPAQAAGHPGQPSMAHDTVVAGLRIAIETTLRRQEDIREAGGQLH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

Organism=Homo sapiens, GI8923198, Length=201, Percent_Identity=28.8557213930348, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP1_RALSO (Q8XXE9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520286.1
- ProteinModelPortal:   Q8XXE9
- SMR:   Q8XXE9
- MEROPS:   C15.001
- GeneID:   1221009
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2165
- NMPDR:   fig|267608.1.peg.2165
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   RSOL267608:RSC2165-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22780; Mature: 22649

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 167-167

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVLVTGFDPFENEPVNPSWEAVRTLDGQGIAGADIVTRQLPTVFGESIRVLDRLLMSL
CCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVVIAVGQAGGRAEMAIERVAINVDDARIADNAGRQPIDTAIVAGGPAAYFSTLPIKA
CCCEEEEECCCCCHHHHHHHHHEECCCCHHHCCCCCCCCCCCEEECCCCHHHHHHCCHHH
IVHELRAAGVPASVSQTAGTFVCNHVFYGLMHAIAHHGLHARGGFIHIPYLPAQAAGHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCC
QPSMAHDTVVAGLRIAIETTLRRQEDIREAGGQLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PTVLVTGFDPFENEPVNPSWEAVRTLDGQGIAGADIVTRQLPTVFGESIRVLDRLLMSL
CEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RPDVVIAVGQAGGRAEMAIERVAINVDDARIADNAGRQPIDTAIVAGGPAAYFSTLPIKA
CCCEEEEECCCCCHHHHHHHHHEECCCCHHHCCCCCCCCCCCEEECCCCHHHHHHCCHHH
IVHELRAAGVPASVSQTAGTFVCNHVFYGLMHAIAHHGLHARGGFIHIPYLPAQAAGHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCC
QPSMAHDTVVAGLRIAIETTLRRQEDIREAGGQLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852