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The map label for this gene is msrA

Identifier: 17545483

GI number: 17545483

Start: 806350

End: 806925

Strand: Direct

Name: msrA

Synonym: RSc0764

Alternate gene names: 17545483

Gene position: 806350-806925 (Clockwise)

Preceding gene: 17545481

Following gene: 17545487

Centisome position: 21.7

GC content: 66.15

Gene sequence:

>576_bases
ATGCAGGAGAGCACGATGACCGAACGACAAGCCCTTGAAACCGCCGTCCTGGGCGGGGGATGTTTCTGGTGCACGGAAGC
GGTGTTTCAGCAGGTGCAGGGCGTGCACAGTGTGGTGTCCGGCTATGCGGGCGGCCACCTCGAGCGGCCCACCTACCGCG
CCGTCTGCGGCGGTGACACCGGCCATGCCGAGGTGGTCAGGGTGGAATTCGACCCCGCGGTGATCCCGTACCGCGAGATT
CTCGACATCTTCTTCGCCACCCACGATCCGACCACGCTGGAGCGCCAGGGCAACGACATCGGTCCGCAGTACCGCTCGGC
CGTCTTCGCGCAGTCTCCCGAGCAGTTCGCGGAAGCCGGCGCCACCATCCGGGCACTGTCGGCCGCCAACGTCTTCGATG
CGCCCATCGTGACCGAGGTGGTGGACGCGAGCGGCGGCAAGGTGCCGTTCTGGCAAGCGGAAGACGAGCACCAGAATTAC
TTCCGCGACCACCCGGCGCAGGGCTATTGCGCATTCGTCATCTCGCCCAAGGTGGCGAAGTTCCGCGAACGGTTCGCACA
CCGCTTGCAGGCGTGA

Upstream 100 bases:

>100_bases
GACCGGTCTGCCCATGGGGCGATTGGGCTTTGCGTGATGCGGCGTCGACATGTCAGGATAGGGGGCCGGCCACGACCAAT
GGCGTTCCCTTTCGCAAGAC

Downstream 100 bases:

>100_bases
GCCGCAGGGTGGACCGCCAGCGTCGGGGTTAGGGCGTGTCGGCGGGCAGCCGCGCGGTGATGGCCTCGGCCAGCCGGATG
CACGACAGCGGCGAGCAGCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MQESTMTERQALETAVLGGGCFWCTEAVFQQVQGVHSVVSGYAGGHLERPTYRAVCGGDTGHAEVVRVEFDPAVIPYREI
LDIFFATHDPTTLERQGNDIGPQYRSAVFAQSPEQFAEAGATIRALSAANVFDAPIVTEVVDASGGKVPFWQAEDEHQNY
FRDHPAQGYCAFVISPKVAKFRERFAHRLQA

Sequences:

>Translated_191_residues
MQESTMTERQALETAVLGGGCFWCTEAVFQQVQGVHSVVSGYAGGHLERPTYRAVCGGDTGHAEVVRVEFDPAVIPYREI
LDIFFATHDPTTLERQGNDIGPQYRSAVFAQSPEQFAEAGATIRALSAANVFDAPIVTEVVDASGGKVPFWQAEDEHQNY
FRDHPAQGYCAFVISPKVAKFRERFAHRLQA
>Mature_191_residues
MQESTMTERQALETAVLGGGCFWCTEAVFQQVQGVHSVVSGYAGGHLERPTYRAVCGGDTGHAEVVRVEFDPAVIPYREI
LDIFFATHDPTTLERQGNDIGPQYRSAVFAQSPEQFAEAGATIRALSAANVFDAPIVTEVVDASGGKVPFWQAEDEHQNY
FRDHPAQGYCAFVISPKVAKFRERFAHRLQA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=167, Percent_Identity=40.7185628742515, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI208609995, Length=167, Percent_Identity=40.7185628742515, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI208609993, Length=118, Percent_Identity=39.8305084745763, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=47.1337579617834, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=36.4197530864198, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=32.3529411764706, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45553131, Length=164, Percent_Identity=31.7073170731707, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=31.1764705882353, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_RALSO (Q8Y1C6)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518885.1
- ProteinModelPortal:   Q8Y1C6
- SMR:   Q8Y1C6
- GeneID:   1219571
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0764
- NMPDR:   fig|267608.1.peg.764
- HOGENOM:   HBG748152
- OMA:   QGYCMAV
- ProtClustDB:   PRK14054
- BioCyc:   RSOL267608:RSC0764-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 21024; Mature: 21024

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: ACT_SITE 21-21

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESTMTERQALETAVLGGGCFWCTEAVFQQVQGVHSVVSGYAGGHLERPTYRAVCGGDT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GHAEVVRVEFDPAVIPYREILDIFFATHDPTTLERQGNDIGPQYRSAVFAQSPEQFAEAG
CCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHCC
ATIRALSAANVFDAPIVTEVVDASGGKVPFWQAEDEHQNYFRDHPAQGYCAFVISPKVAK
CCEEEHHHCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHH
FRERFAHRLQA
HHHHHHHHHCC
>Mature Secondary Structure
MQESTMTERQALETAVLGGGCFWCTEAVFQQVQGVHSVVSGYAGGHLERPTYRAVCGGDT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GHAEVVRVEFDPAVIPYREILDIFFATHDPTTLERQGNDIGPQYRSAVFAQSPEQFAEAG
CCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHCC
ATIRALSAANVFDAPIVTEVVDASGGKVPFWQAEDEHQNYFRDHPAQGYCAFVISPKVAK
CCEEEHHHCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHH
FRERFAHRLQA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852