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The map label for this gene is rluF [H]

Identifier: 17546120

GI number: 17546120

Start: 1497887

End: 1499782

Strand: Reverse

Name: rluF [H]

Synonym: RSc1401

Alternate gene names: 17546120

Gene position: 1499782-1497887 (Counterclockwise)

Preceding gene: 17546121

Following gene: 17546113

Centisome position: 40.36

GC content: 72.15

Gene sequence:

>1896_bases
ATGACTGATTCCGACGATTTCCCCGGCGACGACACCAAGCGCTCCGCCAGCGACCCCACGCAGCGGGCCACCCGCCCGGG
CAAGCGCGCCACGCTCGGCGTGCGCCGCGACGACACGGGCAACCCGGTGCGCACCACCGGCAAGCCGCTGCGCGCCTCCG
ACCTGAACCGCGACCGCCAGCCGCTGCGCCCGTCGCAACGCCGGCCCAAGCCGCAGGAAGGCGACGCCAAGCGGCCCGCC
CGAGCGCGCCGCGACGACGACAGCCAGCCGCCGCGCGAGGCCAAGCCGCGCCGCATGCAGGGGGACCGCCCGCCGCGCCG
GTTCGAGGACCGTCCGCCGCGTCGATTCGATGACGAACGTCCGCCGCGCAAGTTCGGCGACGATCAACGTCCGCCCCGTC
GCTTCGGCGATGAGCGGCCGCCTCGCCGGTTCGAGGACCGTCCTCCGCGCCGATTCGATGACGAACGTCCGCCGCGCAAG
TTCGGCGACGATCAACGTCCGCCCCGTCGCTTCGGCGATGAGCAGCCGCCTCGCCGGTTCGAGGACCGTCCTCCGCGCCG
ATTCGATGACGAGCGGCCGCCGCGCAAGTTCGGCGACGATCAACGTCCGCCGCGTCGGTTTGACGATGAGCGGCCGCCTC
GCCGGTTCGAGGACCGTCCGCCGCGCCGATTCGATGACGAGCGGCCGCCGCGCAAGTTCGGCGACGATCAACGTCCGCCC
CGTCGCTTCGGCGATGAGCGACCACCCCGCCGGTTCGAGGACCGTCCGCCGCGCCGATTCGATGACGAACGGCCGCCGCG
CAGGTCCGGCGACGATCAACGTCCGCCCCGTCGCTTCGGCGACGAGCGGCCTCCACGCCGTTTCGAGGACCGCCCACCGC
GCCGGTTCGATGACGAACGGCCACCGCGCAGGTCCGGCGACGATCAACGCCCGCCCCGTCGCTTCGAGGACCGTCCTCCG
CGCCGGTTCGATGACGAACGGCCGCCGCGCAGGTCCGGTGATGATCAGCGCCCTCCGCGCCGCTTCGAGGACCGTCCGGC
CCGCGCGCCGCGCCCCGAACGCGATGAGCGCGCGCCCCAACGCGAGGCGGCACACACGCCCGGTTCGGCACCCCTGGCGG
AATCGTCGGGCCTGGTGCGGCTGTCCAAGCGCATGTCCGAGCTGGGCCTGTGCTCGCGCCGCGAGGCGGACGAGTGGATT
CCGCGCGGCTGGGTGCTGGTGGACGGCGAGCCCGTCACCGAACTGGGTTCGCGCGTGCGACCGGATGCCGAGATCGAGAT
CCTCCCGGCCGCGCGCTCCGAACAGGGCGAGCGCGTGACGGTGCTGCTGCACAAGCCCGTGGGCTATGTGTCGGGCCAGG
CGGAAGACGGCTACGAGCCCGCCGCCGCGCTGTTCACGGCGGAGAACCAGTGGGAGGAGGATCCGACCCGCAAGCATTTC
GCCGCCTGGCAGCACAAGGGCCTGGCGCCGGCCGGCCGGCTGGACATCGACTCCACCGGCCTGCTGGTGCTGACGCAGGA
CGGCCGCGTGGCGCGCCACCTGATCGGCGAAGACTCGACCGTCGAGAAGGAATACCTGGTGCGCGTGGTGTGGAATGCGC
CGCAGGGCCCCGTCGAGCACGACATCTCCAAGGTCTTCCCCGAAGACCTGCTGGAGATGCTGCGCCACGGCCTGTCGCTG
GACGGCGAGGCGCTCAAGCCCGCCAAGGTCAGCTGGCAGAACGAAGAGCAGCTGCGCTTCGTGCTGCGCGAAGGCAAGAA
GCGCCAGATCCGCCGGATGTGCGAGCAGGTCGGCCTGGAGGTGGTGGGCCTCAAGCGCATCCGTATGGGCAGCGTCGTGC
TGGGCGACCTGCCGGTGGGCAAGTGGCGCTTCCTGGGCCGCTTCGAGAAGTTCTGA

