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The map label for this gene is pqqL [C]

Identifier: 17545106

GI number: 17545106

Start: 415124

End: 416629

Strand: Direct

Name: pqqL [C]

Synonym: RSc0387

Alternate gene names: 17545106

Gene position: 415124-416629 (Clockwise)

Preceding gene: 17545104

Following gene: 17545107

Centisome position: 11.17

GC content: 67.13

Gene sequence:

>1506_bases
ATGCGCTCTTTCCCGCAATCCGTTTCAAATTCCGCCCGGACCGGCCTGCGCTGGGCGGGCATCACTCTGGCGGTCGCCCT
GCTGGCCGGCGAGGCCGGTGCGCAGGCGCCGGCCCCGATGGCGGCGCGCCAGGCCGCCGCGCTCACCGGCGCCAAGGTCG
GCACCAGCCAGGCCGATACACACGAATACCGGCTCGCCAACGGCCTGCGCCTGATCGTCAAGGAAGACCATCGCGCGCCC
ACCGTCGCCCACATGGTGTGGTACCACGCCGGCAGCATCGATGAGCACAACGGCACCACCGGTGTCGCCCACATGCTCGA
GCACATGATGTTCAAGGGCACCCGGGCCGTCGGCCCCGGCGAGTTCTCGCGCCGCGTCGCCGCCCTGGGCGGCCGCGAGA
ACGCCATGACCACGCGCGACTTCACGATGTACTTCCAGCAGATCGAGAAGTCGCACCTGGCCGACGTGATGGCGCTCGAA
GCCGACCGCATGGCCAACCTCCAGCTGACCGACAAGGAATTCAAGCCGGAGATGAACGTGGTCAAGGAAGAGCGCCGCAT
GCGCATCGACGATTCCGCCCGCGCCACGGTCTACGAGCAGATGCTTGCCGTGCTCTTCAACGCCGCGCCGTACCGCAACC
CGACCATCGGCTGGCCGTCCGACCTCGACACGATGACGGTGCAGGACGCGCAGGACTGGTATCACAAGTGGTACGCGCCC
AACAACGCGACGGTGGTCGTCACCGGCGACGTCAACCCGGACGAGGTCTTCCGCCAGGCCCAGCGCACCTACGGCAAGCT
CCAGCCGCATGCGCTGCCGCGCCGCTACGCGCAGGACGAGCCCAAGCAGGTCGGCGTCAAGCGCATCTGGGTCAAGGCGC
CGGCCGAGAATCCCTATGTGGTGCTCGCCTACAAGGCGCCGCCGCTGCGGGACGTGGAGAAGGATGTCGATCCGTATGCG
CTGGAAGTGCTGTCCGCCGTGCTCGACGGCTACGACAACGCCCGTTTGCCCAACCTGCTGGTCAAGGGCAAGGATGAAAA
AGGCGGGCGTCTCGCCGATGACGTCAACGCCGGCTACGACGGCATGAACCGCGGCCCGTCGATCTTCCTGCTGGACGGCG
TGCCCGCCGACGGCCACACCACCGCCGAGATCGAGCAGGCGCTGCGCGCGCAGATCGACCGCATCGCCAGGGATGGCGTG
ACCGAAGCCGAGCTCAAGCGCGTCAAGGCGCAGGTCGTGGCCGCGCAGATCTACAAGCGCGATTCGGTGTTCGGCCAGGG
CATGGAAATCGGCATGGCCGAGATGACCGGCCTGTCGTGGCGCGATCTGGACCGCATTCTGGAGAAGATCAAGTCCGTGA
CGCCCGCGCAGGTCCAACAGGTCGCCAAGACCTACTTCACTGAAGACAACCTGGTCGTGGCGACACTGTTGCCGCAACCG
ATCGACCCGAACAAGCCGGCGCGCAAGCCCGTTCCCGGCATGCGCGAAGAAGGAGGGCTGCGTTGA

Upstream 100 bases:

>100_bases
GCTGGGGCTCTGCCTTGCGCTTCTTCCAGAAACTAAACATCGTAAAAGGCAGTCAATTTCGCCGTTAGAATCAAGCGTCG
AATTTTATCAGACGGCCTCT

Downstream 100 bases:

>100_bases
TGCGCGCCATGTCCCTGACCCTGAAGACGTTCCTGGCCGGCATGCTGGCCGCCGCGGCGCACGGTGCGCTGGCCGCGCTG
CCGATCGAGCACTGGACGGC

Product: zinc protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MRSFPQSVSNSARTGLRWAGITLAVALLAGEAGAQAPAPMAARQAAALTGAKVGTSQADTHEYRLANGLRLIVKEDHRAP
TVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTRAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMALE
ADRMANLQLTDKEFKPEMNVVKEERRMRIDDSARATVYEQMLAVLFNAAPYRNPTIGWPSDLDTMTVQDAQDWYHKWYAP
NNATVVVTGDVNPDEVFRQAQRTYGKLQPHALPRRYAQDEPKQVGVKRIWVKAPAENPYVVLAYKAPPLRDVEKDVDPYA
LEVLSAVLDGYDNARLPNLLVKGKDEKGGRLADDVNAGYDGMNRGPSIFLLDGVPADGHTTAEIEQALRAQIDRIARDGV
TEAELKRVKAQVVAAQIYKRDSVFGQGMEIGMAEMTGLSWRDLDRILEKIKSVTPAQVQQVAKTYFTEDNLVVATLLPQP
IDPNKPARKPVPGMREEGGLR

