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The map label for this gene is dxr

Identifier: 17231843

GI number: 17231843

Start: 5214905

End: 5216104

Strand: Direct

Name: dxr

Synonym: alr4351

Alternate gene names: 17231843

Gene position: 5214905-5216104 (Clockwise)

Preceding gene: 17231839

Following gene: 17231844

Centisome position: 81.31

GC content: 45.08

Gene sequence:

>1200_bases
ATTGTGAAAAGTATTACTCTTGTTGGTTCCACTGGCTCAATTGGTACTCAGACTCTAGATATCGTGAGTCAGTACCCAGA
TCAGTTTCGGATTGTGGGGTTAGCGGCGGGAAGCAATGTAGAAATGTTGGCAGAACAAATTCGCCAATTCCGTCCCCAAA
TAGCAGCGATTTCTGCCGCCGAAAAATTGCCAGCACTCCAAGCAGCCATTAAAGACCTTGATCCCCAGCCGATTTTATTA
GGGGGCGAAGCCGGAGTGATCGAAGTTGCTCGTTATGGTGATGCTGAAACGGTGGTGACAGGTATTGTCGGTTGTGCTGG
GTTATTGCCAACCATCGCCGCTATAGAAGCTGGTAAAGATATCGCCTTAGCAAACAAAGAAACTCTCATCGCCGGCGGGC
CTGTAGTTTTACCCTTAGTAGAAAAGCACGGCGTTAAATTATTACCAGCCGACTCCGAACATTCTGCCATCTTCCAGTGC
CTCCAAGGTGTACCAAAAGGCGGCTTAAAGAAGATTTTACTCACAGCTTCCGGTGGTGCTTTTCGGGATTGGGATGTGGA
AAGATTAGCAGAAGTGACGGTGTCCGATGCCCTGAAACATCCTAACTGGTCAATGGGGCGAAAAATTACTGTAGACTCAG
CTACCTTAATGAACAAAGGCTTAGAAGTAATTGAGGCTCACTTTCTGTTTGGGTTAGATTATCAAGATATCGAAATTGTC
ATCCATCCCCAAAGTATTATTCATTCACTAATTGAGCTGCAAGATACCTCTGTTTTAGCCCAACTCGGCTGGCCGGATAT
GCGCTTACCTTTGCTATATGCTTTATCTTGGCCTGAACGCATCTACACAGACTGGGAACGCTTAAATTTAGTCAAAGCTG
GCAATCTCACCTTCCGTGAACCAGACCATCAAAAGTATCCTTGTATGCAGTTAGCTTATGCTGCTGGTAGGGCTGGTGGT
TCCATGCCGGCGGTGTTAAATGCCGCGAATGAACAGGTTGTGGCATTATTCCTGGACGAGAAAATCAAATTTTTAGATAT
TCCCCGTTGTATCGAATTAGTGTGCGATCGCCATCAAAACGATAACTGTGCCAATCCTTCTTTAGATGATATTTTGGCAG
CAGATCAATGGGCAAGACAAGAAGTTTTAACAGCTACTAAAAATTTAGCAAGCCAACCTCAGATAATTTCCGTCAACTAA

Upstream 100 bases:

>100_bases
ATACCCTTACACCCGGTCTCAACAAAAAATCTGGGTGCGTAAATCCTATTAATGAGTCCTCAGCAATTTATAGTGAGAGT
TGTCGGTAAATCCTGAAGCA

Downstream 100 bases:

>100_bases
GCGCTGAAATTGCAAATACTTAGTATCTTGATGTCTTACGTGAGAAAAATCTGAAACTACATAAGACATCAAGATACACG
GGCTTTTTATCTGTTTTGTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILL
GGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQC
LQGVPKGGLKKILLTASGGAFRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIV
IHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGG
SMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN

Sequences:

>Translated_399_residues
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILL
GGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQC
LQGVPKGGLKKILLTASGGAFRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIV
IHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGG
SMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
>Mature_399_residues
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILL
GGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQC
LQGVPKGGLKKILLTASGGAFRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIV
IHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGG
SMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=43.5, Blast_Score=315, Evalue=4e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_NOSS1 (Q8YP49)

Other databases:

- EMBL:   BA000019
- PIR:   AH2349
- RefSeq:   NP_488391.1
- ProteinModelPortal:   Q8YP49
- SMR:   Q8YP49
- STRING:   Q8YP49
- GeneID:   1107953
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr4351
- NMPDR:   fig|103690.1.peg.4658
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q8YP49
- ProtClustDB:   PRK05447
- BioCyc:   NSP103690:ALR4351-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43201; Mature: 43201

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 153-153 BINDING 177-177 BINDING 200-200 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAA
CCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHH
EKLPALQAAIKDLDPQPILLGGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKD
HHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
IALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLKKILLTASGGA
EEECCCCEEEECCCEEEEEHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCC
FRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIV
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFRE
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCHHHHCCHHHHEEEEECCEEECC
PDHQKYPCMQLAYAAGRAGGSMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQN
CCCCCCCHHHHHHHHCCCCCCCCHHEECCCCEEEEEEECCCCCEECCHHHHHHHHCCCCC
DNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAA
CCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHH
EKLPALQAAIKDLDPQPILLGGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKD
HHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
IALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLKKILLTASGGA
EEECCCCEEEECCCEEEEEHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCC
FRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIV
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEE
IHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFRE
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCHHHHCCHHHHEEEEECCEEECC
PDHQKYPCMQLAYAAGRAGGSMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQN
CCCCCCCHHHHHHHHCCCCCCCCHHEECCCCEEEEEEECCCCCEECCHHHHHHHHCCCCC
DNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840