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The map label for this gene is dapA2 [H]

Identifier: 17545384

GI number: 17545384

Start: 709993

End: 710907

Strand: Direct

Name: dapA2 [H]

Synonym: RSc0665

Alternate gene names: 17545384

Gene position: 709993-710907 (Clockwise)

Preceding gene: 17545366

Following gene: 17545386

Centisome position: 19.1

GC content: 71.26

Gene sequence:

>915_bases
ATGCTTGAACACCCTTCCGCAACCCTGCCTGCGCCATCCCGGGGGCGGCCTTCCTACGCCGGCATCTGGGTGCCCATCGT
CACCCCGTTTCTCGACGATGCGGCGCGCTCGGTCGACTATGGTGCGCTGTATGCCCTGGTGTCGCGCTACCGCACCGAGG
GCATCGCCGGTTTCGTCGCCTGCGGCAGCACCGGCGAAGCCGCGGCGCTGACCGACCAGGAGCAGGCCGATGTGCTCGAC
ACGGTACGTGCTGCGGCGGATGGCCTGCCGGTGGTGATGGGGCTGTCGGGCAGCGCGCTGGCGCCGGTGCGCGAGCGCAT
GTTGCGGCTCGCCGGGCACCATCCGGCGGCCTTCCTGGTGTCCCCGCCGTCGTATGTCCGGCCGTCCCAGGCGGGCCTGC
TGGAGTATTTCGCGGTGCTGGCCGATGCCTCGTCCGTGCCGCTGCTGTTGTACGACATTCCCTATCGCACCGGCGCGACC
CTGGCGACCGAGACCCTGCTGACCCTCGCCGGGCACGCTGGCATCCACGGCATCAAGGACTGCGGCGGCGACGCCGACAA
GACCCAGCGCCTGATCGCCGATGGCCGCCTGCAAGTGCTGGCCGGCGAGGACGCGCAGGTGTTCGGCACGCTGTGCCTGG
GCGGGGTCGGCGCGATCATCGCCTCCGCGCATGTGCGCACCGCATTGTTCGTGGAGATGGCGCGGGCGATCCGCGAACAG
CGCCTGGACGACGCGCGGCGCTTGCATCATGCGCTGGCGCCGGTGATCCGCCTGCTGTTCGCCGCGACCAATCCGGGGCC
GCTGAAGGCCTGGCTGGCGGCGCAGGGGCTGGTGCGGAATGTGTTGCGGGCGCCGATGACGGTGGCGCCCGAGGGCTTGC
AGGCGGCGCTGGCGGAGGCTGTCGCGTCGGTTTGA

Upstream 100 bases:

>100_bases
ACGGAACAGCGGCCAGCCGGCACGGTTGACCTCTTCCCCGGTACAGCGGGGCCACCCTCCTGACGGTTCTTGATCGGTCG
TGATTCGTCCAGGAGTCGTC

Downstream 100 bases:

>100_bases
GTGCTTGGGGGCCGGGACAGGCCTTGTTCCGGTGCCGTGTCCCGGCGTTCCGTCTCCTGCCGGGACCGGAACACGGGACG
GCCCCCCAACACCCCAAAAA

Product: dihydrodipicolinate synthase-like transmembrane protein

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLEHPSATLPAPSRGRPSYAGIWVPIVTPFLDDAARSVDYGALYALVSRYRTEGIAGFVACGSTGEAAALTDQEQADVLD
TVRAAADGLPVVMGLSGSALAPVRERMLRLAGHHPAAFLVSPPSYVRPSQAGLLEYFAVLADASSVPLLLYDIPYRTGAT
LATETLLTLAGHAGIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCLGGVGAIIASAHVRTALFVEMARAIREQ
RLDDARRLHHALAPVIRLLFAATNPGPLKAWLAAQGLVRNVLRAPMTVAPEGLQAALAEAVASV

Sequences:

>Translated_304_residues
MLEHPSATLPAPSRGRPSYAGIWVPIVTPFLDDAARSVDYGALYALVSRYRTEGIAGFVACGSTGEAAALTDQEQADVLD
TVRAAADGLPVVMGLSGSALAPVRERMLRLAGHHPAAFLVSPPSYVRPSQAGLLEYFAVLADASSVPLLLYDIPYRTGAT
LATETLLTLAGHAGIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCLGGVGAIIASAHVRTALFVEMARAIREQ
RLDDARRLHHALAPVIRLLFAATNPGPLKAWLAAQGLVRNVLRAPMTVAPEGLQAALAEAVASV
>Mature_304_residues
MLEHPSATLPAPSRGRPSYAGIWVPIVTPFLDDAARSVDYGALYALVSRYRTEGIAGFVACGSTGEAAALTDQEQADVLD
TVRAAADGLPVVMGLSGSALAPVRERMLRLAGHHPAAFLVSPPSYVRPSQAGLLEYFAVLADASSVPLLLYDIPYRTGAT
LATETLLTLAGHAGIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCLGGVGAIIASAHVRTALFVEMARAIREQ
RLDDARRLHHALAPVIRLLFAATNPGPLKAWLAAQGLVRNVLRAPMTVAPEGLQAALAEAVASV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=240, Percent_Identity=34.5833333333333, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786463, Length=248, Percent_Identity=31.0483870967742, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082415, Length=246, Percent_Identity=27.2357723577236, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789620, Length=275, Percent_Identity=24.3636363636364, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31779; Mature: 31779

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHPSATLPAPSRGRPSYAGIWVPIVTPFLDDAARSVDYGALYALVSRYRTEGIAGFVA
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
CGSTGEAAALTDQEQADVLDTVRAAADGLPVVMGLSGSALAPVRERMLRLAGHHPAAFLV
ECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEE
SPPSYVRPSQAGLLEYFAVLADASSVPLLLYDIPYRTGATLATETLLTLAGHAGIHGIKD
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
CGGDADKTQRLIADGRLQVLAGEDAQVFGTLCLGGVGAIIASAHVRTALFVEMARAIREQ
CCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDDARRLHHALAPVIRLLFAATNPGPLKAWLAAQGLVRNVLRAPMTVAPEGLQAALAEA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VASV
HHCC
>Mature Secondary Structure
MLEHPSATLPAPSRGRPSYAGIWVPIVTPFLDDAARSVDYGALYALVSRYRTEGIAGFVA
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
CGSTGEAAALTDQEQADVLDTVRAAADGLPVVMGLSGSALAPVRERMLRLAGHHPAAFLV
ECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEE
SPPSYVRPSQAGLLEYFAVLADASSVPLLLYDIPYRTGATLATETLLTLAGHAGIHGIKD
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
CGGDADKTQRLIADGRLQVLAGEDAQVFGTLCLGGVGAIIASAHVRTALFVEMARAIREQ
CCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDDARRLHHALAPVIRLLFAATNPGPLKAWLAAQGLVRNVLRAPMTVAPEGLQAALAEA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VASV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]