Sequences:

>Translated_501_residues
MRSFPQSVSNSARTGLRWAGITLAVALLAGEAGAQAPAPMAARQAAALTGAKVGTSQADTHEYRLANGLRLIVKEDHRAP
TVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTRAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMALE
ADRMANLQLTDKEFKPEMNVVKEERRMRIDDSARATVYEQMLAVLFNAAPYRNPTIGWPSDLDTMTVQDAQDWYHKWYAP
NNATVVVTGDVNPDEVFRQAQRTYGKLQPHALPRRYAQDEPKQVGVKRIWVKAPAENPYVVLAYKAPPLRDVEKDVDPYA
LEVLSAVLDGYDNARLPNLLVKGKDEKGGRLADDVNAGYDGMNRGPSIFLLDGVPADGHTTAEIEQALRAQIDRIARDGV
TEAELKRVKAQVVAAQIYKRDSVFGQGMEIGMAEMTGLSWRDLDRILEKIKSVTPAQVQQVAKTYFTEDNLVVATLLPQP
IDPNKPARKPVPGMREEGGLR
>Mature_501_residues
MRSFPQSVSNSARTGLRWAGITLAVALLAGEAGAQAPAPMAARQAAALTGAKVGTSQADTHEYRLANGLRLIVKEDHRAP
TVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTRAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMALE
ADRMANLQLTDKEFKPEMNVVKEERRMRIDDSARATVYEQMLAVLFNAAPYRNPTIGWPSDLDTMTVQDAQDWYHKWYAP
NNATVVVTGDVNPDEVFRQAQRTYGKLQPHALPRRYAQDEPKQVGVKRIWVKAPAENPYVVLAYKAPPLRDVEKDVDPYA
LEVLSAVLDGYDNARLPNLLVKGKDEKGGRLADDVNAGYDGMNRGPSIFLLDGVPADGHTTAEIEQALRAQIDRIARDGV
TEAELKRVKAQVVAAQIYKRDSVFGQGMEIGMAEMTGLSWRDLDRILEKIKSVTPAQVQQVAKTYFTEDNLVVATLLPQP
IDPNKPARKPVPGMREEGGLR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=221, Percent_Identity=26.2443438914027, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI94538354, Length=201, Percent_Identity=25.3731343283582, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787770, Length=213, Percent_Identity=30.0469483568075, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=204, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17553678, Length=215, Percent_Identity=26.9767441860465, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=208, Percent_Identity=21.6346153846154, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357875, Length=234, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646943, Length=234, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 55424; Mature: 55424

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSFPQSVSNSARTGLRWAGITLAVALLAGEAGAQAPAPMAARQAAALTGAKVGTSQADT
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCH
HEYRLANGLRLIVKEDHRAPTVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTRAVGPG
HHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMALEADRMANLQLTDKEFKPEMNV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHCCCHHHH
VKEERRMRIDDSARATVYEQMLAVLFNAAPYRNPTIGWPSDLDTMTVQDAQDWYHKWYAP
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCC
NNATVVVTGDVNPDEVFRQAQRTYGKLQPHALPRRYAQDEPKQVGVKRIWVKAPAENPYV
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHCCCEEEEEECCCCCCEE
VLAYKAPPLRDVEKDVDPYALEVLSAVLDGYDNARLPNLLVKGKDEKGGRLADDVNAGYD
EEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHCCCCCC
GMNRGPSIFLLDGVPADGHTTAEIEQALRAQIDRIARDGVTEAELKRVKAQVVAAQIYKR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DSVFGQGMEIGMAEMTGLSWRDLDRILEKIKSVTPAQVQQVAKTYFTEDNLVVATLLPQP
HHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCC
IDPNKPARKPVPGMREEGGLR
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSFPQSVSNSARTGLRWAGITLAVALLAGEAGAQAPAPMAARQAAALTGAKVGTSQADT
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCH
HEYRLANGLRLIVKEDHRAPTVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTRAVGPG
HHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
EFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMALEADRMANLQLTDKEFKPEMNV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHCCCHHHH
VKEERRMRIDDSARATVYEQMLAVLFNAAPYRNPTIGWPSDLDTMTVQDAQDWYHKWYAP
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCC
NNATVVVTGDVNPDEVFRQAQRTYGKLQPHALPRRYAQDEPKQVGVKRIWVKAPAENPYV
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHCCCEEEEEECCCCCCEE
VLAYKAPPLRDVEKDVDPYALEVLSAVLDGYDNARLPNLLVKGKDEKGGRLADDVNAGYD
EEEECCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHCCCCCC
GMNRGPSIFLLDGVPADGHTTAEIEQALRAQIDRIARDGVTEAELKRVKAQVVAAQIYKR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DSVFGQGMEIGMAEMTGLSWRDLDRILEKIKSVTPAQVQQVAKTYFTEDNLVVATLLPQP
HHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCC
IDPNKPARKPVPGMREEGGLR
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]