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The map label for this gene is dac [H]

Identifier: 17545046

GI number: 17545046

Start: 358458

End: 359651

Strand: Reverse

Name: dac [H]

Synonym: RSc0327

Alternate gene names: 17545046

Gene position: 359651-358458 (Counterclockwise)

Preceding gene: 17545047

Following gene: 17545045

Centisome position: 9.68

GC content: 66.92

Gene sequence:

>1194_bases
ATGCAGACCCGTATCCCCTCCCGAGCCCTTCCCTCCGCCGCCGTGACGCTCGTCGCGGCAGCCGTGCTTGCCGCGGCAGC
GCCGGCACTGGCGCAGCCCGTCCCGGCGCCGCAGGTCGCAGCCCGCGCATGGATGCTGACCGATGTGACGAGCGGCCAGG
TGCTGGGCGGCGGCAACGTAGACGAGCGCATCGAGCCCGCCTCGCTGACCAAGCTGATGACCGCGTACCTCGCCGTCGAG
GCCGTGCGCGACGGCAAGCTCAAGTACGACCAGATGCTCACCCCGACCGAGACCGTGCGCAGCGTCAAGACCGACGAGTC
GCGCATGTTCCTGCAGCCCGGCAAGCCCGTCTCGGTACGCGACCTGCTGCAGGGCCTGATCGTGCAGTCGGGCAATGACG
CGGCGCTGGTGCTGGCCGAGGCCGTGGGCGGCACCGAGACCAACTTCGTGATGCTGATGAACCGCGAGGCCGAACGCCTG
GGCATGAAGGGCACGCACTTCATGAACGCCGCCGGCCTGCCCGACCCGAACCACTACACCACGGCGCGCGACCTGTCGAT
CCTGACCGCGGCGCTGATCCGCGATTTCCCCGAGGACTACAAGTTCTATTCGCAGAAGGAATTCACCTATAACAACATCA
AGCAGCCCAACCGCAACCGGCTGCTGTGGATCGACCCGACGGTCGACGGCGTCAAGACCGGCCACACCAAGTCGGCGGGC
TATTGCCTGATCACCTCGGCCAAGCGCCCGCTGCCCGACGTGCCGAACGCGAGCCGCCGCCTGCTGTCGGTGATGATCGG
CACCAAGAGCGAACAGGTCCGCACGCAGGAGAGCCTGAAGGTGCTCAACTACGGCTACCAGTTCTTCGACACCCTGCGCC
TGTACGAAGCCAAGCAGGCGCTGCAGACGCCCGACGTCTACAAGGGCCAGGCCAAGACCGTCAAGCTCGGCGTGGCGGAA
GACAAGTGGATCACGGTGCCCAAGGGCTCGGGCGGCCGCCTCAAGCCGGTGCTCGAGCGCAAGGAGCCGCTGATCGCCCC
GATCGCGCAGGGCCAGCAGCTGGGCACGGTCAAGGTGATGGACGGCGCGACCGTGGTGCAGGAGTTCCCGGTGGTGGCGC
TGGAAGCCGTGCCCGAAGCCGGATTCATCGGCCGCACCATCGATTCGATCAAGCTGTGGTTCAAGAAGAAGTAA

Upstream 100 bases:

>100_bases
TGGACGCCGCGCTCGTAGCCCCGTTATTACCGTTTTCCCGGACGCTGGGCTCCCCCCGGCCGCAGCGTCGTTGTCTACCA
AGCAGATCGCAGGACCCGCC

Downstream 100 bases:

>100_bases
GCCCCCCGCGACAGACCCCATGACCGACGCCAACGACACCCCCGCCACCCCGCCGCGCGAATCGCTGATCGAGTATCCGA
GCGACTTCCCCATCAAGGTG

Product: penicillin-binding transmembrane protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQTRIPSRALPSAAVTLVAAAVLAAAAPALAQPVPAPQVAARAWMLTDVTSGQVLGGGNVDERIEPASLTKLMTAYLAVE
AVRDGKLKYDQMLTPTETVRSVKTDESRMFLQPGKPVSVRDLLQGLIVQSGNDAALVLAEAVGGTETNFVMLMNREAERL
GMKGTHFMNAAGLPDPNHYTTARDLSILTAALIRDFPEDYKFYSQKEFTYNNIKQPNRNRLLWIDPTVDGVKTGHTKSAG
YCLITSAKRPLPDVPNASRRLLSVMIGTKSEQVRTQESLKVLNYGYQFFDTLRLYEAKQALQTPDVYKGQAKTVKLGVAE
DKWITVPKGSGGRLKPVLERKEPLIAPIAQGQQLGTVKVMDGATVVQEFPVVALEAVPEAGFIGRTIDSIKLWFKKK

