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The map label for this gene is lexA [H]

Identifier: 17546023

GI number: 17546023

Start: 1391233

End: 1391883

Strand: Reverse

Name: lexA [H]

Synonym: RSc1304

Alternate gene names: 17546023

Gene position: 1391883-1391233 (Counterclockwise)

Preceding gene: 17546033

Following gene: 17546022

Centisome position: 37.45

GC content: 66.82

Gene sequence:

>651_bases
ATGGCTACCCTCACCACTCGCCAGCAGCAGATCTACGACCTGATCCACCAAACGATCCAGCGCACCGGCTTCCCGCCGAC
GCGCGCCGAGATCGCCGCGGAGTTCGGCTTCTCGTCGCCGAATGCGGCCGAGGAGCACCTGCGGGCACTCGCCCGCAAGG
GCGTGATCGAGCTGACGCCCGGCGCATCACGCGGTATCCGGCTGCGCGCGGAGGGCGGCGCATCGCCGCACCAGTTCTCG
CTGCCGTCGATGGGGCTGATGCAGCTGACGCTGCCGCTGGTGGGCCGCGTTGCGGCGGGTAGCCCGATCCTGGCAGCCGA
GCACATCGACCGGCAATACCAGGTCGACCCTTCCCTGTTTTCCAGTCGGCCGGATTTCCTGTTGAAAGTGCGCGGCATGA
GCATGCGCGATGCCGGCATCCTCGACGGCGACCTGCTCGCGGTACAGCGCGCCGCCGAGGCCGCCAACGGCAAGATCGTC
GTTGCGCGGCTGGGCGATGATGTCACGGTTAAGCGCTTTCAGCGCAAAGGCCGGCAGGTCGAGCTGATTGCCGAGAACCC
TGATTTCGAACCCATCCACGTCGATCTCGACCGCGACGAGTTCCAGTTGGAAGGACTGGCGGTCGGCCTGATCCGGCCAG
CCGCTCCATAA

Upstream 100 bases:

>100_bases
GGTCGATGCGTCCGCTCAACAACAAGTCACAATAAAATCACTTGCGCTCTGCTTCTCACTGTATAAAATCACAGCACCTG
TTCAAATATACAGTGTACCG

Downstream 100 bases:

>100_bases
CCACTCGGCGCAGCGCGCCGCTTCCCTCGCAGTTTTGCCCAACCCGGAGGTGAGCCTATGGCTCGCCGCGGCGGACTGTT
GCCGTCCGCGCCTCCACCGA

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MATLTTRQQQIYDLIHQTIQRTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLRAEGGASPHQFS
LPSMGLMQLTLPLVGRVAAGSPILAAEHIDRQYQVDPSLFSSRPDFLLKVRGMSMRDAGILDGDLLAVQRAAEAANGKIV
VARLGDDVTVKRFQRKGRQVELIAENPDFEPIHVDLDRDEFQLEGLAVGLIRPAAP

Sequences:

>Translated_216_residues
MATLTTRQQQIYDLIHQTIQRTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLRAEGGASPHQFS
LPSMGLMQLTLPLVGRVAAGSPILAAEHIDRQYQVDPSLFSSRPDFLLKVRGMSMRDAGILDGDLLAVQRAAEAANGKIV
VARLGDDVTVKRFQRKGRQVELIAENPDFEPIHVDLDRDEFQLEGLAVGLIRPAAP
>Mature_215_residues
ATLTTRQQQIYDLIHQTIQRTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTPGASRGIRLRAEGGASPHQFSL
PSMGLMQLTLPLVGRVAAGSPILAAEHIDRQYQVDPSLFSSRPDFLLKVRGMSMRDAGILDGDLLAVQRAAEAANGKIVV
ARLGDDVTVKRFQRKGRQVELIAENPDFEPIHVDLDRDEFQLEGLAVGLIRPAAP

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=212, Percent_Identity=58.4905660377358, Blast_Score=244, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23536; Mature: 23405

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLTTRQQQIYDLIHQTIQRTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTP
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECC
GASRGIRLRAEGGASPHQFSLPSMGLMQLTLPLVGRVAAGSPILAAEHIDRQYQVDPSLF
CCCCCEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCCEECCHHHH
SSRPDFLLKVRGMSMRDAGILDGDLLAVQRAAEAANGKIVVARLGDDVTVKRFQRKGRQV
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEE
ELIAENPDFEPIHVDLDRDEFQLEGLAVGLIRPAAP
EEEECCCCCCEEEEECCCCCEEECEEEEEEECCCCC
>Mature Secondary Structure 
ATLTTRQQQIYDLIHQTIQRTGFPPTRAEIAAEFGFSSPNAAEEHLRALARKGVIELTP
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECC
GASRGIRLRAEGGASPHQFSLPSMGLMQLTLPLVGRVAAGSPILAAEHIDRQYQVDPSLF
CCCCCEEEEECCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCCEECCHHHH
SSRPDFLLKVRGMSMRDAGILDGDLLAVQRAAEAANGKIVVARLGDDVTVKRFQRKGRQV
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCEE
ELIAENPDFEPIHVDLDRDEFQLEGLAVGLIRPAAP
EEEECCCCCCEEEEECCCCCEEECEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA