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The map label for this gene is guaA [H]

Identifier: 17546150

GI number: 17546150

Start: 1530159

End: 1531802

Strand: Direct

Name: guaA [H]

Synonym: RSc1431

Alternate gene names: 17546150

Gene position: 1530159-1531802 (Clockwise)

Preceding gene: 17546149

Following gene: 17546151

Centisome position: 41.17

GC content: 65.69

Gene sequence:

>1644_bases
TTGCCGATTCTCTCCCTCCACAACATGCACGACAAAGTCCTCATCCTTGATTTCGGCTCGCAGGTCACGCAGCTGATCGC
GCGGCGTGTCCGCGAAGCGCACGTCTACTGCGAGATCCATCCGAACGACGTGTCCGACGCCTTCGTGCGCGAGTTCGCAC
CCAAGGCCATCATCCTCTCCGGCAGCCACGCCAGCACCTACGAAGACCAGGATCTGCGTGCCCCGCAGGCGGTATGGGAC
CTGGGTGTGCCGGTGCTCGGCATCTGCTACGGCATGTTCGCGATGACGGTGCAGCAGGGCGGCAAGGTGGAAGCCAGCGC
GCACCGCGAGTTCGGCTATGCCGAAGTGCGCGCGCATGGCCATACCCGTCTGCTGGACAGCATCGAAGATTTCCGCACCC
CCGAAGGCCACGGCATGCTGAAGGTGTGGATGAGCCACGGCGACAAGGTCACCGAGATGCCGCCGGGCTTCAAGCTGATG
GCCTCCACGCCGAGCTGCCCGATCGCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCCGTGCAGTTCCACCCGGAAGT
CACGCACACCGTGCAGGGCCGCGCGCTGCTTGAGCGCTTCGTGCTCGAGATCGCCGGCGCCAAGCCGGACTGGATCATGC
GCGACCACATCGAAGAGGCGGTCAAGTCGATCCGCGAGCAGGTGGGCGACGAAGAGGTGATCCTGGGCCTGTCGGGCGGC
GTCGATTCGTCGGTGGCCGCGGCGCTGATCCATCGCGCCATCGGCGACCAGCTGACGTGCGTGTTCGTCGATCACGGCCT
GCTGCGCCTGAACGAAGGCCAGATGGTGCTCGACATGTTCGAGGGCCGGCTGCATGCCAAGGTCGTGCACGTCGATGCGT
CCGAACAGTTCCTTGGCCACCTGACCGGCGTGACCGATCCGGAAGCCAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAA
GTGTTCCAGGCCGAGGCCAAGACGCTGACCAATGCGAAGTGGCTGGCGCAGGGCACGATCTACCCGGACGTGATCGAATC
GGGTGGCGCCAAGACCAAGAAGGCGACCACGATCAAGAGCCACCACAACGTCGGCGGCCTGCCCGAGACCCTGGGCCTGA
AGCTGCTGGAGCCGCTACGCGACCTCTTCAAGGACGAGGTGCGCGAGCTGGGCGTCGCGCTCGGCCTGCCGCCCGAGATG
GTGTACCGCCATCCGTTCCCGGGCCCGGGCCTGGGCGTGCGCATCCTGGGCGAGGTCAAGCGTGAATACGCGGATCTGCT
GCGCCGTGCCGATGCCATCTTTATCGAAGAGCTGCGCGGCACCAAAGCCACCGCGCAGGATGCTGTCGCGGGCCTGTGCA
CCGAAGATCAGGTCGGCAAGAGCTGGTACGACCTGACTAGCCAGGCGTTTGCGGTGTTCCTGCCGGTCAAGTCGGTCGGC
GTGATGGGCGATGGCCGTACCTATGACTACGTGGTCGCCCTGCGCGCGGTGCAGACCACCGACTTCATGACGGCACACTG
GGCGCACTTGCCGTATGCGCTGCTGGGTCGGGTGTCGAACCGCATCATCAATGAGGTGCGGGGCATCAACCGCGTGGTGT
ACGACGTGTCGGGCAAGCCGCCGGCCACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCGGCCGCCACGCGTGAACGCGAACGCGCGGGCGCCGAGCGCAAGGAACCCGCCTATATGCCGCCGCCGGGCTACGGCCC
CGGCACCGAAGTCGACACGA

Downstream 100 bases:

>100_bases
TCCCAGCCTGTCGGATGACTGGCGCCCTTTGATCGGCATCGCCAAATTCCCAGCAATAAGGCGGTCCGGGTAACGGCACT
GGAAGTGGTTGAAATTACCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MPILSLHNMHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDQDLRAPQAVWD
LGVPVLGICYGMFAMTVQQGGKVEASAHREFGYAEVRAHGHTRLLDSIEDFRTPEGHGMLKVWMSHGDKVTEMPPGFKLM
ASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWIMRDHIEEAVKSIREQVGDEEVILGLSGG
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFEGRLHAKVVHVDASEQFLGHLTGVTDPEAKRKIIGREFVE
VFQAEAKTLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEM
VYRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAVAGLCTEDQVGKSWYDLTSQAFAVFLPVKSVG
VMGDGRTYDYVVALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_547_residues
MPILSLHNMHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDQDLRAPQAVWD
LGVPVLGICYGMFAMTVQQGGKVEASAHREFGYAEVRAHGHTRLLDSIEDFRTPEGHGMLKVWMSHGDKVTEMPPGFKLM
ASTPSCPIAGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWIMRDHIEEAVKSIREQVGDEEVILGLSGG
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFEGRLHAKVVHVDASEQFLGHLTGVTDPEAKRKIIGREFVE
VFQAEAKTLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEM
VYRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAVAGLCTEDQVGKSWYDLTSQAFAVFLPVKSVG
VMGDGRTYDYVVALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_546_residues
PILSLHNMHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDQDLRAPQAVWDL
GVPVLGICYGMFAMTVQQGGKVEASAHREFGYAEVRAHGHTRLLDSIEDFRTPEGHGMLKVWMSHGDKVTEMPPGFKLMA
STPSCPIAGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWIMRDHIEEAVKSIREQVGDEEVILGLSGGV
DSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFEGRLHAKVVHVDASEQFLGHLTGVTDPEAKRKIIGREFVEV
FQAEAKTLTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMV
YRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAVAGLCTEDQVGKSWYDLTSQAFAVFLPVKSVGV
MGDGRTYDYVVALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=569, Percent_Identity=34.4463971880492, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1788854, Length=541, Percent_Identity=63.4011090573013, Blast_Score=682, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=34.8275862068965, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=34.8275862068965, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=34.8275862068965, Blast_Score=283, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.4452554744526, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.1785714285714, Blast_Score=281, Evalue=6e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 60361; Mature: 60230

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPILSLHNMHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILS
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCEEEEE
GSHASTYEDQDLRAPQAVWDLGVPVLGICYGMFAMTVQQGGKVEASAHREFGYAEVRAHG
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEECHHHHCCCCHHHHHCC
HTRLLDSIEDFRTPEGHGMLKVWMSHGDKVTEMPPGFKLMASTPSCPIAGMADEARGYYA
HHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCCCCCCEEE
VQFHPEVTHTVQGRALLERFVLEIAGAKPDWIMRDHIEEAVKSIREQVGDEEVILGLSGG
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFEGRLHAKVVHVDASEQFLGH
CCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHCCCEEEEEEEECCHHHHHHH
LTGVTDPEAKRKIIGREFVEVFQAEAKTLTNAKWLAQGTIYPDVIESGGAKTKKATTIKS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCHHHHHCCCCCCCHHEEECC
HHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
REYADLLRRADAIFIEELRGTKATAQDAVAGLCTEDQVGKSWYDLTSQAFAVFLPVKSVG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCHHHHHHHHHHEEEEEEHHHHC
VMGDGRTYDYVVALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKP
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PATIEWE
CCEEECC
>Mature Secondary Structure 
PILSLHNMHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILS
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHCCCCEEEEE
GSHASTYEDQDLRAPQAVWDLGVPVLGICYGMFAMTVQQGGKVEASAHREFGYAEVRAHG
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEECHHHHCCCCHHHHHCC
HTRLLDSIEDFRTPEGHGMLKVWMSHGDKVTEMPPGFKLMASTPSCPIAGMADEARGYYA
HHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCEEEECCCCCCCCCCCCCCCCEEE
VQFHPEVTHTVQGRALLERFVLEIAGAKPDWIMRDHIEEAVKSIREQVGDEEVILGLSGG
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFEGRLHAKVVHVDASEQFLGH
CCHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHCCCEEEEEEEECCHHHHHHH
LTGVTDPEAKRKIIGREFVEVFQAEAKTLTNAKWLAQGTIYPDVIESGGAKTKKATTIKS
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCHHHHHCCCCCCCHHEEECC
HHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
REYADLLRRADAIFIEELRGTKATAQDAVAGLCTEDQVGKSWYDLTSQAFAVFLPVKSVG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCHHHHHHHHHHEEEEEEHHHHC
VMGDGRTYDYVVALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKP
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PATIEWE
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA