Click here to switch to the map view.

The map label for this gene is mre11 [H]

Identifier: 17231955

GI number: 17231955

Start: 5348101

End: 5349342

Strand: Reverse

Name: mre11 [H]

Synonym: all4463

Alternate gene names: 17231955

Gene position: 5349342-5348101 (Counterclockwise)

Preceding gene: 17231956

Following gene: 17231954

Centisome position: 83.4

GC content: 44.36

Gene sequence:

>1242_bases
ATGATTAAAATCCTCCATCTCTCTGACATCCACATGGGAAGCGGTTTTTCTCACGGACGTATTAATAGCGCCACGGGATT
AAATACGCGATTGGAGGATTTTGTCAATACTTTATCTGTATGTATTGATCGGGCGTTAGGAGATGCTGTAGATTTGGTCA
TATTTGGTGGTGATGCGTTTCCTGATGCTACGCCGCCGCCGTATGTGCAAGAAGCATTTGCCAGTCAATTTCGTCGTCTT
GTGGATGCTCAAATTCCGACTGTGTTGTTGGTGGGAAACCATGACCAACATTCCCAAGGACAAGGAGGTGCTAGTTTAAA
TATTTACCGCACTTTGGGAGTGCCGGGGTTTGTGGTTGGTGATAGGTTAATGACTCATCATATCCAAACTCGTAACGGCA
AAGTGCAGGTGATTACTTTACCTTGGCTAACTCGTTCGACACTGATGACGCGTCAAGAAACAGAAGGTTTGGGGTTGGCT
GAAGTCAATCAACTATTAACAGAACGTCTGCAAGTGGTGATGGAAGGGGAAATTCGCCGTCTTGACCCTGATGTGCCAAC
TGTGCTTTTAGCTCATTTGATGGCTGATAATGCAACTTTGGGTGCTGAACGCTATTTGGCTGTGGGTAAAGGTTTTACTC
TACCTTTATCTTTGCTGACTCGTCCTTGCTTTGATTATGTGGCATTGGGACACGTCCACCGTCATCAAAATTTGAATAAA
TCTAATAACCCCCCAGTGATTTATCCGGGGAGTATTGAACGGGTAGATTTTAGCGAGGAGAAAGAGGATAAGGGTTATGT
AATGATCGAACTAGAACAGGGGAATGTAAATTGGGAGTTCTGTCCCTTACCTGTTCGGACTTTTCGCACCATAGAAGTGG
ATGTATCAAAGGCAGATGATCCACAAGCTGCTATTGTGAAGGCGATCGCTAAACATGATATTCAAGATGCTGTCATACGC
CTAATCTACAAGCTCCGTTCCGAACAGATGGATGTAATTGATAGCGCCTCCCTACATAACGCCTTGAGTTCTGCCCATAC
TTACACCATTCAAGCTGAATTATTAAGTCAGTTGGCTAGACCCCGCATTCCTGAACTAAGTGCTAGTAGCAGCATCGACC
CAATGGAAGCATTAAAAACTTACTTGCAGAATCGTGAAGACTTGAAAGACATATCAGCGTCCATGCTAGAAGCAGCAGGA
AAGTTGTTAGATGATGATGTCGAAGTGGTCATTGGTCAATAG

Upstream 100 bases:

>100_bases
CCATAGTTCAACGCAAAGATGTTAACTATTTAACAGTTAATGGTTCAAAGTTGAAAACAACTATTACTATTAACTATTGA
TTATTGACTATTAACTAATC

Downstream 100 bases:

>100_bases
TCATTGGTCAATGGTCAGTTGTCCGTAGTCCGTAGTCATTAGTTTTTGTTCTTTACTTCTCCTGCTTCCCTACGTCTTCC
TAGTCCCCAATCCCCGTAAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAQIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELEQGNVNWEFCPLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVIR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAG
KLLDDDVEVVIGQ

Sequences:

>Translated_413_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAQIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELEQGNVNWEFCPLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVIR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAG
KLLDDDVEVVIGQ
>Mature_413_residues
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAFPDATPPPYVQEAFASQFRRL
VDAQIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVGDRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLA
EVNQLLTERLQVVMEGEIRRLDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELEQGNVNWEFCPLPVRTFRTIEVDVSKADDPQAAIVKAIAKHDIQDAVIR
LIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLARPRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAG
KLLDDDVEVVIGQ

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 45611; Mature: 45611

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAF
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
PDATPPPYVQEAFASQFRRLVDAQIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVG
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEHH
DRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLAEVNQLLTERLQVVMEGEIRR
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHC
LDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
CCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELEQGNVNWEFCPLPVRTFRTIEVDVSKADD
CCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEEEEECCCCC
PQAAIVKAIAKHDIQDAVIRLIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
PRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAGKLLDDDVEVVIGQ
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MIKILHLSDIHMGSGFSHGRINSATGLNTRLEDFVNTLSVCIDRALGDAVDLVIFGGDAF
CEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
PDATPPPYVQEAFASQFRRLVDAQIPTVLLVGNHDQHSQGQGGASLNIYRTLGVPGFVVG
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEHH
DRLMTHHIQTRNGKVQVITLPWLTRSTLMTRQETEGLGLAEVNQLLTERLQVVMEGEIRR
HHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHC
LDPDVPTVLLAHLMADNATLGAERYLAVGKGFTLPLSLLTRPCFDYVALGHVHRHQNLNK
CCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SNNPPVIYPGSIERVDFSEEKEDKGYVMIELEQGNVNWEFCPLPVRTFRTIEVDVSKADD
CCCCCEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEEEEECCCCC
PQAAIVKAIAKHDIQDAVIRLIYKLRSEQMDVIDSASLHNALSSAHTYTIQAELLSQLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
PRIPELSASSSIDPMEALKTYLQNREDLKDISASMLEAAGKLLDDDVEVVIGQ
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]