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The map label for this gene is hisB

Identifier: 17231882

GI number: 17231882

Start: 5263236

End: 5263865

Strand: Reverse

Name: hisB

Synonym: all4390

Alternate gene names: 17231882

Gene position: 5263865-5263236 (Counterclockwise)

Preceding gene: 17231883

Following gene: 17231881

Centisome position: 82.07

GC content: 43.97

Gene sequence:

>630_bases
ATGCAAATCAGCGATTATCCCCAACTTAATTTGTCCTCAGTTCCTCGGATTGCTTCAGTGCATCGCATCACTGGGGAAAC
AAATGTACAAGTTACTGTCAATTTGGATGGTACGGGAATTTGTAAGGCAGCTACTGGCATTCCCTTTTTAGATCATATGC
TGCATCAAATTTCCTCCCACGGCTTGATTGATTTGGATGTCCAAGCCAAAGGAGATTGGGAAATTGATGACCACCACACA
AATGAAGATGTGGGTATTACTTTAGGTCAAGCTTTGGCTAAGGCATTAGGCGACAGAAAAGGTATAGTCCGCTTTGGTAA
TTTCCTAGCACCTTTAGACGAAGCTTTAGTACAGGTAGCATTGGATTTTTCTGGTCGTCCTCACCTCAGCTATGGCTTAC
AAATTCCTACGGAACGTGTGGGAACTTATGACACCCAATTAGTTAGAGAATTTTTTGTGGCATTAGTCAACCATAGCCAA
ATGACTCTGCACATTCGCCAATTAGATGGCATTAATTCCCATCACATTATTGAGGCGACCTTCAAAGCCTTTGCCAGAGC
AGCCAGAATGGCTATAGAAGTCGATCCTCGCCGCGCTGGGACGATTCCTAGCTCTAAGGGGGTTTTGTAA

Upstream 100 bases:

>100_bases
GAGGAACAAACAAGGTGGAAAAAGAATGATTTTTTCACCACTTTTTCCTTATATGCCCAGTCCCCAATCCCCGATCCCCA
ATCCCTAATCCCTAGCCTCT

Downstream 100 bases:

>100_bases
ACAGCAGGGGGCAGGGAGCAGGGGCAGGGAGCAGAAATCCCCAATCCCCAGTCACCAGTCCCCAATCCCCAGTCCCCAAT
CCCCAAAATTCGCAACAATT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICKAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEVDPRRAGTIPSSKGVL

Sequences:

>Translated_209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICKAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEVDPRRAGTIPSSKGVL
>Mature_209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICKAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEVDPRRAGTIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=207, Percent_Identity=47.3429951690821, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=39.3518518518519, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_NOSS1 (Q05068)

Other databases:

- EMBL:   L10036
- EMBL:   BA000019
- PIR:   AF2354
- RefSeq:   NP_488430.1
- ProteinModelPortal:   Q05068
- SMR:   Q05068
- STRING:   Q05068
- GeneID:   1107991
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4390
- NMPDR:   fig|103690.1.peg.4697
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q05068
- ProtClustDB:   PRK00951
- BioCyc:   NSP103690:ALL4390-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22890; Mature: 22890

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICKAATGIPFLDHMLHQISSH
CCCCCCCCCCCCCCCCHHHHHEECCCCCEEEEEEECCCCEEHHHCCCHHHHHHHHHHHCC
GLIDLDVQAKGDWEIDDHHTNEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVA
CEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINSHHIIEAT
HCCCCCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
FKAFARAARMAIEVDPRRAGTIPSSKGVL
HHHHHHHHHHEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICKAATGIPFLDHMLHQISSH
CCCCCCCCCCCCCCCCHHHHHEECCCCCEEEEEEECCCCEEHHHCCCHHHHHHHHHHHCC
GLIDLDVQAKGDWEIDDHHTNEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVA
CEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINSHHIIEAT
HCCCCCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
FKAFARAARMAIEVDPRRAGTIPSSKGVL
HHHHHHHHHHEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8391534; 11759840