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The map label for this gene is bioD

Identifier: 17546198

GI number: 17546198

Start: 1586570

End: 1587259

Strand: Direct

Name: bioD

Synonym: RSc1479

Alternate gene names: 17546198

Gene position: 1586570-1587259 (Clockwise)

Preceding gene: 17546197

Following gene: 17546199

Centisome position: 42.69

GC content: 74.64

Gene sequence:

>690_bases
ATGCCGGTGCGCTTCGACTGCTTCGTCACCGGGACCGACACCGAGATCGGCAAGACGCTGGCCAGCGCGGCACTGCTGAC
GGCGCTGGCCGGCGCCGGCTACCGCACCGCGGGGCTCAAGCCGGTCGCCGCCGGCACGCTGGCGGGCGCGCCCGAGCGCA
CCAACGAAGACATCGAACAACTGCGCGCTGCCGCCACCGTCGGCCTGCCGATGGCGACGCTCTGCCCGTGGCTGCTCGAC
GCGCCGATGTCGCCGCACCTGGCGGCCCGGCGCGCGGGCGTGACGATCACGCTGCCGCCCATCGTCGATGCGCTGGCGCA
GGCCCGGACACAGGCCGACGCGGTGGTCGTTGAAGGCGTCGGCGGCTTCCGCGTGCCGCTGTCGGATACGTTCGATACGG
CGCAGCTGGCGGTGGCGCTCGGCCTGCCGGTGGTGCTGGTGGTCGGCCTGCGCCTGGGCTGCCTGAACCACGCCGCGCTG
ACGGCCGAGGCCATTGCCGCACGCGGCCTGCGCCTGGCCGGCTGGATCGGCAACGTGGTCGACGCCACCATGGCCGGGCT
GGACGACAACGTGGCCACCCTGCGCCGCTGGATCGACGCGCCGCACCTGGGCACGATCCCGCGTCTGCCGCGCCCGGACG
CGCGCCTGGCCGCGTCGCACGTGGATATCGCACCGCTGCTGGCGCGCTGA

Upstream 100 bases:

>100_bases
ACCCTGTCCGCCGCGCACACCGAGGACGACATCGAGCGGCTGGCCCGCGCGCTGGAGGCGGCCGGCCAATCGCAGCAATC
CGCCGCCCGCGCTGCCTGAC

Downstream 100 bases:

>100_bases
AACGCCGGGCAGCGCTACACTGTCCAACTTCACGAGATTTCGATCACGCTTGGATGGAGACGGCTGTCATGCGCGCAATG
CGTTGGCTGGCGGTGGCCTG

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MPVRFDCFVTGTDTEIGKTLASAALLTALAGAGYRTAGLKPVAAGTLAGAPERTNEDIEQLRAAATVGLPMATLCPWLLD
APMSPHLAARRAGVTITLPPIVDALAQARTQADAVVVEGVGGFRVPLSDTFDTAQLAVALGLPVVLVVGLRLGCLNHAAL
TAEAIAARGLRLAGWIGNVVDATMAGLDDNVATLRRWIDAPHLGTIPRLPRPDARLAASHVDIAPLLAR

Sequences:

>Translated_229_residues
MPVRFDCFVTGTDTEIGKTLASAALLTALAGAGYRTAGLKPVAAGTLAGAPERTNEDIEQLRAAATVGLPMATLCPWLLD
APMSPHLAARRAGVTITLPPIVDALAQARTQADAVVVEGVGGFRVPLSDTFDTAQLAVALGLPVVLVVGLRLGCLNHAAL
TAEAIAARGLRLAGWIGNVVDATMAGLDDNVATLRRWIDAPHLGTIPRLPRPDARLAASHVDIAPLLAR
>Mature_228_residues
PVRFDCFVTGTDTEIGKTLASAALLTALAGAGYRTAGLKPVAAGTLAGAPERTNEDIEQLRAAATVGLPMATLCPWLLDA
PMSPHLAARRAGVTITLPPIVDALAQARTQADAVVVEGVGGFRVPLSDTFDTAQLAVALGLPVVLVVGLRLGCLNHAALT
AEAIAARGLRLAGWIGNVVDATMAGLDDNVATLRRWIDAPHLGTIPRLPRPDARLAASHVDIAPLLAR

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI1786995, Length=227, Percent_Identity=44.0528634361233, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87081944, Length=226, Percent_Identity=38.9380530973451, Blast_Score=140, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD_RALSO (Q8XZC2)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519600.1
- ProteinModelPortal:   Q8XZC2
- GeneID:   1220308
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1479
- NMPDR:   fig|267608.1.peg.1479
- HOGENOM:   HBG650065
- OMA:   GWIANNI
- ProtClustDB:   PRK00090
- BioCyc:   RSOL267608:RSC1479-MONOMER
- BRENDA:   6.3.3.3
- HAMAP:   MF_00336
- InterPro:   IPR004472
- InterPro:   IPR002586
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: PF01656 CbiA

EC number: =6.3.3.3

Molecular weight: Translated: 23621; Mature: 23490

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRFDCFVTGTDTEIGKTLASAALLTALAGAGYRTAGLKPVAAGTLAGAPERTNEDIEQ
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHH
LRAAATVGLPMATLCPWLLDAPMSPHLAARRAGVTITLPPIVDALAQARTQADAVVVEGV
HHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEECHHHHHHHHHHHHHCCEEEEECC
GGFRVPLSDTFDTAQLAVALGLPVVLVVGLRLGCLNHAALTAEAIAARGLRLAGWIGNVV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DATMAGLDDNVATLRRWIDAPHLGTIPRLPRPDARLAASHVDIAPLLAR
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
PVRFDCFVTGTDTEIGKTLASAALLTALAGAGYRTAGLKPVAAGTLAGAPERTNEDIEQ
CEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHH
LRAAATVGLPMATLCPWLLDAPMSPHLAARRAGVTITLPPIVDALAQARTQADAVVVEGV
HHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEECHHHHHHHHHHHHHCCEEEEECC
GGFRVPLSDTFDTAQLAVALGLPVVLVVGLRLGCLNHAALTAEAIAARGLRLAGWIGNVV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DATMAGLDDNVATLRRWIDAPHLGTIPRLPRPDARLAASHVDIAPLLAR
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852