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The map label for this gene is moaE

Identifier: 17546051

GI number: 17546051

Start: 1417586

End: 1418116

Strand: Direct

Name: moaE

Synonym: RSc1332

Alternate gene names: 17546051

Gene position: 1417586-1418116 (Clockwise)

Preceding gene: 17546050

Following gene: 17546052

Centisome position: 38.14

GC content: 67.98

Gene sequence:

>531_bases
ATGCCCACGATACGTGTACAGGAAGCGGATTTCGACCTGGGCGCCGAGATCGCCGCGCTGCGCGCGGGCCGGCCGCAGAT
CGGCGCGGTGGCGAGCTTCATCGGCACGGTGCGCGACATCAACGACGGCAGCGGCGTGTCCGAGATGGAGCTGGAGCACT
ATCCGGGCATGACGGAGAAGGCGCTGGCCAATATCGTCGATGCGGCGATGCAGCGCTGGGACCTGATCGATGCGCTGGTC
ATCCACCGGGTGGGCAAGCTCCGGCCCGAAGACCAGATCGTGCTGGTGGCGGTGGCGTCCGGCCATCGCGGCGAGGCCTT
TGCCGCCTGCGAATTCATCATGGACTACCTCAAGAGCGAGGCCCCGTTCTGGAAGAAGGAGCAGACGGCGCAGGGTGCCC
GCTGGGTCGACGCGCGCGTGACCGATGAACGGGCGCTGGCGCGCTGGGGCATCGTCACGGACAACGCCTCGGCTGCCACC
GCCCAGGCAGCCTCCGCCAACGACCAGAACCAGAAGGACCGCGACGCATGA

Upstream 100 bases:

>100_bases
GGCGCTGGACCACGATGTGGTCACCGCCGATGCGCCGCTGCGCGAGGGCTGCGAGGTCGCGTTCTTTCCGCCGGTGACGG
GCGGCTGAGGGGAGGCGCGC

Downstream 100 bases:

>100_bases
GCGGGATGGGGTTCGTGGCCGTGGGCGTGGGTGCCGCGCTGGGTGCATGGCTGCGCTGGGCATTCGCGGTGCTGTGGAAT
GCGATCAACCCCGCCTTGCC

Product: molybdopterin MPT converting factor subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MPTIRVQEADFDLGAEIAALRAGRPQIGAVASFIGTVRDINDGSGVSEMELEHYPGMTEKALANIVDAAMQRWDLIDALV
IHRVGKLRPEDQIVLVAVASGHRGEAFAACEFIMDYLKSEAPFWKKEQTAQGARWVDARVTDERALARWGIVTDNASAAT
AQAASANDQNQKDRDA

Sequences:

>Translated_176_residues
MPTIRVQEADFDLGAEIAALRAGRPQIGAVASFIGTVRDINDGSGVSEMELEHYPGMTEKALANIVDAAMQRWDLIDALV
IHRVGKLRPEDQIVLVAVASGHRGEAFAACEFIMDYLKSEAPFWKKEQTAQGARWVDARVTDERALARWGIVTDNASAAT
AQAASANDQNQKDRDA
>Mature_175_residues
PTIRVQEADFDLGAEIAALRAGRPQIGAVASFIGTVRDINDGSGVSEMELEHYPGMTEKALANIVDAAMQRWDLIDALVI
HRVGKLRPEDQIVLVAVASGHRGEAFAACEFIMDYLKSEAPFWKKEQTAQGARWVDARVTDERALARWGIVTDNASAATA
QAASANDQNQKDRDA

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=111, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1787003, Length=146, Percent_Identity=54.7945205479452, Blast_Score=156, Evalue=9e-40,
Organism=Drosophila melanogaster, GI21356259, Length=102, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_RALSO (Q8XZR3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519453.1
- ProteinModelPortal:   Q8XZR3
- SMR:   Q8XZR3
- GeneID:   1220156
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1332
- NMPDR:   fig|267608.1.peg.1332
- HOGENOM:   HBG460564
- OMA:   GAVACFV
- ProtClustDB:   CLSK2302527
- BioCyc:   RSOL267608:RSC1332-MONOMER
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 19151; Mature: 19019

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIRVQEADFDLGAEIAALRAGRPQIGAVASFIGTVRDINDGSGVSEMELEHYPGMTEK
CCCCEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHH
ALANIVDAAMQRWDLIDALVIHRVGKLRPEDQIVLVAVASGHRGEAFAACEFIMDYLKSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCC
APFWKKEQTAQGARWVDARVTDERALARWGIVTDNASAATAQAASANDQNQKDRDA
CCCCCCHHHCCCCEEECCCCCHHHHHHHCCCEECCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PTIRVQEADFDLGAEIAALRAGRPQIGAVASFIGTVRDINDGSGVSEMELEHYPGMTEK
CCCEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHH
ALANIVDAAMQRWDLIDALVIHRVGKLRPEDQIVLVAVASGHRGEAFAACEFIMDYLKSE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCC
APFWKKEQTAQGARWVDARVTDERALARWGIVTDNASAATAQAASANDQNQKDRDA
CCCCCCHHHCCCCEEECCCCCHHHHHHHCCCEECCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852