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The map label for this gene is melC2 [H]

Identifier: 17545056

GI number: 17545056

Start: 368449

End: 369939

Strand: Reverse

Name: melC2 [H]

Synonym: RSc0337

Alternate gene names: 17545056

Gene position: 369939-368449 (Counterclockwise)

Preceding gene: 17545057

Following gene: 17545055

Centisome position: 9.95

GC content: 64.25

Gene sequence:

>1491_bases
ATGGTCGTGCGTAGAACGGTGCTGAAGGCAATCGCCGGGACAAGTGTCGCCACGGTATTCGCGGGCAAGCTGACCGGCCT
CTCCGCTGTTGCGGCCGATGCCGCCCCGCTGCGCGTGCGGCGCAACCTGCATGGCATGAAGATGGACGACCCGGACCTGT
CGGCCTATCGCGAGTTCGTCGGCATCATGAAAGGCAAGGACCAGACGCAGGCGCTGAGCTGGCTCGGCTTTGCCAACCAG
CACGGTACGCTCAACGGCGGCTACAAGTACTGCCCGCACGGCGACTGGTACTTCCTGCCCTGGCACCGCGGCTTCGTGCT
GATGTACGAGCGCGCCGTGGCCGCGCTCACCGGCTACAAGACCTTCGCCATGCCGTACTGGAACTGGACCGAAGACCGCC
TGCTGCCCGAAGCCTTCACCGCCAAGACCTACAACGGCAAGACGAACCCGCTCTACGTGCCCAACCGGAATGAGCTGACC
GGCCCCTACGCGCTCACCGACGCCATCGTCGGCCAGAAGGAGGTCATGGACAAGATCTATGCCGAAACCAACTTCGAAGT
CTTCGGCACCAGCCGTTCGGTCGACCGCTCGGTCCGGCCGCCGCTGGTACAGAACAGCCTCGACCCCAAATGGGTGCCGA
TGGGAGGCGGCAACCAGGGCATCCTGGAGCGCACGCCGCACAACACCGTCCACAACAACATCGGCGCCTTCATGCCCACC
GCCGCCTCGCCGCGCGACCCGGTGTTCATGATGCACCACGGCAATATCGACCGGGTATGGGCCACCTGGAACGCGCTGGG
CCGCAAGAACTCGACTGACCCGCTGTGGCTGGGCATGAAGTTCCCCAACAACTACATCGATCCGCAGGGCCGGTACTACA
CGCAAGGCGTGAGCGATCTGCTGAGCACCGAGGCGCTGGGCTACCGCTATGACGTCATGCCGCGCGCCGACAACAAGGTG
GTGAACAACGCCCGTGCCGAGCATCTGCTGGCCCTGTTCAAGACCGGCGACAGCGTCAAGCTGGCCGATCATATCCGGCT
GCGCAGCGTGCTGAAGGGGGAACATCCGGTTGCCACGGCGGTCGAACCGCTCAACAGCGCCGTCCAGTTCGAGGCCGGCA
CCGTGACGGGTGCCCTGGGTGCCGATGTTGGTACCGGCAGTACCACCGAAGTCGTGGCCCTGATCAAGAACATCAGGATC
CCCTACAACGTGATCAGCATCCGGGTCTTCGTCAACCTGCCGAACGCCAACCTCGATGTGCCGGAAACCGACCCGCACTT
CGTCACCTCGCTCAGCTTCCTGACGCATGCGGCGGGACACGACCACCATGCCCTGCCGTCGACCATGGTGAACCTGACCG
ACACGCTGAAGGCGCTCAACATCCGGGACGACAACTTTTCGATCAACCTGGTGGCCGTACCCCAACCCGGCGTTGCCGTG
GAGAGCAGCGGCGGCGTGACGCCCGAATCGATCGAGGTCGCCGTCATTTGA

Upstream 100 bases:

>100_bases
TTGAAGTGCCCGCTGCACATTGCAGGGGCGGGCATCCGGGCGGCCAGCCTTCCTGCACCGCCCCATCACAACACCAAGAA
ATCCATCCAGGAGAAATGCA

Downstream 100 bases:

>100_bases
TTGATGGATTGCCCAGGCGCGCGGCCTCGCCGCGCGCCATGCGAGGATGCCGATGTTCCATACCGCCCGCCGATGGTTCT
TCCTGGCACTCTTTGCCGCG

Product: polyphenol oxidase B precursor

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MVVRRTVLKAIAGTSVATVFAGKLTGLSAVAADAAPLRVRRNLHGMKMDDPDLSAYREFVGIMKGKDQTQALSWLGFANQ
HGTLNGGYKYCPHGDWYFLPWHRGFVLMYERAVAALTGYKTFAMPYWNWTEDRLLPEAFTAKTYNGKTNPLYVPNRNELT
GPYALTDAIVGQKEVMDKIYAETNFEVFGTSRSVDRSVRPPLVQNSLDPKWVPMGGGNQGILERTPHNTVHNNIGAFMPT
AASPRDPVFMMHHGNIDRVWATWNALGRKNSTDPLWLGMKFPNNYIDPQGRYYTQGVSDLLSTEALGYRYDVMPRADNKV
VNNARAEHLLALFKTGDSVKLADHIRLRSVLKGEHPVATAVEPLNSAVQFEAGTVTGALGADVGTGSTTEVVALIKNIRI
PYNVISIRVFVNLPNANLDVPETDPHFVTSLSFLTHAAGHDHHALPSTMVNLTDTLKALNIRDDNFSINLVAVPQPGVAV
ESSGGVTPESIEVAVI

Sequences:

>Translated_496_residues
MVVRRTVLKAIAGTSVATVFAGKLTGLSAVAADAAPLRVRRNLHGMKMDDPDLSAYREFVGIMKGKDQTQALSWLGFANQ
HGTLNGGYKYCPHGDWYFLPWHRGFVLMYERAVAALTGYKTFAMPYWNWTEDRLLPEAFTAKTYNGKTNPLYVPNRNELT
GPYALTDAIVGQKEVMDKIYAETNFEVFGTSRSVDRSVRPPLVQNSLDPKWVPMGGGNQGILERTPHNTVHNNIGAFMPT
AASPRDPVFMMHHGNIDRVWATWNALGRKNSTDPLWLGMKFPNNYIDPQGRYYTQGVSDLLSTEALGYRYDVMPRADNKV
VNNARAEHLLALFKTGDSVKLADHIRLRSVLKGEHPVATAVEPLNSAVQFEAGTVTGALGADVGTGSTTEVVALIKNIRI
PYNVISIRVFVNLPNANLDVPETDPHFVTSLSFLTHAAGHDHHALPSTMVNLTDTLKALNIRDDNFSINLVAVPQPGVAV
ESSGGVTPESIEVAVI
>Mature_496_residues
MVVRRTVLKAIAGTSVATVFAGKLTGLSAVAADAAPLRVRRNLHGMKMDDPDLSAYREFVGIMKGKDQTQALSWLGFANQ
HGTLNGGYKYCPHGDWYFLPWHRGFVLMYERAVAALTGYKTFAMPYWNWTEDRLLPEAFTAKTYNGKTNPLYVPNRNELT
GPYALTDAIVGQKEVMDKIYAETNFEVFGTSRSVDRSVRPPLVQNSLDPKWVPMGGGNQGILERTPHNTVHNNIGAFMPT
AASPRDPVFMMHHGNIDRVWATWNALGRKNSTDPLWLGMKFPNNYIDPQGRYYTQGVSDLLSTEALGYRYDVMPRADNKV
VNNARAEHLLALFKTGDSVKLADHIRLRSVLKGEHPVATAVEPLNSAVQFEAGTVTGALGADVGTGSTTEVVALIKNIRI
PYNVISIRVFVNLPNANLDVPETDPHFVTSLSFLTHAAGHDHHALPSTMVNLTDTLKALNIRDDNFSINLVAVPQPGVAV
ESSGGVTPESIEVAVI

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 54452; Mature: 54452

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00497 TYROSINASE_1 ; PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVRRTVLKAIAGTSVATVFAGKLTGLSAVAADAAPLRVRRNLHGMKMDDPDLSAYREFV
CCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHH
GIMKGKDQTQALSWLGFANQHGTLNGGYKYCPHGDWYFLPWHRGFVLMYERAVAALTGYK
HHHCCCCHHHHHHHHEECCCCCCCCCCEEECCCCCEEEECCCCCEEEEHHHHHHHHHCCC
TFAMPYWNWTEDRLLPEAFTAKTYNGKTNPLYVPNRNELTGPYALTDAIVGQKEVMDKIY
EEECCCCCCCHHHCCCHHHHEECCCCCCCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHH
AETNFEVFGTSRSVDRSVRPPLVQNSLDPKWVPMGGGNQGILERTPHNTVHNNIGAFMPT
HCCCEEEEECCCCCCCCCCCCHHHCCCCCCEEECCCCCCCCEECCCCCHHHCCCCCCCCC
AASPRDPVFMMHHGNIDRVWATWNALGRKNSTDPLWLGMKFPNNYIDPQGRYYTQGVSDL
CCCCCCCEEEEECCCCCEEEEEHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHH
LSTEALGYRYDVMPRADNKVVNNARAEHLLALFKTGDSVKLADHIRLRSVLKGEHPVATA
HHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
VEPLNSAVQFEAGTVTGALGADVGTGSTTEVVALIKNIRIPYNVISIRVFVNLPNANLDV
HHHHCHHEEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCC
PETDPHFVTSLSFLTHAAGHDHHALPSTMVNLTDTLKALNIRDDNFSINLVAVPQPGVAV
CCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCEEEEEEEECCCCEEE
ESSGGVTPESIEVAVI
ECCCCCCCCCEEEEEC
>Mature Secondary Structure
MVVRRTVLKAIAGTSVATVFAGKLTGLSAVAADAAPLRVRRNLHGMKMDDPDLSAYREFV
CCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHH
GIMKGKDQTQALSWLGFANQHGTLNGGYKYCPHGDWYFLPWHRGFVLMYERAVAALTGYK
HHHCCCCHHHHHHHHEECCCCCCCCCCEEECCCCCEEEECCCCCEEEEHHHHHHHHHCCC
TFAMPYWNWTEDRLLPEAFTAKTYNGKTNPLYVPNRNELTGPYALTDAIVGQKEVMDKIY
EEECCCCCCCHHHCCCHHHHEECCCCCCCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHH
AETNFEVFGTSRSVDRSVRPPLVQNSLDPKWVPMGGGNQGILERTPHNTVHNNIGAFMPT
HCCCEEEEECCCCCCCCCCCCHHHCCCCCCEEECCCCCCCCEECCCCCHHHCCCCCCCCC
AASPRDPVFMMHHGNIDRVWATWNALGRKNSTDPLWLGMKFPNNYIDPQGRYYTQGVSDL
CCCCCCCEEEEECCCCCEEEEEHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHH
LSTEALGYRYDVMPRADNKVVNNARAEHLLALFKTGDSVKLADHIRLRSVLKGEHPVATA
HHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHH
VEPLNSAVQFEAGTVTGALGADVGTGSTTEVVALIKNIRIPYNVISIRVFVNLPNANLDV
HHHHCHHEEEECCEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCC
PETDPHFVTSLSFLTHAAGHDHHALPSTMVNLTDTLKALNIRDDNFSINLVAVPQPGVAV
CCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEEEECCCEEEEEEEECCCCEEE
ESSGGVTPESIEVAVI
ECCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3932128 [H]