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The map label for this gene is hslU [H]

Identifier: 17544761

GI number: 17544761

Start: 45560

End: 46891

Strand: Reverse

Name: hslU [H]

Synonym: RSc0042

Alternate gene names: 17544761

Gene position: 46891-45560 (Counterclockwise)

Preceding gene: 17544762

Following gene: 17544757

Centisome position: 1.26

GC content: 65.84

Gene sequence:

>1332_bases
ATGCCCGAGACCATGACCCCGTCGGAAATCGTTTCCGAACTCGACAAGCACATCATCGGCCAGCAGAAGGCCAAGAAGGC
CGTGGCCGTGGCGCTGCGCAACCGCTGGCGCCGCCAGCAGGTGGCCGACCCGCTGCGCCAGGAGATCACGCCCAAGAACA
TCCTGATGATCGGCCCGACCGGCGTGGGCAAGACCGAGATCGCCCGGCGCCTGGCCAAGCTGGCCGACGCGCCCTTCATC
AAGATCGAGGCGACCAAGTTCACCGAGGTCGGCTATGTCGGCCGCGACGTCGACACCATCGTGCGCGACCTGGCCGAGAT
GGCCGTCAAGCAGACGCGCGAATCCGAGATGAAGAAGGTGCGCGCCAAGGCCGAGGACGCCGCCGAAGACCGCCTGCTGG
ACGTGCTGATCCCGCCGCCGCGCGACATCGGCTTCGCGCAGCCGGAGGAGAAGGACTCCAACGCGCGCCAGGTCTTCCGC
AAGAAGCTGCGCGAGGGCCAGCTCGACGACAAGGAGATCGAGCTCGAGGTCGCGGCCGGCATGCCCGGCATGGACATCAT
GGGCCCGCCGGGCATGGAAGAGATGACCGAGCAGATCCGCTCGATGTTCGCGGGCCTGGGCCAGGGCAAGAAGCACCGCC
GCAAGATGAAGGTGCACGAGGCCTTCAAGCTGCTGGTGGAGGAAGAGGCCGGCAAGCTCGTCAACGAAGAGGAGCTCAAG
CACAAGGCCATCGCCAATGTCGAGCAGAACGGCATCGTGTTCCTCGACGAGATCGACAAGATCACCAGCCGCAGCGAACA
CGGCGGCGGCGAAGTGTCGCGCCAGGGCGTGCAGCGCGACCTGCTGCCGCTGGTGGAGGGCACCACCGTGAGCACCAAGT
ACGGGATGATCAAGACCGACCACATCCTGTTCATCGCCTCGGGCGCGTTCCAGCTGTCCAAGCCGAGCGACCTGATCCCC
GAACTGCAGGGCCGCTTCCCGATCCGGGTGGAGCTCGATTCGCTGTCGGTGGATGACTTCCAGGCCATCCTGACGCAGAC
CGACGCGAGCCTCACCAAGCAGTACCAGGCGCTGATGAAGACCGAAGACGTCGAGCTCGTGTTCGCCGACGACGGCATCC
GCCGCCTGGCGGAGATCGCGTTCTCGGTCAACGAGAAGGTCGAGAACATCGGCGCGCGCCGCCTGTACACGGTGATGGAG
CGCCTGCTCGAAGACCTGTCGTTCCACGCGCACAAGTCGTCGGGCGAGACGGTGACCATCGACGCGGCCTATGTCGACAG
CCGCCTGAACGAGCTGGCCGGCAGCGAAGACCTGTCGCGCTACGTGCTGTAG

Upstream 100 bases:

>100_bases
CTGAGGATCGCCGGCGAGCTCTGCATCTACACCAACACCAATTTCGTGATCGAGACGCTGGAATAAGCCCGGCTCGACCG
CACGCATCGACAGAACATCC

Downstream 100 bases:

>100_bases
GGTCAGGCCCCGCGCCGCCGCGTCACGCACAACGGGCCGCATCGGTGACGATGCGGCCCGTTGTCGTATCGGATGCAATC
AAGGCGATCCATATCGCGCA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFI
KIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFR
KKLREGQLDDKEIELEVAAGMPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELK
HKAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFQLSKPSDLIP
ELQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMKTEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVME
RLLEDLSFHAHKSSGETVTIDAAYVDSRLNELAGSEDLSRYVL

Sequences:

>Translated_443_residues
MPETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFI
KIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFR
KKLREGQLDDKEIELEVAAGMPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELK
HKAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFQLSKPSDLIP
ELQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMKTEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVME
RLLEDLSFHAHKSSGETVTIDAAYVDSRLNELAGSEDLSRYVL
>Mature_442_residues
PETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFRK
KLREGQLDDKEIELEVAAGMPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELKH
KAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFQLSKPSDLIPE
LQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMKTEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVMER
LLEDLSFHAHKSSGETVTIDAAYVDSRLNELAGSEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=440, Percent_Identity=66.1363636363636, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=49, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648291, Length=257, Percent_Identity=29.9610894941634, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648289, Length=257, Percent_Identity=29.9610894941634, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49573; Mature: 49441

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPT
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKV
CCCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFRKKLREGQLDDKEIELEVAAG
HHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
MPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELK
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
HKAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTD
HHHHHCCCCCCEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFQLSKPSDLIPELQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMK
CEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
TEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHAHKSSGETVTI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DAAYVDSRLNELAGSEDLSRYVL
EHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure 
PETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPT
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKV
CCCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFRKKLREGQLDDKEIELEVAAG
HHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECC
MPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELK
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
HKAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTD
HHHHHCCCCCCEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIASGAFQLSKPSDLIPELQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMK
CEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
TEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHAHKSSGETVTI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DAAYVDSRLNELAGSEDLSRYVL
EHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA