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The map label for this gene is ltaA [H]

Identifier: 17545527

GI number: 17545527

Start: 855098

End: 856135

Strand: Direct

Name: ltaA [H]

Synonym: RSc0808

Alternate gene names: 17545527

Gene position: 855098-856135 (Clockwise)

Preceding gene: 17545526

Following gene: 17545528

Centisome position: 23.01

GC content: 68.79

Gene sequence:

>1038_bases
ATGCAACACTTCGCCTCCGACAACTACGCCGGCTTCTGCCCGGAATCCCTGAAGTACTTCCTGGAAGCGAACGGCAGCGG
CCACGAGCCCGCCTACGGCGACGACTCCTGGACGCAGCGCGTATGCGACCGCATCCGCGATCTGTTCGAGACCGATTGCG
AAGTCTTTTTCGTCTTCAACGGCACCGCCGCCAATTCGCTGGCGCTGTCCGCGCTGTGCCAGTCGTACCACTCCGTCATC
TGCCATGAGCTGGCGCACATCGAGACGGACGAGTGCGGCGGCCCCGAGTTCTTCTCCAACGGCTCCAAGCTGCTGACCGC
CGAGGGCGCCGACGGCAAGCTGACGCCCGACGCGGTGGAGGCGCTGGTCACGCGCCGCTCCGACATCCACTACCCCAAGC
CCAAGGTGGTCTCGCTCACGCAGTCGACCGAGGTGGGCACGGTCTACACGGTGGACGAGGTGCGGGCGATTGCCGCTGTC
GCCCGCCGCCGGCAGCTGCGCGTGCACATGGACGGCGCGCGCTTCGCCAACGCGGTGGCCTCGCTCGGCGTGCATCCGTC
CGAGATCACCTGGCGCGCGGGGGTGGACGTGCTGTGCTTCGGCGGCACCAAGAATGGCCTGCCGGTGGGCGAGGCGGTGG
TGTTCTTCAACCGCCGCCTGGCCGAGGACTTCGCCTACCGCGTCAAGCAGGCCGGGCAACTGGCCTCCAAGATGCGCTTC
ATCTCCGCGCCGTGGCTGGGCCTGCTGGAGAACGACGTGTGGCTGCGCAACGCGCGCCATGCCAACGCGATGGCGCAACT
GCTGCACCAGCGCATCCGCGAGGTGCCGGGCGTGCGCATCATGTTCCCGCCGCAGGCCAATGCCGTGTTCGCCGAGCTGC
CGCTGCCCGCCATCGAGACGCTGCGCGCGCGCGGCTGGCGCTTCTACACCTTCATCGGCGCAGGCGGCTGCCGCTTCATG
TGTGCGTGGGACTTGCAGCCCGAGACGGTGGAGGCGCTCGCCGGCGACATCCGCCTGGCCTGCGGACAGGCCGCATAG

Upstream 100 bases:

>100_bases
CGCGAGAACTGGGCCACCGGCGGCGTGCTCTGGTCCGAGCAGAAGTAAGCGCAAGACGATCTTCCCGCCCTCCCGCCTGG
CTCCGCCAACCCGACCCGCC

Downstream 100 bases:

>100_bases
CCCCGGGCACGACACGCCATGGGCTTCGATTACCGTTTCTGCCCGCAATGCGCGGCGCCGCTCGTCGAGCAGCATGCCGG
CGGCCGGCTGCGCATCGCGT

Product: low specificity L-threonine aldolase

Products: NA

Alternate protein names: Low specificity L-TA [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQHFASDNYAGFCPESLKYFLEANGSGHEPAYGDDSWTQRVCDRIRDLFETDCEVFFVFNGTAANSLALSALCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAEGADGKLTPDAVEALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVDEVRAIAAV
ARRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFNRRLAEDFAYRVKQAGQLASKMRF
ISAPWLGLLENDVWLRNARHANAMAQLLHQRIREVPGVRIMFPPQANAVFAELPLPAIETLRARGWRFYTFIGAGGCRFM
CAWDLQPETVEALAGDIRLACGQAA

Sequences:

>Translated_345_residues
MQHFASDNYAGFCPESLKYFLEANGSGHEPAYGDDSWTQRVCDRIRDLFETDCEVFFVFNGTAANSLALSALCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAEGADGKLTPDAVEALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVDEVRAIAAV
ARRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFNRRLAEDFAYRVKQAGQLASKMRF
ISAPWLGLLENDVWLRNARHANAMAQLLHQRIREVPGVRIMFPPQANAVFAELPLPAIETLRARGWRFYTFIGAGGCRFM
CAWDLQPETVEALAGDIRLACGQAA
>Mature_345_residues
MQHFASDNYAGFCPESLKYFLEANGSGHEPAYGDDSWTQRVCDRIRDLFETDCEVFFVFNGTAANSLALSALCQSYHSVI
CHELAHIETDECGGPEFFSNGSKLLTAEGADGKLTPDAVEALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVDEVRAIAAV
ARRRQLRVHMDGARFANAVASLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFNRRLAEDFAYRVKQAGQLASKMRF
ISAPWLGLLENDVWLRNARHANAMAQLLHQRIREVPGVRIMFPPQANAVFAELPLPAIETLRARGWRFYTFIGAGGCRFM
CAWDLQPETVEALAGDIRLACGQAA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. Can also act on L-erythro- phenylserine, L-threo-phenylserine, L-beta-3,4- methylenedioxyphenylserine and L-beta-3,4-dihydroxyphenylserine [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=244, Percent_Identity=28.6885245901639, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193206522, Length=188, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193206520, Length=188, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193206524, Length=188, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320789, Length=343, Percent_Identity=23.9067055393586, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 38017; Mature: 38017

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHFASDNYAGFCPESLKYFLEANGSGHEPAYGDDSWTQRVCDRIRDLFETDCEVFFVFN
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GTAANSLALSALCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAEGADGKLTPDAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCCHHHHH
ALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVDEVRAIAAVARRRQLRVHMDGARFANAVA
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHEEEEECHHHHHHHHH
SLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFNRRLAEDFAYRVKQAGQLASKMRF
HCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAPWLGLLENDVWLRNARHANAMAQLLHQRIREVPGVRIMFPPQANAVFAELPLPAIET
HCCCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCHHHHH
LRARGWRFYTFIGAGGCRFMCAWDLQPETVEALAGDIRLACGQAA
HHHCCEEEEEEEECCCEEEEEEECCCHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MQHFASDNYAGFCPESLKYFLEANGSGHEPAYGDDSWTQRVCDRIRDLFETDCEVFFVFN
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
GTAANSLALSALCQSYHSVICHELAHIETDECGGPEFFSNGSKLLTAEGADGKLTPDAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCCHHHHH
ALVTRRSDIHYPKPKVVSLTQSTEVGTVYTVDEVRAIAAVARRRQLRVHMDGARFANAVA
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHEEEEECHHHHHHHHH
SLGVHPSEITWRAGVDVLCFGGTKNGLPVGEAVVFFNRRLAEDFAYRVKQAGQLASKMRF
HCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAPWLGLLENDVWLRNARHANAMAQLLHQRIREVPGVRIMFPPQANAVFAELPLPAIET
HCCCCHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCHHHHH
LRARGWRFYTFIGAGGCRFMCAWDLQPETVEALAGDIRLACGQAA
HHHCCEEEEEEEECCCEEEEEEECCCHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9464392 [H]