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The map label for this gene is patB [H]

Identifier: 17546559

GI number: 17546559

Start: 2019456

End: 2020334

Strand: Direct

Name: patB [H]

Synonym: RSc1840

Alternate gene names: 17546559

Gene position: 2019456-2020334 (Clockwise)

Preceding gene: 17546551

Following gene: 17546560

Centisome position: 54.34

GC content: 65.42

Gene sequence:

>879_bases
ATGACCGGGCACGCCGGCATGCCGCCGATGAAAATAGACCTCCAGCGAATACGGCGGAATCGGAAAGGGCGCCGGATAGA
TCGTCAGCGCAAGCGTGCTGCCCAATGCCAGGGCGACGCGCCGGCGCCGCTCGTCCTGGAAGACGGCCGCTATCGCTTCG
ACGCGGCGATCTTCGAGCAGGCCATTCGTGACGACACGCGGCTGTTCATCCTCTCCAATCCGCACAATCCCACGGGCAAC
GTCTGGTCGGAAGACGACCTGCGCACGATGGGCGAGATCTGCCTGCGCCACGGCATCCTGGTGATCGCCGACGAGATCCA
CCAGGACTTCGTCCTGGCGCCGTCGCGGCGGCACATTCCCTTTGCCGCCCTGGACCCGCGCTTCGCCGCGCACAGCCTGA
CGTGCACCTCGGCCAGCAAGACCTTCAACCTGGCCGGCCTGCAATGCGCAAACCTGATCATTTCCGACCGCCGGCTGCGT
GACACCTTCATCCGGCAACTCGAGCGCAACCAGTTCAACGTAGTCAACCTGCTCGGCATGGTGGCCACCGAGGCGGCCTA
TGCCCAAGGCGAGCCCTGGCTGGAAGCCATGCTGGCTTACATTCGCGCAAACCAGCAGCATTTCGCCGCCACCGTGAACG
CGGCGGACTGGGGCCTGCGCGTGCACGAGATGGACGCGCTTTACCTTGCCTGGATCGACTGCCGTCCGCTTGGCCTGTCG
GCGGAGGCACTGGAGCACTTCATGCTGACCCGCGCGCGCATCTGGTTCGACAAAGGGCAGAAATTCGGCGCCGAAGGGCA
TGGTTTCCTGCGCGCGAACCTGGGCTGTCCGCGGGCCGTTGTCGATGATGCGTTGGCGAGGCTGGCGGGGGCGATGTAG

Upstream 100 bases:

>100_bases
CGCTCGCCGGGCCGTCATCCCGCCGCCCGGATTGAGGCCAATCGGCCTGAAGCTATGGCTTCGCGGCCAAGACCAGGCGC
ATCTGGTCACGCAGCCAGGC

Downstream 100 bases:

>100_bases
GCTGGCTCGGCCGGCGTGCAAGCCCCGGCCGCCAGCACGACGCTGACTACGCTCATGCTTAGAATCCCGAAAGTTTCCGA
TCATGACAACGACTAACCAA

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTGHAGMPPMKIDLQRIRRNRKGRRIDRQRKRAAQCQGDAPAPLVLEDGRYRFDAAIFEQAIRDDTRLFILSNPHNPTGN
VWSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSRRHIPFAALDPRFAAHSLTCTSASKTFNLAGLQCANLIISDRRLR
DTFIRQLERNQFNVVNLLGMVATEAAYAQGEPWLEAMLAYIRANQQHFAATVNAADWGLRVHEMDALYLAWIDCRPLGLS
AEALEHFMLTRARIWFDKGQKFGAEGHGFLRANLGCPRAVVDDALARLAGAM

Sequences:

>Translated_292_residues
MTGHAGMPPMKIDLQRIRRNRKGRRIDRQRKRAAQCQGDAPAPLVLEDGRYRFDAAIFEQAIRDDTRLFILSNPHNPTGN
VWSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSRRHIPFAALDPRFAAHSLTCTSASKTFNLAGLQCANLIISDRRLR
DTFIRQLERNQFNVVNLLGMVATEAAYAQGEPWLEAMLAYIRANQQHFAATVNAADWGLRVHEMDALYLAWIDCRPLGLS
AEALEHFMLTRARIWFDKGQKFGAEGHGFLRANLGCPRAVVDDALARLAGAM
>Mature_291_residues
TGHAGMPPMKIDLQRIRRNRKGRRIDRQRKRAAQCQGDAPAPLVLEDGRYRFDAAIFEQAIRDDTRLFILSNPHNPTGNV
WSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSRRHIPFAALDPRFAAHSLTCTSASKTFNLAGLQCANLIISDRRLRD
TFIRQLERNQFNVVNLLGMVATEAAYAQGEPWLEAMLAYIRANQQHFAATVNAADWGLRVHEMDALYLAWIDCRPLGLSA
EALEHFMLTRARIWFDKGQKFGAEGHGFLRANLGCPRAVVDDALARLAGAM

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=231, Percent_Identity=36.3636363636364, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71994472, Length=116, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=116, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=97, Percent_Identity=35.0515463917526, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI18859735, Length=266, Percent_Identity=24.812030075188, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 32883; Mature: 32752

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGHAGMPPMKIDLQRIRRNRKGRRIDRQRKRAAQCQGDAPAPLVLEDGRYRFDAAIFEQ
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCEEHHHHHHHH
AIRDDTRLFILSNPHNPTGNVWSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSRRHIP
HHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHCCCEEECCCCCCCC
FAALDPRFAAHSLTCTSASKTFNLAGLQCANLIISDRRLRDTFIRQLERNQFNVVNLLGM
EEECCCCHHHCEEEECCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHH
VATEAAYAQGEPWLEAMLAYIRANQQHFAATVNAADWGLRVHEMDALYLAWIDCRPLGLS
HHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEECCHHHCEEEEECCEEEEEEEECCCCCCC
AEALEHFMLTRARIWFDKGQKFGAEGHGFLRANLGCPRAVVDDALARLAGAM
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGHAGMPPMKIDLQRIRRNRKGRRIDRQRKRAAQCQGDAPAPLVLEDGRYRFDAAIFEQ
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCEEHHHHHHHH
AIRDDTRLFILSNPHNPTGNVWSEDDLRTMGEICLRHGILVIADEIHQDFVLAPSRRHIP
HHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHHHCCCEEECCCCCCCC
FAALDPRFAAHSLTCTSASKTFNLAGLQCANLIISDRRLRDTFIRQLERNQFNVVNLLGM
EEECCCCHHHCEEEECCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHH
VATEAAYAQGEPWLEAMLAYIRANQQHFAATVNAADWGLRVHEMDALYLAWIDCRPLGLS
HHHHHHHHCCCHHHHHHHHHHHCCCHHHEEEECCHHHCEEEEECCEEEEEEEECCCCCCC
AEALEHFMLTRARIWFDKGQKFGAEGHGFLRANLGCPRAVVDDALARLAGAM
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]