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The map label for this gene is 17232387

Identifier: 17232387

GI number: 17232387

Start: 5834400

End: 5835818

Strand: Reverse

Name: 17232387

Synonym: all4895

Alternate gene names: NA

Gene position: 5835818-5834400 (Counterclockwise)

Preceding gene: 17232388

Following gene: 17232386

Centisome position: 90.99

GC content: 42.71

Gene sequence:

>1419_bases
ATGCAGATAGTTGATAAAAGGTCAAATAAGAAAGCCTGGGCAAGTGCATTAACTGAACCAGCAAAAGAATTTCCGCTTAC
TCAGTTAACCATTATCTCTGGTAACATCCCTGAAGGATTACGGGGTACACTCTACCGCAACGGACCTGCACGGTTAGAAC
GGGGAGGGATGCTTGCAGGACACTGGTTTGATGGCGATGGAGCAATTTTGGCTGTCAATTTTACCGATGGAGGTGTTCAT
GCAACTTACCGCTATGTACAGACTGTTGGCTATCAAGTGGAAAACACCGCCGATAAATTTCTGTACGGCAACTATGGGAT
GACTGCACCAGGCCCCGTTTGGAATCAATGGCGCAAACCAATTAAAAATGCTGCCAATACTTCAGTCCTAGCATTACCAG
ATAAACTTTTGGCATTGTGGGAAGGTGGAAGACCTTACGCTTTAGATTTACAGACTTTAGAAACCTGGGGCGAAGATAAT
TTAGGTGGCTTAACTAATGGATTAACTTATTCTGCCCACTATAAGCAAGACCCCCAGACCAAAGAAATTTTTAATTTTGG
TATTAGCTTGGGGTTAAATGCCAAGTTGAATGTTTACAAAAGTGACTCTACAGGTAAAATTATCCAAAAATCTGCATACT
CCCTAGATGGTCTCCCACTCATACATGATTTTGTTTTAGCAGGAAAGTATTTAATATTTTTTATTTCCCCTGTGCGGTTG
AATATGTTGCCTGTATTGTTGGGGACTAGCAACTATAGTGATTCTATGCAGTGGCGACCAGAATTAGGGACTCAGATTTT
AGTTATTGACCGTGAAAGTTTATCTTTAGTGAGTCGAGGGGAAACAGAGCCTTGGTATCAGTGGCATTTTGCTAACGGTT
ATGTAGATGCTAGTGGTGCAGTCATTGTGGATATTGCCCGTTACAAAGATTTTCAAACTAACCAATATCTCAAAGAAGTA
GCTACTGGTCAGACTCACACACCTGCTCCAAGTACACTGTCACGGGTCAATTTACATCCCCAATCTGGTAAAGTAGCCGC
AATTGAACAACTGTTAGATAGACATTGTGAATTTCCTCATGTGCCACGGCAAAACGTCGGTCAAGCATCTCGATATACCT
ATATGTCAGGATTCCGTCAAGGCACAGATATCAGCCAAGAACTATTAAACACGATCGCCTGCTTTGACCACAAGACACAA
ACCTTCATCGAAGCCTACCCAGGAGAAAACTGCTATCCTTCCGAACCCATACTTGCGGACAATTGGGTGTTAACAGTGGT
GTACGACGGCAATTCTCACAGTAGTCAAGTTTGGATATATGATAGCGATCGCCTCCATGAAGAACCAATCTGCAAACTAG
AATTACCCAAAGTCATCCCCCACAGTTTCCACGGGACATGGAAATCAGAGAAGAGATAA

Upstream 100 bases:

>100_bases
CGAGCAAATCAGGCAATGCTTGAGGCCAAGCGAACAAAAAAGAATCAGGTTGTTGCATACAGAAACGCCGATAATTAAAT
CTCTTAAGTTAGCAACTTAT

Downstream 100 bases:

>100_bases
GCTTGAGTAAGCTTCAAAATAGTTTTGGCTCACTCAAATTAAGTACATCTCTAAAGATAGATACAATTCTTCATGAAAAA
GTTTACTTTTGTATCTAGAT

Product: hypothetical protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MQIVDKRSNKKAWASALTEPAKEFPLTQLTIISGNIPEGLRGTLYRNGPARLERGGMLAGHWFDGDGAILAVNFTDGGVH
ATYRYVQTVGYQVENTADKFLYGNYGMTAPGPVWNQWRKPIKNAANTSVLALPDKLLALWEGGRPYALDLQTLETWGEDN
LGGLTNGLTYSAHYKQDPQTKEIFNFGISLGLNAKLNVYKSDSTGKIIQKSAYSLDGLPLIHDFVLAGKYLIFFISPVRL
NMLPVLLGTSNYSDSMQWRPELGTQILVIDRESLSLVSRGETEPWYQWHFANGYVDASGAVIVDIARYKDFQTNQYLKEV
ATGQTHTPAPSTLSRVNLHPQSGKVAAIEQLLDRHCEFPHVPRQNVGQASRYTYMSGFRQGTDISQELLNTIACFDHKTQ
TFIEAYPGENCYPSEPILADNWVLTVVYDGNSHSSQVWIYDSDRLHEEPICKLELPKVIPHSFHGTWKSEKR

Sequences:

>Translated_472_residues
MQIVDKRSNKKAWASALTEPAKEFPLTQLTIISGNIPEGLRGTLYRNGPARLERGGMLAGHWFDGDGAILAVNFTDGGVH
ATYRYVQTVGYQVENTADKFLYGNYGMTAPGPVWNQWRKPIKNAANTSVLALPDKLLALWEGGRPYALDLQTLETWGEDN
LGGLTNGLTYSAHYKQDPQTKEIFNFGISLGLNAKLNVYKSDSTGKIIQKSAYSLDGLPLIHDFVLAGKYLIFFISPVRL
NMLPVLLGTSNYSDSMQWRPELGTQILVIDRESLSLVSRGETEPWYQWHFANGYVDASGAVIVDIARYKDFQTNQYLKEV
ATGQTHTPAPSTLSRVNLHPQSGKVAAIEQLLDRHCEFPHVPRQNVGQASRYTYMSGFRQGTDISQELLNTIACFDHKTQ
TFIEAYPGENCYPSEPILADNWVLTVVYDGNSHSSQVWIYDSDRLHEEPICKLELPKVIPHSFHGTWKSEKR
>Mature_472_residues
MQIVDKRSNKKAWASALTEPAKEFPLTQLTIISGNIPEGLRGTLYRNGPARLERGGMLAGHWFDGDGAILAVNFTDGGVH
ATYRYVQTVGYQVENTADKFLYGNYGMTAPGPVWNQWRKPIKNAANTSVLALPDKLLALWEGGRPYALDLQTLETWGEDN
LGGLTNGLTYSAHYKQDPQTKEIFNFGISLGLNAKLNVYKSDSTGKIIQKSAYSLDGLPLIHDFVLAGKYLIFFISPVRL
NMLPVLLGTSNYSDSMQWRPELGTQILVIDRESLSLVSRGETEPWYQWHFANGYVDASGAVIVDIARYKDFQTNQYLKEV
ATGQTHTPAPSTLSRVNLHPQSGKVAAIEQLLDRHCEFPHVPRQNVGQASRYTYMSGFRQGTDISQELLNTIACFDHKTQ
TFIEAYPGENCYPSEPILADNWVLTVVYDGNSHSSQVWIYDSDRLHEEPICKLELPKVIPHSFHGTWKSEKR

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=452, Percent_Identity=22.3451327433628, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32564756, Length=308, Percent_Identity=26.2987012987013, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71998242, Length=307, Percent_Identity=25.7328990228013, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 52894; Mature: 52894

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVDKRSNKKAWASALTEPAKEFPLTQLTIISGNIPEGLRGTLYRNGPARLERGGMLAG
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCHHHCCCEEEE
HWFDGDGAILAVNFTDGGVHATYRYVQTVGYQVENTADKFLYGNYGMTAPGPVWNQWRKP
EEECCCCCEEEEEECCCCCHHHHHHHHHHCEEECCCCCCEEECCCCCCCCCCCHHHHHHH
IKNAANTSVLALPDKLLALWEGGRPYALDLQTLETWGEDNLGGLTNGLTYSAHYKQDPQT
HHHCCCCEEEECCHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCCH
KEIFNFGISLGLNAKLNVYKSDSTGKIIQKSAYSLDGLPLIHDFVLAGKYLIFFISPVRL
HHHHHHCCEECCCCEEEEEECCCCCCHHHHHCCCCCCCHHHHHHHHHCCEEEEEECCHHH
NMLPVLLGTSNYSDSMQWRPELGTQILVIDRESLSLVSRGETEPWYQWHFANGYVDASGA
CEEEEEEECCCCCCCCEECCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEECCEEECCCC
VIVDIARYKDFQTNQYLKEVATGQTHTPAPSTLSRVNLHPQSGKVAAIEQLLDRHCEFPH
EEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCCC
VPRQNVGQASRYTYMSGFRQGTDISQELLNTIACFDHKTQTFIEAYPGENCYPSEPILAD
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCEEEC
NWVLTVVYDGNSHSSQVWIYDSDRLHEEPICKLELPKVIPHSFHGTWKSEKR
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQIVDKRSNKKAWASALTEPAKEFPLTQLTIISGNIPEGLRGTLYRNGPARLERGGMLAG
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCHHHCCCEEEE
HWFDGDGAILAVNFTDGGVHATYRYVQTVGYQVENTADKFLYGNYGMTAPGPVWNQWRKP
EEECCCCCEEEEEECCCCCHHHHHHHHHHCEEECCCCCCEEECCCCCCCCCCCHHHHHHH
IKNAANTSVLALPDKLLALWEGGRPYALDLQTLETWGEDNLGGLTNGLTYSAHYKQDPQT
HHHCCCCEEEECCHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCCH
KEIFNFGISLGLNAKLNVYKSDSTGKIIQKSAYSLDGLPLIHDFVLAGKYLIFFISPVRL
HHHHHHCCEECCCCEEEEEECCCCCCHHHHHCCCCCCCHHHHHHHHHCCEEEEEECCHHH
NMLPVLLGTSNYSDSMQWRPELGTQILVIDRESLSLVSRGETEPWYQWHFANGYVDASGA
CEEEEEEECCCCCCCCEECCCCCCEEEEEECCCHHHHHCCCCCCCEEEEEECCEEECCCC
VIVDIARYKDFQTNQYLKEVATGQTHTPAPSTLSRVNLHPQSGKVAAIEQLLDRHCEFPH
EEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCCC
VPRQNVGQASRYTYMSGFRQGTDISQELLNTIACFDHKTQTFIEAYPGENCYPSEPILAD
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCCCCCEEEC
NWVLTVVYDGNSHSSQVWIYDSDRLHEEPICKLELPKVIPHSFHGTWKSEKR
CEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]