Upstream 100 bases:

>100_bases
CGGCCGCCGACTCACGCAGGACAACAAACTGCAGCTCGCGCTCGAAAGCGAGCTGCTCGAGGCACTCGCTATCTGAGGCC
TCGCCTGATGGATTTGACCC

Downstream 100 bases:

>100_bases
GGCGGCACCGTCCCTTCATGAACGGCGCCGGACCGCACGGCCGGCGCCGCCCGCCCCGACTCCGATCGCGTTAAGGCTGC
GGTGGCCGGCAGGCCGCGCC

Product: hypothetical protein

Products: NA

Alternate protein names: rRNA pseudouridylate synthase F; rRNA-uridine isomerase F [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MTDSDDFPGDDTKRSASDPTQRATRPGKRATLGVRRDDTGNPVRTTGKPLRASDLNRDRQPLRPSQRRPKPQEGDAKRPA
RARRDDDSQPPREAKPRRMQGDRPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRK
FGDDQRPPRRFGDEQPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFDDERPPRRFEDRPPRRFDDERPPRKFGDDQRPP
RRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFEDRPP
RRFDDERPPRRSGDDQRPPRRFEDRPARAPRPERDERAPQREAAHTPGSAPLAESSGLVRLSKRMSELGLCSRREADEWI
PRGWVLVDGEPVTELGSRVRPDAEIEILPAARSEQGERVTVLLHKPVGYVSGQAEDGYEPAAALFTAENQWEEDPTRKHF
AAWQHKGLAPAGRLDIDSTGLLVLTQDGRVARHLIGEDSTVEKEYLVRVVWNAPQGPVEHDISKVFPEDLLEMLRHGLSL
DGEALKPAKVSWQNEEQLRFVLREGKKRQIRRMCEQVGLEVVGLKRIRMGSVVLGDLPVGKWRFLGRFEKF

Sequences:

>Translated_631_residues
MTDSDDFPGDDTKRSASDPTQRATRPGKRATLGVRRDDTGNPVRTTGKPLRASDLNRDRQPLRPSQRRPKPQEGDAKRPA
RARRDDDSQPPREAKPRRMQGDRPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRK
FGDDQRPPRRFGDEQPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFDDERPPRRFEDRPPRRFDDERPPRKFGDDQRPP
RRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFEDRPP
RRFDDERPPRRSGDDQRPPRRFEDRPARAPRPERDERAPQREAAHTPGSAPLAESSGLVRLSKRMSELGLCSRREADEWI
PRGWVLVDGEPVTELGSRVRPDAEIEILPAARSEQGERVTVLLHKPVGYVSGQAEDGYEPAAALFTAENQWEEDPTRKHF
AAWQHKGLAPAGRLDIDSTGLLVLTQDGRVARHLIGEDSTVEKEYLVRVVWNAPQGPVEHDISKVFPEDLLEMLRHGLSL
DGEALKPAKVSWQNEEQLRFVLREGKKRQIRRMCEQVGLEVVGLKRIRMGSVVLGDLPVGKWRFLGRFEKF
>Mature_630_residues
TDSDDFPGDDTKRSASDPTQRATRPGKRATLGVRRDDTGNPVRTTGKPLRASDLNRDRQPLRPSQRRPKPQEGDAKRPAR
ARRDDDSQPPREAKPRRMQGDRPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRKF
GDDQRPPRRFGDEQPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFDDERPPRRFEDRPPRRFDDERPPRKFGDDQRPPR
RFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFEDRPPR
RFDDERPPRRSGDDQRPPRRFEDRPARAPRPERDERAPQREAAHTPGSAPLAESSGLVRLSKRMSELGLCSRREADEWIP
RGWVLVDGEPVTELGSRVRPDAEIEILPAARSEQGERVTVLLHKPVGYVSGQAEDGYEPAAALFTAENQWEEDPTRKHFA
AWQHKGLAPAGRLDIDSTGLLVLTQDGRVARHLIGEDSTVEKEYLVRVVWNAPQGPVEHDISKVFPEDLLEMLRHGLSLD
GEALKPAKVSWQNEEQLRFVLREGKKRQIRRMCEQVGLEVVGLKRIRMGSVVLGDLPVGKWRFLGRFEKF

Specific function: Responsible for synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4503509, Length=277, Percent_Identity=45.1263537906137, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1790453, Length=247, Percent_Identity=34.412955465587, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788510, Length=248, Percent_Identity=30.6451612903226, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787524, Length=264, Percent_Identity=31.8181818181818, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI87081838, Length=157, Percent_Identity=31.8471337579618, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980586, Length=328, Percent_Identity=20.4268292682927, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71980604, Length=328, Percent_Identity=20.4268292682927, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR006145
- InterPro:   IPR000748
- InterPro:   IPR018496
- InterPro:   IPR002942 [H]

Pfam domain/function: PF00849 PseudoU_synth_2; PF01479 S4 [H]

EC number: NA

Molecular weight: Translated: 74221; Mature: 74089

Theoretical pI: Translated: 11.06; Mature: 11.06

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSDDFPGDDTKRSASDPTQRATRPGKRATLGVRRDDTGNPVRTTGKPLRASDLNRDRQ
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCCC
PLRPSQRRPKPQEGDAKRPARARRDDDSQPPREAKPRRMQGDRPPRRFEDRPPRRFDDER
CCCCHHCCCCCCCCCCCCCHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPRKFGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFGDEQPPRRF
CCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHCCCCCCCCHH
EDRPPRRFDDERPPRKFGDDQRPPRRFDDERPPRRFEDRPPRRFDDERPPRKFGDDQRPP
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCH
RRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFGDERPPRRFEDRPPRRFDDER
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
PPRRSGDDQRPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFEDRPARAPRPERDERAPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHCCH
REAAHTPGSAPLAESSGLVRLSKRMSELGLCSRREADEWIPRGWVLVDGEPVTELGSRVR
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
PDAEIEILPAARSEQGERVTVLLHKPVGYVSGQAEDGYEPAAALFTAENQWEEDPTRKHF
CCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHEECCCCCCCCHHHHHH
AAWQHKGLAPAGRLDIDSTGLLVLTQDGRVARHLIGEDSTVEKEYLVRVVWNAPQGPVEH
HHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCHHH
DISKVFPEDLLEMLRHGLSLDGEALKPAKVSWQNEEQLRFVLREGKKRQIRRMCEQVGLE
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCE
VVGLKRIRMGSVVLGDLPVGKWRFLGRFEKF
EEHHHHHHCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDSDDFPGDDTKRSASDPTQRATRPGKRATLGVRRDDTGNPVRTTGKPLRASDLNRDRQ
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCCC
PLRPSQRRPKPQEGDAKRPARARRDDDSQPPREAKPRRMQGDRPPRRFEDRPPRRFDDER
CCCCHHCCCCCCCCCCCCCHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPRKFGDDQRPPRRFGDERPPRRFEDRPPRRFDDERPPRKFGDDQRPPRRFGDEQPPRRF
CCHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHCCCCCCCCHH
EDRPPRRFDDERPPRKFGDDQRPPRRFDDERPPRRFEDRPPRRFDDERPPRKFGDDQRPP
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCH
RRFGDERPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFGDERPPRRFEDRPPRRFDDER
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
PPRRSGDDQRPPRRFEDRPPRRFDDERPPRRSGDDQRPPRRFEDRPARAPRPERDERAPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHCCH
REAAHTPGSAPLAESSGLVRLSKRMSELGLCSRREADEWIPRGWVLVDGEPVTELGSRVR
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
PDAEIEILPAARSEQGERVTVLLHKPVGYVSGQAEDGYEPAAALFTAENQWEEDPTRKHF
CCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHEECCCCCCCCHHHHHH
AAWQHKGLAPAGRLDIDSTGLLVLTQDGRVARHLIGEDSTVEKEYLVRVVWNAPQGPVEH
HHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCHHH
DISKVFPEDLLEMLRHGLSLDGEALKPAKVSWQNEEQLRFVLREGKKRQIRRMCEQVGLE
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCE
VVGLKRIRMGSVVLGDLPVGKWRFLGRFEKF
EEHHHHHHCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]