Sequences:

>Translated_397_residues
MQTRIPSRALPSAAVTLVAAAVLAAAAPALAQPVPAPQVAARAWMLTDVTSGQVLGGGNVDERIEPASLTKLMTAYLAVE
AVRDGKLKYDQMLTPTETVRSVKTDESRMFLQPGKPVSVRDLLQGLIVQSGNDAALVLAEAVGGTETNFVMLMNREAERL
GMKGTHFMNAAGLPDPNHYTTARDLSILTAALIRDFPEDYKFYSQKEFTYNNIKQPNRNRLLWIDPTVDGVKTGHTKSAG
YCLITSAKRPLPDVPNASRRLLSVMIGTKSEQVRTQESLKVLNYGYQFFDTLRLYEAKQALQTPDVYKGQAKTVKLGVAE
DKWITVPKGSGGRLKPVLERKEPLIAPIAQGQQLGTVKVMDGATVVQEFPVVALEAVPEAGFIGRTIDSIKLWFKKK
>Mature_397_residues
MQTRIPSRALPSAAVTLVAAAVLAAAAPALAQPVPAPQVAARAWMLTDVTSGQVLGGGNVDERIEPASLTKLMTAYLAVE
AVRDGKLKYDQMLTPTETVRSVKTDESRMFLQPGKPVSVRDLLQGLIVQSGNDAALVLAEAVGGTETNFVMLMNREAERL
GMKGTHFMNAAGLPDPNHYTTARDLSILTAALIRDFPEDYKFYSQKEFTYNNIKQPNRNRLLWIDPTVDGVKTGHTKSAG
YCLITSAKRPLPDVPNASRRLLSVMIGTKSEQVRTQESLKVLNYGYQFFDTLRLYEAKQALQTPDVYKGQAKTVKLGVAE
DKWITVPKGSGGRLKPVLERKEPLIAPIAQGQQLGTVKVMDGATVVQEFPVVALEAVPEAGFIGRTIDSIKLWFKKK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=395, Percent_Identity=40.5063291139241, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1786851, Length=409, Percent_Identity=38.3863080684597, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87082022, Length=379, Percent_Identity=38.2585751978892, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082054, Length=220, Percent_Identity=32.2727272727273, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43321; Mature: 43321

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRIPSRALPSAAVTLVAAAVLAAAAPALAQPVPAPQVAARAWMLTDVTSGQVLGGGNV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCCEECCCCC
DERIEPASLTKLMTAYLAVEAVRDGKLKYDQMLTPTETVRSVKTDESRMFLQPGKPVSVR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHCCCCCEEEECCCCCCCHH
DLLQGLIVQSGNDAALVLAEAVGGTETNFVMLMNREAERLGMKGTHFMNAAGLPDPNHYT
HHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCEECCCCCCCCCCCC
TARDLSILTAALIRDFPEDYKFYSQKEFTYNNIKQPNRNRLLWIDPTVDGVKTGHTKSAG
CHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
YCLITSAKRPLPDVPNASRRLLSVMIGTKSEQVRTQESLKVLNYGYQFFDTLRLYEAKQA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTPDVYKGQAKTVKLGVAEDKWITVPKGSGGRLKPVLERKEPLIAPIAQGQQLGTVKVM
HCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHCCCCCEEECCCCCCCCEEEEE
DGATVVQEFPVVALEAVPEAGFIGRTIDSIKLWFKKK
CCHHHHHHCCEEEEECCCCCCCCCCCHHHEEEEEECC
>Mature Secondary Structure
MQTRIPSRALPSAAVTLVAAAVLAAAAPALAQPVPAPQVAARAWMLTDVTSGQVLGGGNV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCCEECCCCC
DERIEPASLTKLMTAYLAVEAVRDGKLKYDQMLTPTETVRSVKTDESRMFLQPGKPVSVR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHCCCCCEEEECCCCCCCHH
DLLQGLIVQSGNDAALVLAEAVGGTETNFVMLMNREAERLGMKGTHFMNAAGLPDPNHYT
HHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCEECCCCCCCCCCCC
TARDLSILTAALIRDFPEDYKFYSQKEFTYNNIKQPNRNRLLWIDPTVDGVKTGHTKSAG
CHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
YCLITSAKRPLPDVPNASRRLLSVMIGTKSEQVRTQESLKVLNYGYQFFDTLRLYEAKQA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTPDVYKGQAKTVKLGVAEDKWITVPKGSGGRLKPVLERKEPLIAPIAQGQQLGTVKVM
HCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCHHHHCCCCCEEECCCCCCCCEEEEE
DGATVVQEFPVVALEAVPEAGFIGRTIDSIKLWFKKK
CCHHHHHHCCEEEEECCCCCCCCCCCHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]