Click here to switch to the map view.

The map label for this gene is pheS [H]

Identifier: 17232337

GI number: 17232337

Start: 5771825

End: 5772817

Strand: Reverse

Name: pheS [H]

Synonym: all4845

Alternate gene names: 17232337

Gene position: 5772817-5771825 (Counterclockwise)

Preceding gene: 17232347

Following gene: 17232336

Centisome position: 90.01

GC content: 48.44

Gene sequence:

>993_bases
ATGACTAGCAACTTAGAAGCTCAACTTTTAGCACTGCGGCAGGAAGGAGAACAGGCGATCGCCGCCGCCGATACCCTCGA
ACGTCTGGAAGAACTCAGAGTTAGTTATCTGGGCAAGAAAGGGCAATTGGGGGCTTTGTTGCGGAGTATGGGGCAGATGA
GTGCGGAGGAAAGACCGAAAATTGGAGCGATCGCCAATACGGTTAAGGAAGCCCTACAAGCTAGTTTAGACAAGCAACGG
GAATCTTTAGAATCTGCCCAAATTCAGGCACAGTTAGACGCGGAAACGCTTGATGTCACTATGCCTGGTATTTACAAGCC
TCAAGGACGTATTCACCCCCTAAATGGCATTATTGACCGGGCGCTAGATGTTTTTGTGGGCTTGGGCTACACGGTGGCGC
AAGGGTTGGAAATGGAGACGGATTACTACAATTTTGAGGCGCTCAACACCCCACCAGACCACCCTGCCCGTGATATGCAG
GATACTTTCTACCTCCCAGACGGTAATCTCCTGCGTACTCACACCTCATCGGTGCAAATTCGTTATATGGAAAAAGAGGA
ACCACCAATTCACATTGTGGCTCCTGGGCGAGTTTATCGGCGAGATAATGTAGATGCCACCCACTCGGCAGTTTTCCATC
AAATCGAACTGTTAGCCATTGATGAGGGACTAACTTTTACCGACCTCAAAGGCACTATTAAGGTGTTTTTGCAAGCTATG
TTTGGTGATTTGCCAATTCGTTTCCGCGCCAGTTACTTCCCCTTTACCGAACCCTCGGCTGAGGTAGATTTGCAGTGGAA
TGGGCGCTGGTTGGAAGTCATGGGTTGCGGTATGGTCGATCCCAATGTGATGAAATCTGTAGGTTATAACCCAGAAATTT
ACACTGGCTTTGCGGCTGGTTTTGGTGTAGAACGTTTCGCAATGGTGCTACACCAAATCGATGATATTCGTCGTTTATAT
GCTAGTGACTTACGGTTTTTGCGTCAGTTCTGA

Upstream 100 bases:

>100_bases
TCATTAATGCCACATTGCTAATGTTAATTGTCCTTTGTCAGTTGTTTATTTTTTGCTACTGACCACCGACCACTGACCAC
TGACCACTGACTAATAAATA

Downstream 100 bases:

>100_bases
AAAACTCAGAAAAGAGCATTCGTATGGTGGGCATTGCCCACCACTGTTACTGTGTAAATCTCACAAAATATGTATTTTAT
ATAGTATTAGCTAACAGCAA

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTSNLEAQLLALRQEGEQAIAAADTLERLEELRVSYLGKKGQLGALLRSMGQMSAEERPKIGAIANTVKEALQASLDKQR
ESLESAQIQAQLDAETLDVTMPGIYKPQGRIHPLNGIIDRALDVFVGLGYTVAQGLEMETDYYNFEALNTPPDHPARDMQ
DTFYLPDGNLLRTHTSSVQIRYMEKEEPPIHIVAPGRVYRRDNVDATHSAVFHQIELLAIDEGLTFTDLKGTIKVFLQAM
FGDLPIRFRASYFPFTEPSAEVDLQWNGRWLEVMGCGMVDPNVMKSVGYNPEIYTGFAAGFGVERFAMVLHQIDDIRRLY
ASDLRFLRQF

Sequences:

>Translated_330_residues
MTSNLEAQLLALRQEGEQAIAAADTLERLEELRVSYLGKKGQLGALLRSMGQMSAEERPKIGAIANTVKEALQASLDKQR
ESLESAQIQAQLDAETLDVTMPGIYKPQGRIHPLNGIIDRALDVFVGLGYTVAQGLEMETDYYNFEALNTPPDHPARDMQ
DTFYLPDGNLLRTHTSSVQIRYMEKEEPPIHIVAPGRVYRRDNVDATHSAVFHQIELLAIDEGLTFTDLKGTIKVFLQAM
FGDLPIRFRASYFPFTEPSAEVDLQWNGRWLEVMGCGMVDPNVMKSVGYNPEIYTGFAAGFGVERFAMVLHQIDDIRRLY
ASDLRFLRQF
>Mature_329_residues
TSNLEAQLLALRQEGEQAIAAADTLERLEELRVSYLGKKGQLGALLRSMGQMSAEERPKIGAIANTVKEALQASLDKQRE
SLESAQIQAQLDAETLDVTMPGIYKPQGRIHPLNGIIDRALDVFVGLGYTVAQGLEMETDYYNFEALNTPPDHPARDMQD
TFYLPDGNLLRTHTSSVQIRYMEKEEPPIHIVAPGRVYRRDNVDATHSAVFHQIELLAIDEGLTFTDLKGTIKVFLQAMF
GDLPIRFRASYFPFTEPSAEVDLQWNGRWLEVMGCGMVDPNVMKSVGYNPEIYTGFAAGFGVERFAMVLHQIDDIRRLYA
SDLRFLRQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI5729820, Length=227, Percent_Identity=36.1233480176211, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4758340, Length=269, Percent_Identity=32.3420074349442, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1788007, Length=326, Percent_Identity=50.6134969325153, Blast_Score=333, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI32566635, Length=233, Percent_Identity=37.3390557939914, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17508957, Length=268, Percent_Identity=28.3582089552239, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32563657, Length=268, Percent_Identity=28.3582089552239, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321087, Length=264, Percent_Identity=30.6818181818182, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6325304, Length=88, Percent_Identity=45.4545454545455, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137424, Length=278, Percent_Identity=30.5755395683453, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18858079, Length=272, Percent_Identity=29.0441176470588, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 37120; Mature: 36989

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNLEAQLLALRQEGEQAIAAADTLERLEELRVSYLGKKGQLGALLRSMGQMSAEERPK
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCC
IGAIANTVKEALQASLDKQRESLESAQIQAQLDAETLDVTMPGIYKPQGRIHPLNGIIDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCEECHHHHHHH
ALDVFVGLGYTVAQGLEMETDYYNFEALNTPPDHPARDMQDTFYLPDGNLLRTHTSSVQI
HHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEECCCCCEEEEECCCEEE
RYMEKEEPPIHIVAPGRVYRRDNVDATHSAVFHQIELLAIDEGLTFTDLKGTIKVFLQAM
EEEECCCCCEEEECCCCEEECCCCCHHHHHHHHHEEEEEECCCCEEEHHHHHHHHHHHHH
FGDLPIRFRASYFPFTEPSAEVDLQWNGRWLEVMGCGMVDPNVMKSVGYNPEIYTGFAAG
HCCCCEEEEECCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHCCCCCCEEEHHHHH
FGVERFAMVLHQIDDIRRLYASDLRFLRQF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSNLEAQLLALRQEGEQAIAAADTLERLEELRVSYLGKKGQLGALLRSMGQMSAEERPK
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHCCCC
IGAIANTVKEALQASLDKQRESLESAQIQAQLDAETLDVTMPGIYKPQGRIHPLNGIIDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCEECHHHHHHH
ALDVFVGLGYTVAQGLEMETDYYNFEALNTPPDHPARDMQDTFYLPDGNLLRTHTSSVQI
HHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEECCCCCEEEEECCCEEE
RYMEKEEPPIHIVAPGRVYRRDNVDATHSAVFHQIELLAIDEGLTFTDLKGTIKVFLQAM
EEEECCCCCEEEECCCCEEECCCCCHHHHHHHHHEEEEEECCCCEEEHHHHHHHHHHHHH
FGDLPIRFRASYFPFTEPSAEVDLQWNGRWLEVMGCGMVDPNVMKSVGYNPEIYTGFAAG
HCCCCEEEEECCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHCCCCCCEEEHHHHH
FGVERFAMVLHQIDDIRRLYASDLRFLRQF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA