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The map label for this gene is hipA [H]

Identifier: 17546165

GI number: 17546165

Start: 1548504

End: 1549841

Strand: Reverse

Name: hipA [H]

Synonym: RSc1446

Alternate gene names: 17546165

Gene position: 1549841-1548504 (Counterclockwise)

Preceding gene: 17546166

Following gene: 17546164

Centisome position: 41.7

GC content: 71.6

Gene sequence:

>1338_bases
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGACCGCATCGACAGCGAGGCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCATGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCTACAGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Upstream 100 bases:

>100_bases
CGGCTTCGAGCAGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCGCCCGCCGCCGCCG
CGCCCGCCGACTGGTAAGCC

Downstream 100 bases:

>100_bases
CCGCAAACCCGCGCCCCGACGTCCTGCGCCGCCTGCCGCCCGGCATCTGGGTTCTGGGTGGCGTCAGCCTGCTGATGGAC
GTCGCCTCCGAGATGATCCA

Product: HIPA transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Sequences:

>Translated_445_residues
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP
>Mature_444_residues
AHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVRR
RFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGAQ
EKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERFD
RRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFSL
AIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVER
VPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=444, Percent_Identity=41.4414414414414, Blast_Score=309, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 48743; Mature: 48612

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQV
CCCCCEEEEECCCEEEEEEECCCCCCEEEECHHHHCCCCCCEEEEECCCCCCCHHHHHHH
VDDYFDNLLPEAQPIRERVRRRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRI
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
DSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGAQEKTALLRIGDAWHRPLGAT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHEEEECHHHCCCCCCC
PTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFV
HCCCCCCCCCEEECCHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
LAQLAFWLLAATDGHAKNFSLAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAM
HHHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVERVPAGLERVEAILPPDFSGR
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCH
VWSSVRTGVLAQAERFLNELASVTP
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQV
CCCCEEEEECCCEEEEEEECCCCCCEEEECHHHHCCCCCCEEEEECCCCCCCHHHHHHH
VDDYFDNLLPEAQPIRERVRRRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRI
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCC
DSEALTDSQVDTLLRNLTAMPALGEDAGDPDAFRISIAGAQEKTALLRIGDAWHRPLGAT
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHEEEECHHHCCCCCCC
PTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFV
HCCCCCCCCCEEECCHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
LAQLAFWLLAATDGHAKNFSLAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAM
HHHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVERVPAGLERVEAILPPDFSGR
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCH
VWSSVRTGVLAQAERFLNELASVTP
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]