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The map label for this gene is bioA [H]

Identifier: 17546196

GI number: 17546196

Start: 1583925

End: 1585331

Strand: Direct

Name: bioA [H]

Synonym: RSc1477

Alternate gene names: 17546196

Gene position: 1583925-1585331 (Clockwise)

Preceding gene: 17546194

Following gene: 17546197

Centisome position: 42.62

GC content: 70.79

Gene sequence:

>1407_bases
ATGGCGTATCCCCCCATCCCCGTGCCGGCGGACGCCGCGCCCAGTGCCAACACGGCGTGGCAGGCGCGCAGCCGCGCGGC
GGTCTGGCACCCGTGCACGCAGAACGCGCGGCTCGATGCCATGCCGCCGCTGCCGATCGCGCGCGGCCAGGGGCCGTGGC
TGATCGACTTCGACGGCAAGCGCTACCTGGACGGCACCAGCTCGTGGTGGGTCAACCTGTTCGGCCATGCCAATCCGCAC
ATCAACGCTGCGCTCAAGGCGCAGCTGGACATGCTGGAGCACACCATGCTGGCCGGCGCCACGCATCGCCCGGCGGTGGA
GCTGGCAGAGCGCCTGGTCGGGCTGACGGGCGGCGTGCTCGGGCATAGCTTCTTCGGCTCGGACGGCGCCTCGGCGGTGG
AGATCGCGCTCAAGATGAGCTTTCATGCTCACCGCAACGCGGGGCAGGGCGCGCGCAGCCGCTTCGTCTGCCTGGAGCAC
GGCTACCACGGCGAGACCCTCGGCGCGCTGGGCGTGACCGACGTGGCGATCTTCCGCGATGCCTACGATCCGCTGATCCT
GCAATCGCATCGCGTGGCGTCGCCCGATGCCCGGCTGGCCGGCCCAGGCGAGACCGGCGCCGATGTGGCCGAGCGCGCGC
TGGCCGCCCTGCGCGATTGCCTGTCGGCCAACGCCGGCACCATCGCCGCCGTCATCATCGAGCCGCTGGTGCAGTGCGCC
GCCGGCATGGCGATGCACGACGCCAGCTACCTGCGCGGCGTGCGCGCGCTGTGCGATCAGTTCGGCGTGCACTGGATCGC
CGACGAGATCGCCGTGGGCTGCGGCCGCACCGGCACCTTCTTCGCCTGCGAGCAGGCGGGCGTGTGGCCGGACCTGCTGT
GCCTGTCCAAGGGCATCAGCGGGGGCTATCTGCCGCTGTCGATCGTGCTGTCGCGCGATGCCATCTATGACGCCTTCAAC
GAAGACGCGCCGGTGCGCAGCTTCCTGCATTCGCACTCGTACACCGGCAACCCGCTGGCCTGCCGCGCGGCGCTGGCCAC
GCTCGACCTGTTCGCGGAGGAAGACGTCTTCGCCCGCAACCGCGTCACCGCTGCCCGCATCGCCCAGGGGCTGGCGCCGC
TGTCGCACGATGCGCGCTTTGCCCACCTGCGGCAGGCCGGCATGATCACCGCGTTCGATGTGCACCCCGAAGTGGCCGGC
CCGCGCTTTGCCGAGCGCTTCGCGCTGACGGCGCGCGCGCATGGCCTGCTGCTGCGGCCTATCGGGCACACCGTCTACCT
GCTGCCGCCCTACGTGCTGACCGACGACGAAACCGACACCCTGGTCGAACGCACGCTGCACACCCTCGAAGACACGCTTG
CGCAAGCCACCGGCGCGCACGAAGGAGAAACCCATGCGATTGCTTGA

Upstream 100 bases:

>100_bases
TCGCCGAATGGCATGCCGCCTACCATACGCCGCCATGTGCCGGCCCCGTGCAGCCTCGCGCTTTGCAGCGAGCGGCCGGC
CTCGCTACCAGGAGGTTCGT

Downstream 100 bases:

>100_bases
CGACCTGCGGGCCGGCCTGGACGCCATCGACGCCGCGCACCTGCGTCGCGTGCGCCGCACCGCCTACAGCCCCACCGACC
GCAGCCAGCGCATCGACGTG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAYPPIPVPADAAPSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHANPH
INAALKAQLDMLEHTMLAGATHRPAVELAERLVGLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGQGARSRFVCLEH
GYHGETLGALGVTDVAIFRDAYDPLILQSHRVASPDARLAGPGETGADVAERALAALRDCLSANAGTIAAVIIEPLVQCA
AGMAMHDASYLRGVRALCDQFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDAIYDAFN
EDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQAGMITAFDVHPEVAG
PRFAERFALTARAHGLLLRPIGHTVYLLPPYVLTDDETDTLVERTLHTLEDTLAQATGAHEGETHAIA

Sequences:

>Translated_468_residues
MAYPPIPVPADAAPSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHANPH
INAALKAQLDMLEHTMLAGATHRPAVELAERLVGLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGQGARSRFVCLEH
GYHGETLGALGVTDVAIFRDAYDPLILQSHRVASPDARLAGPGETGADVAERALAALRDCLSANAGTIAAVIIEPLVQCA
AGMAMHDASYLRGVRALCDQFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDAIYDAFN
EDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQAGMITAFDVHPEVAG
PRFAERFALTARAHGLLLRPIGHTVYLLPPYVLTDDETDTLVERTLHTLEDTLAQATGAHEGETHAIA
>Mature_467_residues
AYPPIPVPADAAPSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGKRYLDGTSSWWVNLFGHANPHI
NAALKAQLDMLEHTMLAGATHRPAVELAERLVGLTGGVLGHSFFGSDGASAVEIALKMSFHAHRNAGQGARSRFVCLEHG
YHGETLGALGVTDVAIFRDAYDPLILQSHRVASPDARLAGPGETGADVAERALAALRDCLSANAGTIAAVIIEPLVQCAA
GMAMHDASYLRGVRALCDQFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGISGGYLPLSIVLSRDAIYDAFNE
DAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARNRVTAARIAQGLAPLSHDARFAHLRQAGMITAFDVHPEVAGP
RFAERFALTARAHGLLLRPIGHTVYLLPPYVLTDDETDTLVERTLHTLEDTLAQATGAHEGETHAIA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=30.1932367149758, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI284507298, Length=224, Percent_Identity=33.4821428571429, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=446, Percent_Identity=25.3363228699552, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI226442705, Length=446, Percent_Identity=25.5605381165919, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI226442709, Length=412, Percent_Identity=24.7572815533981, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=34.3529411764706, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=31.0606060606061, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=29.1358024691358, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=25.9803921568627, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=28.361858190709, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787560, Length=415, Percent_Identity=29.6385542168675, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=28.2420749279539, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=429, Percent_Identity=28.2051282051282, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=422, Percent_Identity=26.0663507109005, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=243, Percent_Identity=28.8065843621399, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=22.1967963386728, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=27.7899343544858, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323470, Length=440, Percent_Identity=29.0909090909091, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324432, Length=425, Percent_Identity=25.4117647058824, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=28.3653846153846, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=26.7415730337079, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574759, Length=356, Percent_Identity=28.0898876404494, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=25.3554502369668, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50037; Mature: 49906

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPPIPVPADAAPSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGK
CCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
RYLDGTSSWWVNLFGHANPHINAALKAQLDMLEHTMLAGATHRPAVELAERLVGLTGGVL
EEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
GHSFFGSDGASAVEIALKMSFHAHRNAGQGARSRFVCLEHGYHGETLGALGVTDVAIFRD
HHHHCCCCCCHHEEEEEHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHH
AYDPLILQSHRVASPDARLAGPGETGADVAERALAALRDCLSANAGTIAAVIIEPLVQCA
CCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AGMAMHDASYLRGVRALCDQFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGIS
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCC
GGYLPLSIVLSRDAIYDAFNEDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARN
CCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
RVTAARIAQGLAPLSHDARFAHLRQAGMITAFDVHPEVAGPRFAERFALTARAHGLLLRP
CHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEE
IGHTVYLLPPYVLTDDETDTLVERTLHTLEDTLAQATGAHEGETHAIA
CCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AYPPIPVPADAAPSANTAWQARSRAAVWHPCTQNARLDAMPPLPIARGQGPWLIDFDGK
CCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
RYLDGTSSWWVNLFGHANPHINAALKAQLDMLEHTMLAGATHRPAVELAERLVGLTGGVL
EEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
GHSFFGSDGASAVEIALKMSFHAHRNAGQGARSRFVCLEHGYHGETLGALGVTDVAIFRD
HHHHCCCCCCHHEEEEEHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHH
AYDPLILQSHRVASPDARLAGPGETGADVAERALAALRDCLSANAGTIAAVIIEPLVQCA
CCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AGMAMHDASYLRGVRALCDQFGVHWIADEIAVGCGRTGTFFACEQAGVWPDLLCLSKGIS
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCC
GGYLPLSIVLSRDAIYDAFNEDAPVRSFLHSHSYTGNPLACRAALATLDLFAEEDVFARN
CCCCEEEEEEEHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
RVTAARIAQGLAPLSHDARFAHLRQAGMITAFDVHPEVAGPRFAERFALTARAHGLLLRP
CHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEE
IGHTVYLLPPYVLTDDETDTLVERTLHTLEDTLAQATGAHEGETHAIA
CCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]