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The map label for this gene is paaH1 [H]

Identifier: 17544963

GI number: 17544963

Start: 268557

End: 269411

Strand: Direct

Name: paaH1 [H]

Synonym: RSc0244

Alternate gene names: 17544963

Gene position: 268557-269411 (Clockwise)

Preceding gene: 17544956

Following gene: 17544966

Centisome position: 7.23

GC content: 67.37

Gene sequence:

>855_bases
ATGGCAATTCAGACGGTAGGGATCGTGGGTGCAGGCACGATGGGCAACGGCATTGCGCAGGCATGCGCCGTGGCCGGGCT
GGACGTGGTGATGGTGGACATCAGCGAGGCCGCCGTGCAGAAGGGGCTTGCCACCGTGGCCGGCAGCCTGGACCGGCTGA
TCAAGAAAGAGAAGCTGACCGAGGCCGACAAGGCCGCCGCGCTCGCGCGCATCCACGGCGCCACCGCATACGGCGACCTC
AAGCGCGCCGACATCGTGATCGAGGCCGCCACCGAGAACCTCGACCTGAAGATCAAGATCCTCGGGCAGCTCGAGGCCGT
CGCCGCGCCGCACGCCATCATCGCGTCCAACACGTCGTCGATCTCGATCACCAAGCTGGCCGCCGTGCTGCAGGACGCCA
GCCGCTTCATCGGCATGCACTTCTTCAACCCGGTGCCGATGATGGCGCTGGTGGAGATCATTCGCGGCCTGCAGACCGGC
GACGCCACGCACGCCGCCGTCGAAGCGCTGGCGCAGCGGCTCGGCAAGACGCCGATCACGGTCAAGAACAGCCCGGGCTT
CGTCGTCAACCGCATCCTGTGCCCGATGATCAACGAGGCGTTCTGCGCGCTGGGCGAGGGGCTGGCGACGCCCGAGGAGA
TCGACGAAGGCATGAAGCTCGGCTGCAACCATCCGATCGGGCCGCTGGCGCTGGCCGACATGATCGGCCTGGACACCATG
CTGGCCGTGATGGAGGTGCTCCACACCGAGTTCGGCGACCCGAAATACCGGCCGGCCATGCTGCTGCGCGAGATGGTCGC
CGCCGGCTACCTGGGGCGCAAGAGCGGACGCGGGGTGTACGACTACCGCAAGTGA

Upstream 100 bases:

>100_bases
CCGCCGGGCCGGCGCGGGGCGCGTTCCCTTTCCGCCGGTTCGCGCAGTCGATTATCCTGTGCCCTCCTTTTGACTGACAC
AGCAAGCGAGGATCGTTTAC

Downstream 100 bases:

>100_bases
GGCGCGCCGGCGGATCGGCGCCGGGTCAGCGCGTACCCGGCGTGTTCGCCAGCGCCATCTTGACCAGGCCGGACATCAGC
TGCCGGGCGTCGGACGGGCA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MAIQTVGIVGAGTMGNGIAQACAVAGLDVVMVDISEAAVQKGLATVAGSLDRLIKKEKLTEADKAAALARIHGATAYGDL
KRADIVIEAATENLDLKIKILGQLEAVAAPHAIIASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEIIRGLQTG
DATHAAVEALAQRLGKTPITVKNSPGFVVNRILCPMINEAFCALGEGLATPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLHTEFGDPKYRPAMLLREMVAAGYLGRKSGRGVYDYRK

Sequences:

>Translated_284_residues
MAIQTVGIVGAGTMGNGIAQACAVAGLDVVMVDISEAAVQKGLATVAGSLDRLIKKEKLTEADKAAALARIHGATAYGDL
KRADIVIEAATENLDLKIKILGQLEAVAAPHAIIASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEIIRGLQTG
DATHAAVEALAQRLGKTPITVKNSPGFVVNRILCPMINEAFCALGEGLATPEEIDEGMKLGCNHPIGPLALADMIGLDTM
LAVMEVLHTEFGDPKYRPAMLLREMVAAGYLGRKSGRGVYDYRK
>Mature_283_residues
AIQTVGIVGAGTMGNGIAQACAVAGLDVVMVDISEAAVQKGLATVAGSLDRLIKKEKLTEADKAAALARIHGATAYGDLK
RADIVIEAATENLDLKIKILGQLEAVAAPHAIIASNTSSISITKLAAVLQDASRFIGMHFFNPVPMMALVEIIRGLQTGD
ATHAAVEALAQRLGKTPITVKNSPGFVVNRILCPMINEAFCALGEGLATPEEIDEGMKLGCNHPIGPLALADMIGLDTML
AVMEVLHTEFGDPKYRPAMLLREMVAAGYLGRKSGRGVYDYRK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=39.1003460207612, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=37.5816993464052, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI20127408, Length=288, Percent_Identity=37.5, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI68989263, Length=298, Percent_Identity=30.5369127516779, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=40.0709219858156, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=38.7832699619772, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=37.218045112782, Blast_Score=164, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17549919, Length=291, Percent_Identity=42.9553264604811, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=41.9243986254296, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=35.9861591695502, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=38.0281690140845, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=37.6760563380282, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=37.6760563380282, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=37.6760563380282, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=30.4195804195804, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=30, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=27.9411764705882, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=38.2978723404255, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=38.2978723404255, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=38.2978723404255, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=31.25, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20129993, Length=224, Percent_Identity=29.4642857142857, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29873; Mature: 29742

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQTVGIVGAGTMGNGIAQACAVAGLDVVMVDISEAAVQKGLATVAGSLDRLIKKEKLT
CCEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EADKAAALARIHGATAYGDLKRADIVIEAATENLDLKIKILGQLEAVAAPHAIIASNTSS
HHHHHHHHHHHHCCHHHCCCHHHHEEEEEECCCCCEEEEEEHHHHHHHCCCEEEECCCCC
ISITKLAAVLQDASRFIGMHFFNPVPMMALVEIIRGLQTGDATHAAVEALAQRLGKTPIT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCALGEGLATPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLHTEFGDPKYRPAMLLREMVAAGYLGRKSGRGVYDYRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIQTVGIVGAGTMGNGIAQACAVAGLDVVMVDISEAAVQKGLATVAGSLDRLIKKEKLT
CEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EADKAAALARIHGATAYGDLKRADIVIEAATENLDLKIKILGQLEAVAAPHAIIASNTSS
HHHHHHHHHHHHCCHHHCCCHHHHEEEEEECCCCCEEEEEEHHHHHHHCCCEEEECCCCC
ISITKLAAVLQDASRFIGMHFFNPVPMMALVEIIRGLQTGDATHAAVEALAQRLGKTPIT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEE
VKNSPGFVVNRILCPMINEAFCALGEGLATPEEIDEGMKLGCNHPIGPLALADMIGLDTM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVMEVLHTEFGDPKYRPAMLLREMVAAGYLGRKSGRGVYDYRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA