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The map label for this gene is fabG [C]

Identifier: 17544890

GI number: 17544890

Start: 192394

End: 193134

Strand: Reverse

Name: fabG [C]

Synonym: RSc0171

Alternate gene names: 17544890

Gene position: 193134-192394 (Counterclockwise)

Preceding gene: 17544891

Following gene: 17544889

Centisome position: 5.2

GC content: 67.34

Gene sequence:

>741_bases
ATGAAGAACATCCTGATCGTTGGAGCCACCTCCGCCATCGCGATCGCCTGTGCGCGGCAATGGGCCGCCGAGGGCGCCCG
CTTCTTTCTGGTGGCACGCAACGGCGAGCGCCTCGAGCAGGTCGCCGACGACCTGAGCGCGCGCGGCGCGCAACTCGCCA
GCCGCCACCAGCTCGACATCACCGACCTGGAGCGCCATGCGGCCATGTTCGAACAGTGCCTGGCCGCGCTGGGCACGATC
GACATCGTCCTGGTCGCCCCGGGAACATTGCCGGACCAGGCGGCCTGCCAGGCGGATCCGGCGATCGCGGTGCGAGAGTT
CAACACCAACGCCACCGCCGTCATCGCCCTGCTGACGCGGATTGCCAATGCGCTCGAGGCCCAGCGCAGCGGCGCGCTGG
CGGTCATTTCGTCGGTGGCGGCGGATCGCGGCCGCCCCTCCAACTATCTGTACGGCAGCGCGAAGGCCGCCCTCTCGGCC
TTTTGCGAAGGACTGAACGCGCGCCTGTTCAAAGCCGGCGTGCACGTCCTGACGATCAAGCCGGGCTTCGTCTCGACACC
GATGACCGCCGGGCTGCCCTTGCCCGGCCCGCTGGTCGCGTCCCCGGAGAAGGTGTCCCGCGACATCGTGCGCGCCATCG
ACAAGCGCAAGGACACGCTGTACACACCGTGGTTCTGGGCGATCATCATGCTGATCATCCGATCGGTGCCGAAGCCTGTT
TTCAAACGGACATCGCTGTAA

Upstream 100 bases:

>100_bases
CCGGCGCGGACTTCCGTGCAGCCTATCCGCAATGGCAACAGCTCGAAGCGCTCCGGGACCCCGCCATGCTGTCACGCTTC
TGGGAACGAACCACTCGAAC

Downstream 100 bases:

>100_bases
ACGCAGGATGCAAATGAAAACGCGGTTCGACGGCGGGTATCTGATTTTCCTCCTCGGCATCATTACGCTCACCACCACGG
TGTACGCGGTCTGGACCCAC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORF3 [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKNILIVGATSAIAIACARQWAAEGARFFLVARNGERLEQVADDLSARGAQLASRHQLDITDLERHAAMFEQCLAALGTI
DIVLVAPGTLPDQAACQADPAIAVREFNTNATAVIALLTRIANALEAQRSGALAVISSVAADRGRPSNYLYGSAKAALSA
FCEGLNARLFKAGVHVLTIKPGFVSTPMTAGLPLPGPLVASPEKVSRDIVRAIDKRKDTLYTPWFWAIIMLIIRSVPKPV
FKRTSL

Sequences:

>Translated_246_residues
MKNILIVGATSAIAIACARQWAAEGARFFLVARNGERLEQVADDLSARGAQLASRHQLDITDLERHAAMFEQCLAALGTI
DIVLVAPGTLPDQAACQADPAIAVREFNTNATAVIALLTRIANALEAQRSGALAVISSVAADRGRPSNYLYGSAKAALSA
FCEGLNARLFKAGVHVLTIKPGFVSTPMTAGLPLPGPLVASPEKVSRDIVRAIDKRKDTLYTPWFWAIIMLIIRSVPKPV
FKRTSL
>Mature_246_residues
MKNILIVGATSAIAIACARQWAAEGARFFLVARNGERLEQVADDLSARGAQLASRHQLDITDLERHAAMFEQCLAALGTI
DIVLVAPGTLPDQAACQADPAIAVREFNTNATAVIALLTRIANALEAQRSGALAVISSVAADRGRPSNYLYGSAKAALSA
FCEGLNARLFKAGVHVLTIKPGFVSTPMTAGLPLPGPLVASPEKVSRDIVRAIDKRKDTLYTPWFWAIIMLIIRSVPKPV
FKRTSL

Specific function: May be involved in the biosynthesis of a heptaene-type antibiotic [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=230, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=28.4974093264249, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=198, Percent_Identity=26.7676767676768, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=224, Percent_Identity=27.6785714285714, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=199, Percent_Identity=25.6281407035176, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=199, Percent_Identity=26.6331658291457, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=28.8659793814433, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=32.2916666666667, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26272; Mature: 26272

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILIVGATSAIAIACARQWAAEGARFFLVARNGERLEQVADDLSARGAQLASRHQLDI
CCCEEEEECHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCH
TDLERHAAMFEQCLAALGTIDIVLVAPGTLPDQAACQADPAIAVREFNTNATAVIALLTR
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHH
IANALEAQRSGALAVISSVAADRGRPSNYLYGSAKAALSAFCEGLNARLFKAGVHVLTIK
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCEEEEEEC
PGFVSTPMTAGLPLPGPLVASPEKVSRDIVRAIDKRKDTLYTPWFWAIIMLIIRSVPKPV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHH
FKRTSL
HHHCCC
>Mature Secondary Structure
MKNILIVGATSAIAIACARQWAAEGARFFLVARNGERLEQVADDLSARGAQLASRHQLDI
CCCEEEEECHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCH
TDLERHAAMFEQCLAALGTIDIVLVAPGTLPDQAACQADPAIAVREFNTNATAVIALLTR
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHH
IANALEAQRSGALAVISSVAADRGRPSNYLYGSAKAALSAFCEGLNARLFKAGVHVLTIK
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCEEEEEEC
PGFVSTPMTAGLPLPGPLVASPEKVSRDIVRAIDKRKDTLYTPWFWAIIMLIIRSVPKPV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHH
FKRTSL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406267 [H]