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The map label for this gene is sppA [H]

Identifier: 17232082

GI number: 17232082

Start: 5486507

End: 5488336

Strand: Reverse

Name: sppA [H]

Synonym: all4590

Alternate gene names: 17232082

Gene position: 5488336-5486507 (Counterclockwise)

Preceding gene: 17232083

Following gene: 17232073

Centisome position: 85.57

GC content: 42.68

Gene sequence:

>1830_bases
ATGAGTAACTTCTTTAAACAAACTCTTGCTAGCTTACTAGGTACATTATTAGGACTGTTTCTGTTCGCTGGTGCAGGTAC
TACAGGACTTTTATTATTATTGTTTGCTGCTGCTAGTTCCAGCAATACCGGCCCAGTAGTTAAAGATAAATCAGTAGTGG
TGTTCGACTTGTCCATGAACATCACCGACAGAGAACCAAGTGCTGGTGAAGAGCTACAAAATAGATTTTCCGGCGTTACA
CAAGAACGGATGACACTCCGTAATGTTATCGATAGTTTAGAAAAAGCACAACGAGATAAACGCATCGTTGCTATTTACCT
AGATGGTAGTCGTGGAGGCAATAACCTGGGTTTTGCGTCGTTGAAAGAAATCCGCAAAGCTCTAGAAGAATTCCGTAAAT
CTGGGAAAAAGGTAATCGCCTATGGTGTGGCTTGGGACGAGAAGGAATATTACCTCAGTTCGGTAGCTGATACTATCGCC
CTTAATCCTTTGGGTGGACTAGAAATCAATGGTTTGAGTAGCCAACCAATGTTCTTAGCCGGAGCTTTGCAAAAGTACGG
TATTGGCGTTCAGGTTGTACGAGCCGGAAAATTTAAGGGAGCAGTTGAACCGTTCTTGTTAGATAAACTGAGTCCAGAAA
ACCGCGAACAAACTCAAAAATTATTGGACGATGTTTGGGGTGAATGGCGTACCACCGTTGGCAATAGCCGGAAAATTAAC
CCACAAAAACTGCAAGCGATCGCCGATAATCAATCTTTATTGGAAGCAACGGAAGCTAAGACTAATGGCTTAGTCGATCA
AGTAGCGTACAACGATCAGGTAGTTGCTGACCTCAAGAAATTAACAGGTAGCAATAAAAAGGATAATACATTTACTCAAA
TTAGCCTGCGCCGATATGCTCAAGTACCTGGACAGTCTTTAGGCTTAGAAAAAAATTCTAAAAATAAGATTGCCGTAGTT
TATGCCGAAGGCGATATTGTCGATGGTAAAGGCGATGATGGGCAAATCGGAGGCGATCGCTTTGCCCGCATCTTTAATAA
AATCAGACAAGATGAAAATGTCAAAGCAGTTGTCTTACGCATCAATAGTCCTGGTGGTAGCGCTACAGCATCAGAAGTAA
TGCAGCGAGAAATACGCTTGACTCGTGAAAGCAAACCCGTTGTTGTATCTATGGGTGATTATGCCGCTTCTGGTGGTTAC
TGGATAGCCACCGACTCCAACCGAATTTTTGCCGAACCTAATACAATCACCGGTTCCATCGGTGTATTTGGCGTACTATT
TAACGGGCAGAAGCTAGCAAACGATAATGGTATCACCTGGGATGCTGTCAAAACGGCACGTTATGCGGATTCCCAAACCG
TCGCTCGTCCCAAATCACCCCAAGAGATAGCGATTTACCAGCGCAGTGTTGACCGCATTTACAATATGTTTGTCAACAAA
GTTGCTCAAGGTCGCAAGTTACCCACACAAAAAGTAGCCGAAATCGCTCAAGGTAGAGTTTGGTCTGGTGTAACTGCAAA
ACAAATTGGTTTGGTTGATGAAATCGGTGGTTTAAACGCCGCCATAGAATACGCAGCTAAAGCAGCGAAACTAGGTAAAG
ATTGGCAATTAAGAGAATATCCCAGAGAAAGCTCATTTGAAGAGCGCTTTTTTGGCGGGGTAGTCGAGGAAATTAGTACT
ACTTTGGGAATTAAGAAGTTGGACGTTAAACCAAATGACCCATTAACAGTACAAATCCAAAAAATCCAACAGGAAATCTC
TATTTTACAGACTATGAACGACCCACAAGGCGTTTATGCGCGGTTACCAATTAACTTAAAAATAGAGTAA

Upstream 100 bases:

>100_bases
GTAGTTTACAACGCCTACAATAAATGAATAGGTAGAAATGGTTAGGCATGATTGGCTAATCACTAATGACTAAATAACTA
AACTAAATAACTAATAACTA

Downstream 100 bases:

>100_bases
CTGTACAGATTAACTACAAAGTCTCATATTCCCTAAAATATCTTAAAGTCTGCCCTTTAAGATAAATTGAAGTGAATTAG
AAATCCTTGGATTAAAAACC

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTGPVVKDKSVVVFDLSMNITDREPSAGEELQNRFSGVT
QERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVAWDEKEYYLSSVADTIA
LNPLGGLEINGLSSQPMFLAGALQKYGIGVQVVRAGKFKGAVEPFLLDKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
PQKLQAIADNQSLLEATEAKTNGLVDQVAYNDQVVADLKKLTGSNKKDNTFTQISLRRYAQVPGQSLGLEKNSKNKIAVV
YAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGY
WIATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
VAQGRKLPTQKVAEIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEIST
TLGIKKLDVKPNDPLTVQIQKIQQEISILQTMNDPQGVYARLPINLKIE

Sequences:

>Translated_609_residues
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTGPVVKDKSVVVFDLSMNITDREPSAGEELQNRFSGVT
QERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVAWDEKEYYLSSVADTIA
LNPLGGLEINGLSSQPMFLAGALQKYGIGVQVVRAGKFKGAVEPFLLDKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
PQKLQAIADNQSLLEATEAKTNGLVDQVAYNDQVVADLKKLTGSNKKDNTFTQISLRRYAQVPGQSLGLEKNSKNKIAVV
YAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGY
WIATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
VAQGRKLPTQKVAEIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEIST
TLGIKKLDVKPNDPLTVQIQKIQQEISILQTMNDPQGVYARLPINLKIE
>Mature_608_residues
SNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTGPVVKDKSVVVFDLSMNITDREPSAGEELQNRFSGVTQ
ERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFASLKEIRKALEEFRKSGKKVIAYGVAWDEKEYYLSSVADTIAL
NPLGGLEINGLSSQPMFLAGALQKYGIGVQVVRAGKFKGAVEPFLLDKLSPENREQTQKLLDDVWGEWRTTVGNSRKINP
QKLQAIADNQSLLEATEAKTNGLVDQVAYNDQVVADLKKLTGSNKKDNTFTQISLRRYAQVPGQSLGLEKNSKNKIAVVY
AEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLRINSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYW
IATDSNRIFAEPNTITGSIGVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNKV
AQGRKLPTQKVAEIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREYPRESSFEERFFGGVVEEISTT
LGIKKLDVKPNDPLTVQIQKIQQEISILQTMNDPQGVYARLPINLKIE

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=568, Percent_Identity=35.0352112676056, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1787527, Length=167, Percent_Identity=28.1437125748503, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 66715; Mature: 66584

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTGPVVKDKSVVVFDLSMN
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEEEC
ITDREPSAGEELQNRFSGVTQERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFAS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHH
LKEIRKALEEFRKSGKKVIAYGVAWDEKEYYLSSVADTIALNPLGGLEINGLSSQPMFLA
HHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHEECCCCCEEECCCCCCCHHHH
GALQKYGIGVQVVRAGKFKGAVEPFLLDKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
HHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PQKLQAIADNQSLLEATEAKTNGLVDQVAYNDQVVADLKKLTGSNKKDNTFTQISLRRYA
HHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QVPGQSLGLEKNSKNKIAVVYAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLR
HCCCCCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
INSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYWIATDSNRIFAEPNTITGSI
EECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCEEEECCCCEEECC
GVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
EEEEEEECCCEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAQGRKLPTQKVAEIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREY
HHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHCC
PRESSFEERFFGGVVEEISTTLGIKKLDVKPNDPLTVQIQKIQQEISILQTMNDPQGVYA
CCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEE
RLPINLKIE
EECEEEEEC
>Mature Secondary Structure 
SNFFKQTLASLLGTLLGLFLFAGAGTTGLLLLLFAAASSSNTGPVVKDKSVVVFDLSMN
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEEEC
ITDREPSAGEELQNRFSGVTQERMTLRNVIDSLEKAQRDKRIVAIYLDGSRGGNNLGFAS
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHH
LKEIRKALEEFRKSGKKVIAYGVAWDEKEYYLSSVADTIALNPLGGLEINGLSSQPMFLA
HHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHEECCCCCEEECCCCCCCHHHH
GALQKYGIGVQVVRAGKFKGAVEPFLLDKLSPENREQTQKLLDDVWGEWRTTVGNSRKIN
HHHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PQKLQAIADNQSLLEATEAKTNGLVDQVAYNDQVVADLKKLTGSNKKDNTFTQISLRRYA
HHHHHHHHCCHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QVPGQSLGLEKNSKNKIAVVYAEGDIVDGKGDDGQIGGDRFARIFNKIRQDENVKAVVLR
HCCCCCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
INSPGGSATASEVMQREIRLTRESKPVVVSMGDYAASGGYWIATDSNRIFAEPNTITGSI
EECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCEECCCCEEEEECCCEEEECCCCEEECC
GVFGVLFNGQKLANDNGITWDAVKTARYADSQTVARPKSPQEIAIYQRSVDRIYNMFVNK
EEEEEEECCCEECCCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAQGRKLPTQKVAEIAQGRVWSGVTAKQIGLVDEIGGLNAAIEYAAKAAKLGKDWQLREY
HHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCHHCC
PRESSFEERFFGGVVEEISTTLGIKKLDVKPNDPLTVQIQKIQQEISILQTMNDPQGVYA
CCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEE
RLPINLKIE
EECEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]