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The map label for this gene is strD [H]

Identifier: 17231983

GI number: 17231983

Start: 5377539

End: 5378615

Strand: Direct

Name: strD [H]

Synonym: alr4491

Alternate gene names: 17231983

Gene position: 5377539-5378615 (Clockwise)

Preceding gene: 17231982

Following gene: 17231984

Centisome position: 83.84

GC content: 40.67

Gene sequence:

>1077_bases
ATGAAAGCACTAATTCTCTCTGGCGGTAGAGGTACACGTCTACGTCCACTCACCTATACTGGAGCAAAGCAACTTGTCCC
AGTTGCGAACAAGCCTATTTTATGGTACGGGATTGAAGAGATGGTCGCGGCTGGTATTACTGATATCGGTATAATTATCA
GCCCAGAAACAGGGGCAGAAGTACAAAGTAAAACTGGAGATGGAAAACTTTTTGGAGCGAACATCACCTATATTTTACAA
GAACAGCCTGCCGGCCTAGCTCATGCCGTTACTGTTGCTCGTCCCTTCTTAAAAGATTCACCTTTTGTCATGTACTTGGG
TGATAACCTAATTCAACAAGGCGACTTAAGCAACTTTTTACAAAAGTTTATTCAAGAACAACCTGATGCTCTAATTCTCT
TGCGTGAGGTTGTCAACCCTAGCGCCTTTGGTGTAGCTAAGGTAGATGATACGGGGCGGGTACTACAATTAGTCGAAAAA
CCCAAAGTTCCTCCATCCAATCTAGCTCTAGTAGGCGTTTATTTCTTTTCCCCGATTATTCATGATTCTATTGCTCGTAT
CCAGCCTTCAAGCAGAGGAGAACTGGAAATTACTGATGCTATTCAACGCTTAATAGACGATAAAAGACAAGTATTAGCTT
GTAATTTATATGGTTGGTGGTTAGACACCGGTAAAAAAGATGATTTATTAGAAGCTAATCGCTTAATTTTAGATACCTGT
TTAACAACGTCTAACTTAGGGGAAGTGGATGCTAAAAGTCAAATCATTGGACGAGTTCAAATCGGAGTCAATTCCCAGAT
CATCAATTGTACAATTCGTGGCCCCGTGGTTATTGGCAATAATTGTTATTTAGAAAATTGCTTTATTGGCCCTTATAGCA
GCATCGCCAACAATACAACACTCATCGACTCAGATTTAGAACATAGCGTAATTTTAGAAGGTGCTAAAATATCCGGAATT
GATCAGCGAATCATTGATAGTGTAATTGGACAACGAGCGCAACTAACAATTGCCCCCCGTCGCCCAAAAGCCTTACGCTT
TTTGATTGGTGATGATTGTCAAATTGAACTGACATAA

Upstream 100 bases:

>100_bases
CTTGTGAGAAGATGTCACAAGTTCTGGGAACTGCTCCCCCTCATTGGCAACAAAGACTGCGGTTGATGCTGCAAGACTGG
CTCTCCAAATATTCTTGATT

Downstream 100 bases:

>100_bases
CCCCTAATAGAGTTAGGGCAAAAATAAAGCTACGTTAAGCAAGACAAGGTTTTTACATCGGCTTGTAGTAGGTTTCAACT
TGCGATATTCTCCTACGTGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQKFIQEQPDALILLREVVNPSAFGVAKVDDTGRVLQLVEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSSRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGNNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT

Sequences:

>Translated_358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQKFIQEQPDALILLREVVNPSAFGVAKVDDTGRVLQLVEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSSRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGNNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
>Mature_358_residues
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAEVQSKTGDGKLFGANITYILQ
EQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFLQKFIQEQPDALILLREVVNPSAFGVAKVDDTGRVLQLVEK
PKVPPSNLALVGVYFFSPIIHDSIARIQPSSRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGNNCYLENCFIGPYSSIANNTTLIDSDLEHSVILEGAKISGI
DQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=350, Percent_Identity=29.4285714285714, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI11761619, Length=327, Percent_Identity=29.9694189602446, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=37.9746835443038, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=36.4406779661017, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787488, Length=270, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788355, Length=274, Percent_Identity=27.3722627737226, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789837, Length=197, Percent_Identity=29.4416243654822, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=339, Percent_Identity=30.3834808259587, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320148, Length=347, Percent_Identity=29.3948126801153, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355443, Length=338, Percent_Identity=28.4023668639053, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24644084, Length=338, Percent_Identity=28.4023668639053, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39073; Mature: 39073

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAE
CCEEEEECCCCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
VQSKTGDGKLFGANITYILQEQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFL
CCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHH
QKFIQEQPDALILLREVVNPSAFGVAKVDDTGRVLQLVEKPKVPPSNLALVGVYFFSPII
HHHHHHCCCCEEEEHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
HDSIARIQPSSRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHHHEEEHH
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGNNCYLENCFIGPYSSIANNTT
HCCCCCCCCCCHHHEEEEEEECCCCEEEEEEEECCEEECCCEEEEEEECCCHHHHCCCCE
LIDSDLEHSVILEGAKISGIDQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
EEECCCCCEEEEECCEECCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEC
>Mature Secondary Structure
MKALILSGGRGTRLRPLTYTGAKQLVPVANKPILWYGIEEMVAAGITDIGIIISPETGAE
CCEEEEECCCCCEEEEEEECCCCCEEECCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
VQSKTGDGKLFGANITYILQEQPAGLAHAVTVARPFLKDSPFVMYLGDNLIQQGDLSNFL
CCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHH
QKFIQEQPDALILLREVVNPSAFGVAKVDDTGRVLQLVEKPKVPPSNLALVGVYFFSPII
HHHHHHCCCCEEEEHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHH
HDSIARIQPSSRGELEITDAIQRLIDDKRQVLACNLYGWWLDTGKKDDLLEANRLILDTC
HHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCHHHHHHHEEEHH
LTTSNLGEVDAKSQIIGRVQIGVNSQIINCTIRGPVVIGNNCYLENCFIGPYSSIANNTT
HCCCCCCCCCCHHHEEEEEEECCCCEEEEEEEECCEEECCCEEEEEEECCCHHHHCCCCE
LIDSDLEHSVILEGAKISGIDQRIIDSVIGQRAQLTIAPRRPKALRFLIGDDCQIELT
EEECCCCCEEEEECCEECCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]