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The map label for this gene is cobB

Identifier: 17545949

GI number: 17545949

Start: 1301591

End: 1302331

Strand: Direct

Name: cobB

Synonym: RSc1230

Alternate gene names: 17545949

Gene position: 1301591-1302331 (Clockwise)

Preceding gene: 17545948

Following gene: 17545951

Centisome position: 35.02

GC content: 71.79

Gene sequence:

>741_bases
TTGCCCACGGCTGTCTCCGACGCGGCGGCCCCGGCTCAGGCGCGTGCCTGGATCGAGGCGGCCGAGCGCGTCATGGTGCT
GACCGGCGCCGGCGTGTCGGCCGAATCCGGCGTGCCGACCTTCCGCGATGCGCTGACCGGCCTGTGGGCCCGCTTCAACC
CAGAGGACCTGGCGACCGAAGCCGCGTATCGCGAGCATCCGCGCATGGTGTGGGATTGGTACCAGGAGCGCCGCGCGCGC
GTGTCGCAGGTGCAGCCGAACCCGGCGCATCTGGCGATTGCCGCGCTGGCCACGCGCAAGACGGTGGCGCTCGTTACGCA
GAATGTCGATGGCCTGCACCAGCGGGCCGGCAGCGTGGGTGTGATCGAGCTGCACGGCAACCTCTTCGCCAACAAATGGC
TGGACGGCTGCGGCAAGTGTGATGTCGCCACGGCCGAGCCCGGCCGGCCGCCGCGCTGCGCGGCCTGCGGTGCGATGCTG
CGTCCGGGCGTGGTGTGGTTCGGCGAGCGGCTGCCCGTGGTGGCGAACTACCGCGCGGAAGAGGCGGCCAACACGTGCGA
CGTGTGCCTGGTGGTGGGCACCTCGGGCATGGTGTATCCGGCGGCCGGACTGCCGGGGCTGGCGAAGGACCACGGCGCGC
GCGTCATCGTGGTGAATCCGGAGCCGAGCGTGCTGGACGAGACCGCCGATCTCGTCATCCACCAGCCGGCGGGCGTATGC
CTGCCCGCCATGCTGGCGTAG

Upstream 100 bases:

>100_bases
CGGGCAGTGTGGAGAGCCTGAACGTCTCGGTGGCCAGCGGTGTGTGCCTGTTCGAGGCGGTGCGCCAGCGCAGCGTCGTG
CCTGCCAAGTGATGGACGTA

Downstream 100 bases:

>100_bases
TGCTTCACGCCGGCTTCACGCGGCCGCGCGCAGCGGCCCGATCAGACCTTCCAGCTTGACCGCATCCGCCGCGAACAGGC
GGATGCCTTCGGCCAGCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MPTAVSDAAAPAQARAWIEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRAR
VSQVQPNPAHLAIAALATRKTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDGCGKCDVATAEPGRPPRCAACGAML
RPGVVWFGERLPVVANYRAEEAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVC
LPAMLA

Sequences:

>Translated_246_residues
MPTAVSDAAAPAQARAWIEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRAR
VSQVQPNPAHLAIAALATRKTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDGCGKCDVATAEPGRPPRCAACGAML
RPGVVWFGERLPVVANYRAEEAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVC
LPAMLA
>Mature_245_residues
PTAVSDAAAPAQARAWIEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRARV
SQVQPNPAHLAIAALATRKTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDGCGKCDVATAEPGRPPRCAACGAMLR
PGVVWFGERLPVVANYRAEEAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVCL
PAMLA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=255, Percent_Identity=39.2156862745098, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6912664, Length=272, Percent_Identity=37.5, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI13787215, Length=247, Percent_Identity=38.8663967611336, Blast_Score=154, Evalue=7e-38,
Organism=Homo sapiens, GI6912662, Length=273, Percent_Identity=29.3040293040293, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI300797597, Length=214, Percent_Identity=33.1775700934579, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI300797577, Length=232, Percent_Identity=31.4655172413793, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI6912660, Length=226, Percent_Identity=29.2035398230088, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI13775602, Length=214, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI13775600, Length=221, Percent_Identity=26.6968325791855, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI7657575, Length=224, Percent_Identity=30.8035714285714, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI63054862, Length=203, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI300797705, Length=199, Percent_Identity=26.6331658291457, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI308199517, Length=228, Percent_Identity=41.2280701754386, Blast_Score=147, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71990482, Length=270, Percent_Identity=27.4074074074074, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17567771, Length=278, Percent_Identity=25.8992805755396, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71990487, Length=272, Percent_Identity=27.2058823529412, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17541892, Length=232, Percent_Identity=29.3103448275862, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571445, Length=268, Percent_Identity=29.4776119402985, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648389, Length=223, Percent_Identity=28.2511210762332, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137536, Length=229, Percent_Identity=27.9475982532751, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_RALSO (Q8Y015)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519351.1
- ProteinModelPortal:   Q8Y015
- SMR:   Q8Y015
- GeneID:   1220053
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1230
- NMPDR:   fig|267608.1.peg.1230
- HOGENOM:   HBG641281
- OMA:   DADGLWE
- ProtClustDB:   CLSK896884
- BioCyc:   RSOL267608:RSC1230-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26062; Mature: 25931

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAVSDAAAPAQARAWIEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATE
CCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
AAYREHPRMVWDWYQERRARVSQVQPNPAHLAIAALATRKTVALVTQNVDGLHQRAGSVG
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHEEEEEECCCHHHHHHCCCEE
VIELHGNLFANKWLDGCGKCDVATAEPGRPPRCAACGAMLRPGVVWFGERLPVVANYRAE
EEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCHH
EAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVC
HCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHCCCCEEEECCCCCC
LPAMLA
HHHHCC
>Mature Secondary Structure 
PTAVSDAAAPAQARAWIEAAERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATE
CCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
AAYREHPRMVWDWYQERRARVSQVQPNPAHLAIAALATRKTVALVTQNVDGLHQRAGSVG
HHHHHCCCHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHEEEEEECCCHHHHHHCCCEE
VIELHGNLFANKWLDGCGKCDVATAEPGRPPRCAACGAMLRPGVVWFGERLPVVANYRAE
EEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCHH
EAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVC
HCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHCCCCEEEECCCCCC
LPAMLA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852