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The map label for this gene is cbs [H]

Identifier: 17231908

GI number: 17231908

Start: 5294621

End: 5295595

Strand: Direct

Name: cbs [H]

Synonym: alr4416

Alternate gene names: 17231908

Gene position: 5294621-5295595 (Clockwise)

Preceding gene: 17231904

Following gene: 17231909

Centisome position: 82.55

GC content: 44.72

Gene sequence:

>975_bases
ATGGATATCAAAAATGGCTTTATAGGAACTGTTGGCAACACACCACTAATTCGTTTAAACAGTTTTAGTGAAGAAACAGG
ATGTGAAATTCTCGCTAAAGCAGAATTTCTCAATCCTGGTGGTTCAGTCAAAGACCGCGCCGCACTTTACATCATCCAAG
ATGCAGAAGAAAAAGGACTCCTCAAAGCAGGCGGAACTGTTGTAGAAGGAACTGCTGGTAATACTGGCATTGGATTAGCG
CATATTTGCAATGCCAAAGGCTACAAATGCCTGATAATTATTCCTAACACCCAATCACAGGAAAAGATTGATGCACTCAC
AGCTTTGGGTGCAGAAGTCCGTCCCGTTCCTGCTGTACCTTACAAAGACCCAAACAATTACGTCAAACTATCTGGGAGAA
TTGCTGCGGAGTTAGACAACGCAATTTGGGCAAATCAGTTTGATAATTTAGCTAACCGCCGCGCTCATTACGAGACTACC
GGCCCAGAAATCTGGACACAAACCGATGGTAAAGTTGATGCTTGGGTAGCTTCCACTGGTACTGGTGGCACATTTGCCGG
TGTAGCCATGTATCTGAAAAACCAAAATCCCGCCATTAAATGCGTAGTAGCTGACCCACTAGGTAGCGGACTATATAGTT
ACATCAAAACTGGTGACATCAAGATAGAAGGAAATTCTATCACCGAAGGTATTGGTAACAGCCGCGTCACAGCTAATATG
GAAGGCGCACCAACTGATGATGCCATCCAAATAGATGACCATGAAGCTTTGCGGGTAGTTTACCAACTGTTGCGGAAAGA
TGGTTTATTCATGGGTGGTTCGACAGGTATTAATGTTGCCGGTGCTGTAGCTTTGGCGAAGCAATTGGGGCCTGGTCACA
GGATTGTCACCATATTATGTGATAGTGGTTCCCGCTACCAATCGCGTATATTCAACCGTGATTGGCTTGCATCCAAAGGA
CTAACGGTAGATTAG

Upstream 100 bases:

>100_bases
GTTGGTCGGAGAGAATCACTGGACAACTTAGATTAACTGTATATCCTGCCACCGCTATAAGTCACAATTTTTATATGCAC
TCCACTCAAGTCAAGACACA

Downstream 100 bases:

>100_bases
TTATGAGTCATTAGTTAGGTTTCTGGGCGTTGCTGATTAAGGGATAAATTTTGTTGTGTGCATACCGCCACGGCGGAACT
TGCAGAGTAGATACAGAAAT

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDIKNGFIGTVGNTPLIRLNSFSEETGCEILAKAEFLNPGGSVKDRAALYIIQDAEEKGLLKAGGTVVEGTAGNTGIGLA
HICNAKGYKCLIIIPNTQSQEKIDALTALGAEVRPVPAVPYKDPNNYVKLSGRIAAELDNAIWANQFDNLANRRAHYETT
GPEIWTQTDGKVDAWVASTGTGGTFAGVAMYLKNQNPAIKCVVADPLGSGLYSYIKTGDIKIEGNSITEGIGNSRVTANM
EGAPTDDAIQIDDHEALRVVYQLLRKDGLFMGGSTGINVAGAVALAKQLGPGHRIVTILCDSGSRYQSRIFNRDWLASKG
LTVD

Sequences:

>Translated_324_residues
MDIKNGFIGTVGNTPLIRLNSFSEETGCEILAKAEFLNPGGSVKDRAALYIIQDAEEKGLLKAGGTVVEGTAGNTGIGLA
HICNAKGYKCLIIIPNTQSQEKIDALTALGAEVRPVPAVPYKDPNNYVKLSGRIAAELDNAIWANQFDNLANRRAHYETT
GPEIWTQTDGKVDAWVASTGTGGTFAGVAMYLKNQNPAIKCVVADPLGSGLYSYIKTGDIKIEGNSITEGIGNSRVTANM
EGAPTDDAIQIDDHEALRVVYQLLRKDGLFMGGSTGINVAGAVALAKQLGPGHRIVTILCDSGSRYQSRIFNRDWLASKG
LTVD
>Mature_324_residues
MDIKNGFIGTVGNTPLIRLNSFSEETGCEILAKAEFLNPGGSVKDRAALYIIQDAEEKGLLKAGGTVVEGTAGNTGIGLA
HICNAKGYKCLIIIPNTQSQEKIDALTALGAEVRPVPAVPYKDPNNYVKLSGRIAAELDNAIWANQFDNLANRRAHYETT
GPEIWTQTDGKVDAWVASTGTGGTFAGVAMYLKNQNPAIKCVVADPLGSGLYSYIKTGDIKIEGNSITEGIGNSRVTANM
EGAPTDDAIQIDDHEALRVVYQLLRKDGLFMGGSTGINVAGAVALAKQLGPGHRIVTILCDSGSRYQSRIFNRDWLASKG
LTVD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=318, Percent_Identity=39.937106918239, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI295821200, Length=318, Percent_Identity=39.937106918239, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557415, Length=318, Percent_Identity=39.937106918239, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=36.963696369637, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=37.3417721518987, Blast_Score=157, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=38.5113268608414, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=39.1304347826087, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=37.828947368421, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=37.5816993464052, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=37.5415282392027, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17534315, Length=331, Percent_Identity=32.3262839879154, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=32.7102803738318, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=34.8214285714286, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71996324, Length=327, Percent_Identity=26.2996941896024, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=44.4108761329305, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=35.5421686746988, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=37.888198757764, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=37.888198757764, Blast_Score=201, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34428; Mature: 34428

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKNGFIGTVGNTPLIRLNSFSEETGCEILAKAEFLNPGGSVKDRAALYIIQDAEEKGL
CCCCCCEEECCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCE
LKAGGTVVEGTAGNTGIGLAHICNAKGYKCLIIIPNTQSQEKIDALTALGAEVRPVPAVP
EECCCEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC
YKDPNNYVKLSGRIAAELDNAIWANQFDNLANRRAHYETTGPEIWTQTDGKVDAWVASTG
CCCCCCEEEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECC
TGGTFAGVAMYLKNQNPAIKCVVADPLGSGLYSYIKTGDIKIEGNSITEGIGNSRVTANM
CCCHHEEEEEEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEECCHHCCCCCCCEEEEEC
EGAPTDDAIQIDDHEALRVVYQLLRKDGLFMGGSTGINVAGAVALAKQLGPGHRIVTILC
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGSRYQSRIFNRDWLASKGLTVD
CCCCHHHHHHCCCCHHCCCCCCCC
>Mature Secondary Structure
MDIKNGFIGTVGNTPLIRLNSFSEETGCEILAKAEFLNPGGSVKDRAALYIIQDAEEKGL
CCCCCCEEECCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEECCCCCCE
LKAGGTVVEGTAGNTGIGLAHICNAKGYKCLIIIPNTQSQEKIDALTALGAEVRPVPAVP
EECCCEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC
YKDPNNYVKLSGRIAAELDNAIWANQFDNLANRRAHYETTGPEIWTQTDGKVDAWVASTG
CCCCCCEEEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECC
TGGTFAGVAMYLKNQNPAIKCVVADPLGSGLYSYIKTGDIKIEGNSITEGIGNSRVTANM
CCCHHEEEEEEEECCCCEEEEEEECCCCCHHHHHHCCCCEEEECCHHCCCCCCCEEEEEC
EGAPTDDAIQIDDHEALRVVYQLLRKDGLFMGGSTGINVAGAVALAKQLGPGHRIVTILC
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGSRYQSRIFNRDWLASKGLTVD
CCCCHHHHHHCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]