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The map label for this gene is vsrA [H]

Identifier: 17545008

GI number: 17545008

Start: 321920

End: 323344

Strand: Direct

Name: vsrA [H]

Synonym: RSc0289

Alternate gene names: 17545008

Gene position: 321920-323344 (Clockwise)

Preceding gene: 17545007

Following gene: 17545015

Centisome position: 8.66

GC content: 68.0

Gene sequence:

>1425_bases
ATGCGGTCATCTCTGCGCTCCACCCTGCTGCTTGCCGGCGGCATCCTGCTGACGCTGGGCGTGCTGATTGCGTCCGAGAC
GGGCAACATTCGCTTGAGCCAGGGCTACCGGCAGGTGATCCAGTCGCAGCAGGCCGAAACCGCCATCAATGAACTGCTCG
CCGAACTCGTCAACGCGGAGGCCGGTCAGCGCGGCTTCCTGCTCACGGGCAAGGACGAGTACCTCGATCCCTACAACAAG
GCCATCCCGCACATCCACGCGCTGATGGCGGAAATCCGCGACCACTACGCCAACGATCCCGAAGCGCTGAAGCTGTTCTC
CGATACCGCGCTGCAGGTCAGCCGCAAGCTCACCGAGATGGAGCTCACGCTGATCTACGGCAAGCGCGACCTGGAGGTGG
CGCTGGACCTGATCCGCACGGATTTCGGCAAGGCGTCGATGGAGGCGGTGCGCCAGGGCCTGGACCGACTGCGCCAGCGC
GAGATCGGTACGGTGGCGCGCAGCCTGGAGCACGCCGAGCGCGATCTGGCGCTGTCGCGCTACGGCATCGCGCTGATCAC
CGCGGTCAACATCATCCTGCTGGTGGTGCTGGGCATGCAGCACGCCAGGCGCCTGGCCGCCACCGAGCGGGAGCGCGACA
AGCTCGAAGAGGAAAGCCAGAAGCTCGACCGCATGGTGCGCGAGCGCACGCGGCAGCTGTCGGACCTCGCCGCCCACCTG
CAGCGTGTGACCGAGGACGAGAAGACGCGCCTGGCGCGCGAACTGCACGATGAGCTGGGCGCCCTCCTGACCGCCACCAA
GATGGACCTGCACTGGCTGCGCTCGCGCATCACGGTCTCCGAGCCGGCCGTGGCGGACAAGATCACGCGCGTGATGGCCC
ACGTCGACCAGGGCATCCAGATCAAGCGCCGCCTGATCGAAGACCTGCGGCCGACCATCCTGCTCAATCTGGGCCTGGCC
GAGGCCATCACGCAGCTGACCGAAGACGTCGGCACGCGCAATCAGTGGCAGACCGAGGTCAGCCTGCCCGACGAGATGCC
CAAGCTCACCGACGACGCGGCCATCGCGCTGTACCGCATCGTGCAGGAGTCGCTGACCAACGCCTCGAAGTATGCGCACG
CGACCATCGTCTCCGTGGCGCTGGATGCGAGCGAGGAGGGCGTGCGGCTGCGCGTGCGCGACAACGGCCGCGGCTTCCCG
GCCGACCTCGAGCGCCGGCGCATGGTCGGCCATCATGGCCTGCTGGGCATGGAGCAGCGCGCCATCGCGCTGGGCGGCAC
ACTGACGATCGACTCGACGCCGGGCGGCGGTGTCACCATCATCGTCGAGCTGCCGCCGACCGATGCGGTGGTCGACCGCG
GCGATGCCGGCAACGGGCCGGCAGGGGACATTCCCTTGGCAGGCAAGGGCAACGCGCTGGTCTGA

Upstream 100 bases:

>100_bases
GCCCCGACCGCCTGGAGGTATGATGCGATTTGCTATAAAAAACACACACAAACGCGCGCCGCGCCGGGCGGCCTGACGCG
TTGCTCACGGTCTGCGTGCC

Downstream 100 bases:

>100_bases
TGCGCGCCGCCCAATAAAAAAGCCCCGTAGCGGGGCCTGTTCGTCATACCGCCCGAGGCGGCTTACATCTTCTGCTTGGC
GTTGTCGGCGGCGTTTTCCA

Product: transmembrane sensor kinase vsrA transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYLDPYNK
AIPHIHALMAEIRDHYANDPEALKLFSDTALQVSRKLTEMELTLIYGKRDLEVALDLIRTDFGKASMEAVRQGLDRLRQR
EIGTVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHARRLAATERERDKLEEESQKLDRMVRERTRQLSDLAAHL
QRVTEDEKTRLARELHDELGALLTATKMDLHWLRSRITVSEPAVADKITRVMAHVDQGIQIKRRLIEDLRPTILLNLGLA
EAITQLTEDVGTRNQWQTEVSLPDEMPKLTDDAAIALYRIVQESLTNASKYAHATIVSVALDASEEGVRLRVRDNGRGFP
ADLERRRMVGHHGLLGMEQRAIALGGTLTIDSTPGGGVTIIVELPPTDAVVDRGDAGNGPAGDIPLAGKGNALV

Sequences:

>Translated_474_residues
MRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYLDPYNK
AIPHIHALMAEIRDHYANDPEALKLFSDTALQVSRKLTEMELTLIYGKRDLEVALDLIRTDFGKASMEAVRQGLDRLRQR
EIGTVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHARRLAATERERDKLEEESQKLDRMVRERTRQLSDLAAHL
QRVTEDEKTRLARELHDELGALLTATKMDLHWLRSRITVSEPAVADKITRVMAHVDQGIQIKRRLIEDLRPTILLNLGLA
EAITQLTEDVGTRNQWQTEVSLPDEMPKLTDDAAIALYRIVQESLTNASKYAHATIVSVALDASEEGVRLRVRDNGRGFP
ADLERRRMVGHHGLLGMEQRAIALGGTLTIDSTPGGGVTIIVELPPTDAVVDRGDAGNGPAGDIPLAGKGNALV
>Mature_474_residues
MRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYLDPYNK
AIPHIHALMAEIRDHYANDPEALKLFSDTALQVSRKLTEMELTLIYGKRDLEVALDLIRTDFGKASMEAVRQGLDRLRQR
EIGTVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHARRLAATERERDKLEEESQKLDRMVRERTRQLSDLAAHL
QRVTEDEKTRLARELHDELGALLTATKMDLHWLRSRITVSEPAVADKITRVMAHVDQGIQIKRRLIEDLRPTILLNLGLA
EAITQLTEDVGTRNQWQTEVSLPDEMPKLTDDAAIALYRIVQESLTNASKYAHATIVSVALDASEEGVRLRVRDNGRGFP
ADLERRRMVGHHGLLGMEQRAIALGGTLTIDSTPGGGVTIIVELPPTDAVVDRGDAGNGPAGDIPLAGKGNALV

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates vraR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=211, Percent_Identity=32.2274881516588, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787474, Length=266, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR017202 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52288; Mature: 52288

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGQRGFLLTGKDEYLDPYNKAIPHIHALMAEIRDHYANDPEALKLFSDTALQVSRKLTEM
CCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELTLIYGKRDLEVALDLIRTDFGKASMEAVRQGLDRLRQREIGTVARSLEHAERDLALSR
EEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGIALITAVNIILLVVLGMQHARRLAATERERDKLEEESQKLDRMVRERTRQLSDLAAHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRVTEDEKTRLARELHDELGALLTATKMDLHWLRSRITVSEPAVADKITRVMAHVDQGIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IKRRLIEDLRPTILLNLGLAEAITQLTEDVGTRNQWQTEVSLPDEMPKLTDDAAIALYRI
HHHHHHHHCCHHEEECCCHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCCCHHHHHHHHH
VQESLTNASKYAHATIVSVALDASEEGVRLRVRDNGRGFPADLERRRMVGHHGLLGMEQR
HHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHH
AIALGGTLTIDSTPGGGVTIIVELPPTDAVVDRGDAGNGPAGDIPLAGKGNALV
HEEECCEEEEECCCCCCEEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGQRGFLLTGKDEYLDPYNKAIPHIHALMAEIRDHYANDPEALKLFSDTALQVSRKLTEM
CCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELTLIYGKRDLEVALDLIRTDFGKASMEAVRQGLDRLRQREIGTVARSLEHAERDLALSR
EEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGIALITAVNIILLVVLGMQHARRLAATERERDKLEEESQKLDRMVRERTRQLSDLAAHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRVTEDEKTRLARELHDELGALLTATKMDLHWLRSRITVSEPAVADKITRVMAHVDQGIQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IKRRLIEDLRPTILLNLGLAEAITQLTEDVGTRNQWQTEVSLPDEMPKLTDDAAIALYRI
HHHHHHHHCCHHEEECCCHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCCCHHHHHHHHH
VQESLTNASKYAHATIVSVALDASEEGVRLRVRDNGRGFPADLERRRMVGHHGLLGMEQR
HHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHH
AIALGGTLTIDSTPGGGVTIIVELPPTDAVVDRGDAGNGPAGDIPLAGKGNALV
HEEECCEEEEECCCCCCEEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA