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The map label for this gene is degU [H]

Identifier: 17545904

GI number: 17545904

Start: 1247779

End: 1248447

Strand: Reverse

Name: degU [H]

Synonym: RSc1185

Alternate gene names: 17545904

Gene position: 1248447-1247779 (Counterclockwise)

Preceding gene: 17545905

Following gene: 17545903

Centisome position: 33.59

GC content: 65.62

Gene sequence:

>669_bases
ATGAACACTGTTTTGATCGAAGCGCATCCGCTGGTGCGCACGGGCATTGCGCACCTGTTGCGCACACTCAAGGGCGTCAC
CGGCGTCACCGTCGTTGAACCGGACGAGGGCATGTTCGATGCCATCGAAGCCCACGCGGACGCCGGACTCCTGGTCATCG
GACTGCCGCTGCCACATCTGGACGAACTGTCCGCCATCGGCGAAATCATGCACCGGCCGCACGCCCGCCACGTGGTGGTG
CTGGCCGAATCGGAGTCGCCGGACATCATCCGCACCCTCATGCAGATGGGGCTGTCGGGCTACACGCTCAAGCATTCGCC
CGGCGAGGTCATCGCGGCATCGCTGGAGCTCGTTCTGGTCGGCGGACAGTACATCCCCGCCAGCGCGCTGCTGCCCGAAT
CGCGGCTGGACGGTACGCCCAACCCCTCGCTGGCCGGCGATCCGCAGACCGATCCCAAGTTGCTCGGGATCACCCCGCGC
CAATACGAAATCCTGGTGCTGCTCTCACGCGGACACCCGGTCAAGACCATCAGCCGCATGCTGAACATCTCCGAGGCCAC
CGCCAAGGCGCATATCAGCACACTGTATCGCCGGCTGAAGGTACGCAGCCGGACCGAGGCCGTCTACGTCGCCAACCAGC
GCGGCGCGCGGCTGCTATCGGTGGCCTGA

Upstream 100 bases:

>100_bases
ACGCCACTAAAATGGTTCGGAACGGGGGTCTGCTCCGGCCGATATCTCGCCTGGGGCGACAGAGGATGTTCGCAAGATCG
GTCACAGGTCGAGAACAACG

Downstream 100 bases:

>100_bases
CGCCGGCCGCCTGAACACCGAGGTGAAGGCTGGGACGCGCACCCTATACTGGGCGCATGCTTTCAAGACTCTCCCAATGG
CTGTCGCGACGCGCACGCTC

Product: transcription regulator protein

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNTVLIEAHPLVRTGIAHLLRTLKGVTGVTVVEPDEGMFDAIEAHADAGLLVIGLPLPHLDELSAIGEIMHRPHARHVVV
LAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASLELVLVGGQYIPASALLPESRLDGTPNPSLAGDPQTDPKLLGITPR
QYEILVLLSRGHPVKTISRMLNISEATAKAHISTLYRRLKVRSRTEAVYVANQRGARLLSVA

Sequences:

>Translated_222_residues
MNTVLIEAHPLVRTGIAHLLRTLKGVTGVTVVEPDEGMFDAIEAHADAGLLVIGLPLPHLDELSAIGEIMHRPHARHVVV
LAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASLELVLVGGQYIPASALLPESRLDGTPNPSLAGDPQTDPKLLGITPR
QYEILVLLSRGHPVKTISRMLNISEATAKAHISTLYRRLKVRSRTEAVYVANQRGARLLSVA
>Mature_222_residues
MNTVLIEAHPLVRTGIAHLLRTLKGVTGVTVVEPDEGMFDAIEAHADAGLLVIGLPLPHLDELSAIGEIMHRPHARHVVV
LAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASLELVLVGGQYIPASALLPESRLDGTPNPSLAGDPQTDPKLLGITPR
QYEILVLLSRGHPVKTISRMLNISEATAKAHISTLYRRLKVRSRTEAVYVANQRGARLLSVA

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=220, Percent_Identity=28.6363636363636, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787473, Length=213, Percent_Identity=28.169014084507, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789937, Length=74, Percent_Identity=45.945945945946, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=24.8847926267281, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23920; Mature: 23920

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVLIEAHPLVRTGIAHLLRTLKGVTGVTVVEPDEGMFDAIEAHADAGLLVIGLPLPHL
CCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCH
DELSAIGEIMHRPHARHVVVLAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASLELVLV
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCHHEEEEEEEEEE
GGQYIPASALLPESRLDGTPNPSLAGDPQTDPKLLGITPRQYEILVLLSRGHPVKTISRM
CCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHH
LNISEATAKAHISTLYRRLKVRSRTEAVYVANQRGARLLSVA
HCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECC
>Mature Secondary Structure
MNTVLIEAHPLVRTGIAHLLRTLKGVTGVTVVEPDEGMFDAIEAHADAGLLVIGLPLPHL
CCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCCEEEEECCCCCH
DELSAIGEIMHRPHARHVVVLAESESPDIIRTLMQMGLSGYTLKHSPGEVIAASLELVLV
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCHHEEEEEEEEEE
GGQYIPASALLPESRLDGTPNPSLAGDPQTDPKLLGITPRQYEILVLLSRGHPVKTISRM
CCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHH
LNISEATAKAHISTLYRRLKVRSRTEAVYVANQRGARLLSVA
HCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]