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The map label for this gene is emrK [H]

Identifier: 17546572

GI number: 17546572

Start: 2035646

End: 2036803

Strand: Reverse

Name: emrK [H]

Synonym: RSc1853

Alternate gene names: 17546572

Gene position: 2036803-2035646 (Counterclockwise)

Preceding gene: 17546573

Following gene: 17546571

Centisome position: 54.81

GC content: 69.17

Gene sequence:

>1158_bases
ATGTCCGACAACAACCAAACGGCCGACGCCACTGCGGCTGCGCCTTCCAAGCAACGCCGCGCCCGGCTCTTTCTGATCCT
GGCTGCTGTGGTGGCCGCAGGCGCCATCGGCGGCACGGCCTACTGGCAGCTCTATGCCTCGCGCTTCGTCTCCACCGACA
ACGCCTATGCCGCCGTCGAAATCGCCCAGGTGACGCCCGCCATCGATGGCACGATCGCCGAAGTGCGTGTCAGCGACACC
CAGGCGGTCAAGAAGGGCGACGTGCTGGTGGTGATCGACCCGACCGACGCCAAGCTGGCGCTGGAACAGGCCGAGGCCCA
ACTGGGCAGCGCCGTGCGCCGGGTGCGCGGCTACGTCGCCAACGACAGCAGCCTGGGTGCGCAGATCATCGCCAGAGAGG
CGGACGAGAAGCGCGCCGCGGCCGACCTGTTCTCGGCGCAAGCCGACTTCGAGCGGGCCAAGATCGACCTGCGCCGCCGT
GAGGCGCTGGTAGCCTCCGGCTCGGTCTCGGGCGAGGAACTGACCAAAGCCCGCAACGCCCACGCCACGGCGGATGCGGC
GCGGGCCGCGCCCGCATCCGCCCAGGCGCGGGCAAATCGCAATGCCGCCGTGGGTTCGCGGCAGGCCAACGCGGTGCTGA
TCGCCAACGCCACGGAAGACACCAACCCCGAAGTCGCCCTGGCCCGCGCCAAGCGGGATCAGGCCGCGGTCGATCTGGGC
CGCACCGTCATTCGCGCGCCGGTGGACGGCGTGGTCGCCAAGCGCCAGGTGCAGCTCGGCCAGCGGGTGAAGTCCGGCAC
GGCGCTGCTGTCCATCGTGCCGGTGCAGGACATGCACGTGGATGCCAACTTCAAGGAAGTGCAGTTGGAGAACGTGCGAA
TCGGCCAGCCCGCCACCGTCAAGGCTGACATCTACGGCGGCTCGGCCAGCTACCGCGGCGTGGTGGAAGGCTTCTCCGGT
GGTTCCGGCGCGGCGTTCGCGGCCATTCCCGCCCAGAACGCCACGGGCAACTGGATCAAGGTGGTGCAGCGCTTGCCCGT
GCGCATCAAGCTCGATGCGGCGGAGCTGGAAAAGCACCCGCTGAAAGTGGGGCTGTCGATGGTGGTCACGATCGACACCA
GCGCCTCCGGTAGCCAGGCCACCCAGGCCCGTCGGTAA

Upstream 100 bases:

>100_bases
GCAATCCCGCGCCTTCACGCTGGACGTTGCCATGACCCGCGCCCTGGGCGGCGGCTACCGCGCGCCCCGCAGCTAAGAAC
CCTCAAGAAACGAGAGCACC

Downstream 100 bases:

>100_bases
AGGAGGGGCCTCATGACTACCCCGTCTTCAGACAGCCAGGCGCCCCTGACCGGGGGAATGCTGTGGTTGGCGGCCATTGT
TCTCGCGGCGGCCAACTTCG

Product: multidrug resistance transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSDNNQTADATAAAPSKQRRARLFLILAAVVAAGAIGGTAYWQLYASRFVSTDNAYAAVEIAQVTPAIDGTIAEVRVSDT
QAVKKGDVLVVIDPTDAKLALEQAEAQLGSAVRRVRGYVANDSSLGAQIIAREADEKRAAADLFSAQADFERAKIDLRRR
EALVASGSVSGEELTKARNAHATADAARAAPASAQARANRNAAVGSRQANAVLIANATEDTNPEVALARAKRDQAAVDLG
RTVIRAPVDGVVAKRQVQLGQRVKSGTALLSIVPVQDMHVDANFKEVQLENVRIGQPATVKADIYGGSASYRGVVEGFSG
GSGAAFAAIPAQNATGNWIKVVQRLPVRIKLDAAELEKHPLKVGLSMVVTIDTSASGSQATQARR

Sequences:

>Translated_385_residues
MSDNNQTADATAAAPSKQRRARLFLILAAVVAAGAIGGTAYWQLYASRFVSTDNAYAAVEIAQVTPAIDGTIAEVRVSDT
QAVKKGDVLVVIDPTDAKLALEQAEAQLGSAVRRVRGYVANDSSLGAQIIAREADEKRAAADLFSAQADFERAKIDLRRR
EALVASGSVSGEELTKARNAHATADAARAAPASAQARANRNAAVGSRQANAVLIANATEDTNPEVALARAKRDQAAVDLG
RTVIRAPVDGVVAKRQVQLGQRVKSGTALLSIVPVQDMHVDANFKEVQLENVRIGQPATVKADIYGGSASYRGVVEGFSG
GSGAAFAAIPAQNATGNWIKVVQRLPVRIKLDAAELEKHPLKVGLSMVVTIDTSASGSQATQARR
>Mature_384_residues
SDNNQTADATAAAPSKQRRARLFLILAAVVAAGAIGGTAYWQLYASRFVSTDNAYAAVEIAQVTPAIDGTIAEVRVSDTQ
AVKKGDVLVVIDPTDAKLALEQAEAQLGSAVRRVRGYVANDSSLGAQIIAREADEKRAAADLFSAQADFERAKIDLRRRE
ALVASGSVSGEELTKARNAHATADAARAAPASAQARANRNAAVGSRQANAVLIANATEDTNPEVALARAKRDQAAVDLGR
TVIRAPVDGVVAKRQVQLGQRVKSGTALLSIVPVQDMHVDANFKEVQLENVRIGQPATVKADIYGGSASYRGVVEGFSGG
SGAAFAAIPAQNATGNWIKVVQRLPVRIKLDAAELEKHPLKVGLSMVVTIDTSASGSQATQARR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=354, Percent_Identity=37.0056497175141, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789041, Length=381, Percent_Identity=39.3700787401575, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1790519, Length=339, Percent_Identity=28.9085545722714, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081951, Length=332, Percent_Identity=25.3012048192771, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789637, Length=168, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40294; Mature: 40163

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNNQTADATAAAPSKQRRARLFLILAAVVAAGAIGGTAYWQLYASRFVSTDNAYAAVE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
IAQVTPAIDGTIAEVRVSDTQAVKKGDVLVVIDPTDAKLALEQAEAQLGSAVRRVRGYVA
EEECCCCCCCCEEEEEECCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEC
NDSSLGAQIIAREADEKRAAADLFSAQADFERAKIDLRRREALVASGSVSGEELTKARNA
CCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCC
HATADAARAAPASAQARANRNAAVGSRQANAVLIANATEDTNPEVALARAKRDQAAVDLG
CCCHHHHHCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHH
RTVIRAPVDGVVAKRQVQLGQRVKSGTALLSIVPVQDMHVDANFKEVQLENVRIGQPATV
HHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCEEEEEEEECCCCCEE
KADIYGGSASYRGVVEGFSGGSGAAFAAIPAQNATGNWIKVVQRLPVRIKLDAAELEKHP
EEEEECCCCCCCHHEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHHHCCC
LKVGLSMVVTIDTSASGSQATQARR
CEECEEEEEEEECCCCCCCHHCCCC
>Mature Secondary Structure 
SDNNQTADATAAAPSKQRRARLFLILAAVVAAGAIGGTAYWQLYASRFVSTDNAYAAVE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
IAQVTPAIDGTIAEVRVSDTQAVKKGDVLVVIDPTDAKLALEQAEAQLGSAVRRVRGYVA
EEECCCCCCCCEEEEEECCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEC
NDSSLGAQIIAREADEKRAAADLFSAQADFERAKIDLRRREALVASGSVSGEELTKARNA
CCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCC
HATADAARAAPASAQARANRNAAVGSRQANAVLIANATEDTNPEVALARAKRDQAAVDLG
CCCHHHHHCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHH
RTVIRAPVDGVVAKRQVQLGQRVKSGTALLSIVPVQDMHVDANFKEVQLENVRIGQPATV
HHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCEEEEEEEECCCCCEE
KADIYGGSASYRGVVEGFSGGSGAAFAAIPAQNATGNWIKVVQRLPVRIKLDAAELEKHP
EEEEECCCCCCCHHEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHHHCCC
LKVGLSMVVTIDTSASGSQATQARR
CEECEEEEEEEECCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]