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The map label for this gene is mdmC [H]

Identifier: 17232671

GI number: 17232671

Start: 6176622

End: 6177284

Strand: Reverse

Name: mdmC [H]

Synonym: all5179

Alternate gene names: 17232671

Gene position: 6177284-6176622 (Counterclockwise)

Preceding gene: 17232676

Following gene: 17232669

Centisome position: 96.31

GC content: 43.14

Gene sequence:

>663_bases
ATGACGACTCGCACTCTGGGAATCACCCCAAATTTATATGATTATTTACTATCTGTTTCTTTGCGGGAACCGGAAATACT
CGCTCAACTACGACAAGAAACAGCCTTGCAACCTATGGGAAGAATGCAAATTGCCCCAGAACAGGGACAATTTATGGCGT
TATTAGTACAATTGCTGGGGGCAAAAAAAACTCTAGAAGTGGGGGTATTTACAGGCTACAGTTCCTTGATTGTGGCACTA
GCTCTACCTGCGGAAGGAAAACTGGTAGCCTGCGATATTAATGAAGAGTTTACCGCGATCGCTCAACGTTATTGGCAAAA
AGCCGGAGTAGACCACAAAATTGACCTCTATCTCGCTCCAGCCTTGGAAACATTAGATAAGCTACTAGTAGCAGGTGAAG
CCGAAACCTTTGATTTTGCCTTTATTGACGCAGATAAGAGCAACTATGACAATTATTATGAGCGATCGCTGCAATTAATT
CGTTCAGGAGGTGTGATAGCGATCGATAATGTTCTCTGGTCTGGTAAAGTTGCCGATCCTGAAATTCAAGATAATCGCAC
CCAAAAAATCCGCGCCTTCAACCACAAGCTATTACAAGACCAGCGCATCACCTTGAGTTTAATTCCCATCGGCGACGGAT
TAACTTTAGTACGGAAAAATTAA

Upstream 100 bases:

>100_bases
TATTGAGTATATTCATCTTATATTCAAGTAAATGAAAAGTGACTCTTCTACGTTAGCTACGTAAATTTACTATTTAATCG
CAAATTTACAAATTAATCTT

Downstream 100 bases:

>100_bases
TTGTATGTTTTGTTAACAGTTGACGGTTAAATGTCAACCATCAACTGTCAATTAGGCCAAATTCTCTCAACAACTGACAA
CTGACTAATGACCCTTAAGG

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTTRTLGITPNLYDYLLSVSLREPEILAQLRQETALQPMGRMQIAPEQGQFMALLVQLLGAKKTLEVGVFTGYSSLIVAL
ALPAEGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAPALETLDKLLVAGEAETFDFAFIDADKSNYDNYYERSLQLI
RSGGVIAIDNVLWSGKVADPEIQDNRTQKIRAFNHKLLQDQRITLSLIPIGDGLTLVRKN

Sequences:

>Translated_220_residues
MTTRTLGITPNLYDYLLSVSLREPEILAQLRQETALQPMGRMQIAPEQGQFMALLVQLLGAKKTLEVGVFTGYSSLIVAL
ALPAEGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAPALETLDKLLVAGEAETFDFAFIDADKSNYDNYYERSLQLI
RSGGVIAIDNVLWSGKVADPEIQDNRTQKIRAFNHKLLQDQRITLSLIPIGDGLTLVRKN
>Mature_219_residues
TTRTLGITPNLYDYLLSVSLREPEILAQLRQETALQPMGRMQIAPEQGQFMALLVQLLGAKKTLEVGVFTGYSSLIVALA
LPAEGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAPALETLDKLLVAGEAETFDFAFIDADKSNYDNYYERSLQLIR
SGGVIAIDNVLWSGKVADPEIQDNRTQKIRAFNHKLLQDQRITLSLIPIGDGLTLVRKN

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=209, Percent_Identity=49.7607655502392, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17565612, Length=203, Percent_Identity=42.3645320197044, Blast_Score=150, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI72001127, Length=203, Percent_Identity=39.4088669950739, Blast_Score=133, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI72001028, Length=209, Percent_Identity=38.2775119617225, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25148771, Length=216, Percent_Identity=36.5740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71991493, Length=214, Percent_Identity=32.2429906542056, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24541; Mature: 24409

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTLGITPNLYDYLLSVSLREPEILAQLRQETALQPMGRMQIAPEQGQFMALLVQLLG
CCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHC
AKKTLEVGVFTGYSSLIVALALPAEGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAP
CCCEEEEEEECCHHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECH
ALETLDKLLVAGEAETFDFAFIDADKSNYDNYYERSLQLIRSGGVIAIDNVLWSGKVADP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECEEECCCCCCC
EIQDNRTQKIRAFNHKLLQDQRITLSLIPIGDGLTLVRKN
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECC
>Mature Secondary Structure 
TTRTLGITPNLYDYLLSVSLREPEILAQLRQETALQPMGRMQIAPEQGQFMALLVQLLG
CCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHC
AKKTLEVGVFTGYSSLIVALALPAEGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAP
CCCEEEEEEECCHHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEECH
ALETLDKLLVAGEAETFDFAFIDADKSNYDNYYERSLQLIRSGGVIAIDNVLWSGKVADP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECEEECCCCCCC
EIQDNRTQKIRAFNHKLLQDQRITLSLIPIGDGLTLVRKN
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]