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The map label for this gene is moaC

Identifier: 17545279

GI number: 17545279

Start: 605289

End: 605765

Strand: Reverse

Name: moaC

Synonym: RSc0560

Alternate gene names: 17545279

Gene position: 605765-605289 (Counterclockwise)

Preceding gene: 17545281

Following gene: 17545269

Centisome position: 16.3

GC content: 66.25

Gene sequence:

>477_bases
ATGCCGCACCTCACCCACTTCGATACCGCCGGACAAGCCCACATGGTCGACGTCGGCGACAAAGCCGTCACCCACCGCGT
CGCCGTCGCCACCGGCCTCATCCACATGCTGCCCACGACATTCGCGCTGGTGCGCGACGGCACCGCCAAGAAAGGCGATG
TGCTGGGCATCGCCCGCATCGCCGCGATCCAGGGGGCGAAGCGGACGTCGGATTTGATCCCGCTGTGTCACCCACTGGCG
TTGACCAAGGTCGCGGTCGACTTCGAACTGGATGAGGCGGATCGGACCGTCCGCTGCACGGTGCGCGCCGAAACGCACGG
GCAGACCGGCGTGGAAATGGAAGCGCTGACGGCCGTGCAGGTCGGGCTGCTGACCATCTACGACATGTGCAAGGCCGTTG
ACCGGGGGATGGTCATCGGCGATGTGCGGCTGATGGAGAAGCGTGGGGGGAAGTCGGGAGAGTGGGTGGCGCAATGA

Upstream 100 bases:

>100_bases
GCGTCATACGGAATGCGCGTGGGGCGGAATCCACCCGGCGGCATCGCCGGGCGCTGGGCACTTGCTATCATAAATCGCTT
CACACCAAGCACCGTCATCC

Downstream 100 bases:

>100_bases
ATTTCGGCGCCCGTTTCCGCAAAAGGAAGCGGGCGCATCGGATGCGCTCTTCTTTCTGCTCAGCAGCCTTGCGGCATTCA
ACGGGTGCCAATTTTGCTGC

Product: molybdenum cofactor biosynthesis protein MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MPHLTHFDTAGQAHMVDVGDKAVTHRVAVATGLIHMLPTTFALVRDGTAKKGDVLGIARIAAIQGAKRTSDLIPLCHPLA
LTKVAVDFELDEADRTVRCTVRAETHGQTGVEMEALTAVQVGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGEWVAQ

Sequences:

>Translated_158_residues
MPHLTHFDTAGQAHMVDVGDKAVTHRVAVATGLIHMLPTTFALVRDGTAKKGDVLGIARIAAIQGAKRTSDLIPLCHPLA
LTKVAVDFELDEADRTVRCTVRAETHGQTGVEMEALTAVQVGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGEWVAQ
>Mature_157_residues
PHLTHFDTAGQAHMVDVGDKAVTHRVAVATGLIHMLPTTFALVRDGTAKKGDVLGIARIAAIQGAKRTSDLIPLCHPLAL
TKVAVDFELDEADRTVRCTVRAETHGQTGVEMEALTAVQVGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGEWVAQ

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=155, Percent_Identity=56.1290322580645, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=46.3087248322148, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574490, Length=149, Percent_Identity=50.3355704697987, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=50.3649635036496, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_RALSO (Q8Y1X7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518681.1
- ProteinModelPortal:   Q8Y1X7
- SMR:   Q8Y1X7
- GeneID:   1219365
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0560
- NMPDR:   fig|267608.1.peg.560
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- ProtClustDB:   PRK09364
- BioCyc:   RSOL267608:RSC0560-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16956; Mature: 16825

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHLTHFDTAGQAHMVDVGDKAVTHRVAVATGLIHMLPTTFALVRDGTAKKGDVLGIARI
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIQGAKRTSDLIPLCHPLALTKVAVDFELDEADRTVRCTVRAETHGQTGVEMEALTAVQ
HHHCCCCCCCCCCCHHHHHHHHEEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHH
VGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGEWVAQ
HHHHHHHHHHHHHHCCEEEEHEEEHHHCCCCCCCCCCC
>Mature Secondary Structure 
PHLTHFDTAGQAHMVDVGDKAVTHRVAVATGLIHMLPTTFALVRDGTAKKGDVLGIARI
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
AAIQGAKRTSDLIPLCHPLALTKVAVDFELDEADRTVRCTVRAETHGQTGVEMEALTAVQ
HHHCCCCCCCCCCCHHHHHHHHEEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHH
VGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGEWVAQ
HHHHHHHHHHHHHHCCEEEEHEEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852