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The map label for this gene is hisZ [H]

Identifier: 17545944

GI number: 17545944

Start: 1294406

End: 1295566

Strand: Direct

Name: hisZ [H]

Synonym: RSc1225

Alternate gene names: 17545944

Gene position: 1294406-1295566 (Clockwise)

Preceding gene: 17545943

Following gene: 17545945

Centisome position: 34.83

GC content: 70.89

Gene sequence:

>1161_bases
ATGCCGAACTGGCTGCTGCCTGAATCCATTGCCGACGTGCTGCCTTCCGAGGCGCGCAAGATCGAGGAGCTGCGCCGCCG
CATGCTCGACCTGTTCCGCACCTACGGCTATGAGCTGGTGATGCCGCCGATGCTGGAGTACATCGAGTCGCTGCTGTCCG
GCACCGGCCACGATCTGGATCTGAAGACCTTCAAGCTGGTCGATCAGTTGTCCGGCCGCACGATCGGCCTGCGCGCCGAT
ATCACGCCGCAGGTTGCCCGCATCGACGCCCACCTGCTGAACCGTGCCGGCGTGACGCGCCTGTGCTACGCCGGCTCGGT
GCTGCATACGCGGCCGAGCGGCTTCCACGTCACGCGCGAGCCGCTGCAGATCGGTGCCGAGATCTACGGCCACGCGGGCC
TCGAGGCCGACCTGGAGATCCAGGACCTGATGCTGGCCGCGCTGTCGGCCGCCGGCCTGGCGGATGTGCGGCTGGACCTG
TGCCACGTCGGCGTGCTCGCCGCGCTGCTGGCGCAGGCGCCCGTGGCGCCGGACGTCCAGGACGAACTCTTCGCCGCGCT
GGCCTCCAAGGATGCGCCGGCGCTGCATGCACTCACCGCCGGGCTGCCGGCCGCGCAGCGCGACGCCATCAATCTGCTGC
CGTCGCTGTACGGCGGCGTCGACGTGCTGGCCCGGGCCCGGGCGCAGTTGCCGCAGCTGCCGGCGATCGGCCGCGCGCTG
GATGACCTGGCCACGCTGGCCGCGCATGCCGGCGGGGCGGCCGTCAATATCGATCTGGCCGACCTGCGCGGCTACCACTA
CCACAGCGGCGTCATGTTCGCGGCGTATGTCGCGGGCGTGCCCAACGCGGTCGCGCGTGGCGGCCGCTACGACAAGGTCG
GCGAGGCGTTCGGCCGGGCTCGTCCGGCGACAGGCTTTTCGCTGGATTTGCGCGAGGTTGCGGGCATTTCGCCGGTGCAG
GCGCGTGCTGCCGCCATTCATGCGCCGTGGTCGGGGGATGCGAAGCTGCGCGAGGCGATCGCCGGCCTGCGCGCCACCGG
AGAGATCGTGATCCAGTCGCTGCCGGGGCACCCGGAAGACCTGGAGGAATTCGCCTACGACCGCCAGTTGGCGGAGGAGG
GCGGGCGCTGGGTCGTCAAGCCGCGCAAGGCGTCGGCCTGA

Upstream 100 bases:

>100_bases
GTGTCGATGGCCGTGGGGCTGATCCTGCTGCGCCTGCTGCACCGCTGATCCGCCGTCAGCACACGACTGTTTTCGTATTC
CCGTATTGAGCGAGACCGCC

Downstream 100 bases:

>100_bases
GGCTGTTACACGAACGCAGTATGAGCCTCCGCTCGTTTCGGGGACCGCCCTGACAACGAGGGTAGAATACGTTTTTAACC
CATCAGTAAATTCAACATGT

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLDLKTFKLVDQLSGRTIGLRAD
ITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTREPLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDL
CHVGVLAALLAQAPVAPDVQDELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRAL
DDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRARPATGFSLDLREVAGISPVQ
ARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPEDLEEFAYDRQLAEEGGRWVVKPRKASA

Sequences:

>Translated_386_residues
MPNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLDLKTFKLVDQLSGRTIGLRAD
ITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTREPLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDL
CHVGVLAALLAQAPVAPDVQDELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRAL
DDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRARPATGFSLDLREVAGISPVQ
ARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPEDLEEFAYDRQLAEEGGRWVVKPRKASA
>Mature_385_residues
PNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLDLKTFKLVDQLSGRTIGLRADI
TPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTREPLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDLC
HVGVLAALLAQAPVAPDVQDELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRALD
DLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRARPATGFSLDLREVAGISPVQA
RAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPEDLEEFAYDRQLAEEGGRWVVKPRKASA

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004517
- InterPro:   IPR004516 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 41185; Mature: 41053

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLD
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCCCCC
LKTFKLVDQLSGRTIGLRADITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTRE
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCHHEECCCCCCEEHH
PLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDLCHVGVLAALLAQAPVAPDVQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRAL
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRA
HHHHHHHHHCCCCEEEEEHHHCCCCEECCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCC
RPATGFSLDLREVAGISPVQARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPED
CCCCCCCCCHHHHCCCCHHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHEECCCCCHHH
LEEFAYDRQLAEEGGRWVVKPRKASA
HHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
PNWLLPESIADVLPSEARKIEELRRRMLDLFRTYGYELVMPPMLEYIESLLSGTGHDLD
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCCCCC
LKTFKLVDQLSGRTIGLRADITPQVARIDAHLLNRAGVTRLCYAGSVLHTRPSGFHVTRE
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCHHEECCCCCCEEHH
PLQIGAEIYGHAGLEADLEIQDLMLAALSAAGLADVRLDLCHVGVLAALLAQAPVAPDVQ
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DELFAALASKDAPALHALTAGLPAAQRDAINLLPSLYGGVDVLARARAQLPQLPAIGRAL
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DDLATLAAHAGGAAVNIDLADLRGYHYHSGVMFAAYVAGVPNAVARGGRYDKVGEAFGRA
HHHHHHHHHCCCCEEEEEHHHCCCCEECCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCC
RPATGFSLDLREVAGISPVQARAAAIHAPWSGDAKLREAIAGLRATGEIVIQSLPGHPED
CCCCCCCCCHHHHCCCCHHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHEECCCCCHHH
LEEFAYDRQLAEEGGRWVVKPRKASA
HHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA