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The map label for this gene is dapL2 [H]

Identifier: 17231819

GI number: 17231819

Start: 5178289

End: 5179461

Strand: Reverse

Name: dapL2 [H]

Synonym: all4327

Alternate gene names: 17231819

Gene position: 5179461-5178289 (Counterclockwise)

Preceding gene: 17231820

Following gene: 17231817

Centisome position: 80.76

GC content: 41.77

Gene sequence:

>1173_bases
ATGCAGTTTGCTAAACGTTTAGAAAAAATTCCTCCTTATTTGTTTGCTGAAATTAACCGTAAACGGGAAGCACTAATTGC
CAAAGGAGTTGACATTATTAATATAGGGGTAGGTGATCCTGATAAGCCAACTCCTGCTCATATTCTCCAGGCGATGCGTG
AGGCAATTGACGACGCTTCTAACCATAATTATCCACCTTATGAAGGTACACAAGAGTTTAGAGAAGCAGCTGTTGAGTGG
ATGGAACGTCGATTTGGGGTGATGGATTTAAACCCCAACACTGAAGTTGTGTCTTCTATTGGATCAAAAGAGGCTATACA
CAATACTTTTTTAGCTTTTGTGGAAGCAGGAGACTACACGTTAATACCAGACCCTGGTTATCCCGTATATAGAACTTCTA
CGATTTTTGCTGGGGGCGAAGCTTTCTCCATGCCTCTGAAAGCAGAAAATAAATTTTTACCCGATTTGGATTTAATCCCT
GAGGAAGTTGCCCGTAAAGCAAAAATGTTGTGGATTAATTATCCAAACAACCCTACTGGGGCTTTAGCAACATTAGAGTT
CTTTGAGGAATTAGTAGCTCTTTGTCAGCAGTACAGTATTTTGTTGTGCCATGATCATGCTTATTCAGAAATGGCGTATG
ATGGCTACAAACCACCGAGTGTCCTGCAAATTCCAGGTGCGAAGGATATTGCCATTGAGTTTCACAGTCTATCGAAGTCA
TATAATATGACAGGCTGGCGGATTGGATTTGCAGTTGGTAATGCCTATGCTATTAAAGGCTTGAGTCAAGTAAAAACGAA
CGTTGATTCTGGAGTATTTAAAGCAATTCAAAAAGCAGCGATCGCTGCTTATGCCACTGATGAAGTAGAATTACAAGCTG
TAATGTCAGTTTATCAAAGTCGCCGTGACATCATCGTTAAGGGATTGCAATCTTTAGGATGGCCTATCGAACCACCAAAA
GCCACTCTTTATGTTTGGGTTCCTGTACCGCCTGGATATACCTCTACTGAATTTACTACTTTGCTGTTAGATAAATGTGG
TATCGTCGTTCCCCCAGGGGTTGGTTATGGCGCGTCAGGCGAAGGTTATTTTAGAGTTGCCCTCACTATCTCTGATGAAC
GTTTACATGAAGCGATTCAACGGATGCAGGATGCGGGGATTCGATATGCTTAG

Upstream 100 bases:

>100_bases
TTTTAATAGCGAATAAACAAAGGGCTGCTGTGATTTATTTACCTAGTGTGGCGTAAACTGTGCTAGAGAGCATCCACTTT
TGCATTAGTTACAAGTTGCC

Downstream 100 bases:

>100_bases
TCATTAGTTTTTTCCTTTACTCCCTACTCCCCACACCTTCTTGATAAGCTTGCCAAAGTTGTTGAATAAACTGATGGAGT
TGCTGCTTGACTGCTAAGTC

Product: LL-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT 2; DAP-aminotransferase 2; LL-DAP-aminotransferase 2 [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDASNHNYPPYEGTQEFREAAVEW
MERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYTLIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIP
EEVARKAKMLWINYPNNPTGALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKS
YNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQSRRDIIVKGLQSLGWPIEPPK
ATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASGEGYFRVALTISDERLHEAIQRMQDAGIRYA

Sequences:

>Translated_390_residues
MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDASNHNYPPYEGTQEFREAAVEW
MERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYTLIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIP
EEVARKAKMLWINYPNNPTGALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKS
YNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQSRRDIIVKGLQSLGWPIEPPK
ATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASGEGYFRVALTISDERLHEAIQRMQDAGIRYA
>Mature_390_residues
MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDASNHNYPPYEGTQEFREAAVEW
MERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYTLIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIP
EEVARKAKMLWINYPNNPTGALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKS
YNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQSRRDIIVKGLQSLGWPIEPPK
ATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASGEGYFRVALTISDERLHEAIQRMQDAGIRYA

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=334, Percent_Identity=27.2455089820359, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI169881279, Length=334, Percent_Identity=27.2455089820359, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI56713256, Length=332, Percent_Identity=24.3975903614458, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI56713254, Length=332, Percent_Identity=24.3975903614458, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI169881281, Length=228, Percent_Identity=26.7543859649123, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4507369, Length=375, Percent_Identity=22.4, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1788722, Length=378, Percent_Identity=39.1534391534392, Blast_Score=311, Evalue=3e-86,
Organism=Escherichia coli, GI1786816, Length=329, Percent_Identity=24.3161094224924, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788627, Length=259, Percent_Identity=25.4826254826255, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17567663, Length=377, Percent_Identity=26.790450928382, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71994476, Length=271, Percent_Identity=25.4612546125461, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71994472, Length=271, Percent_Identity=25.4612546125461, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17567369, Length=264, Percent_Identity=23.4848484848485, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71981209, Length=400, Percent_Identity=23.75, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=391, Percent_Identity=21.7391304347826, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573069, Length=385, Percent_Identity=23.6363636363636, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646114, Length=385, Percent_Identity=23.6363636363636, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28573067, Length=385, Percent_Identity=23.6363636363636, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28573065, Length=385, Percent_Identity=23.6363636363636, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859735, Length=377, Percent_Identity=22.5464190981432, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43226; Mature: 43226

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDAS
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCC
NHNYPPYEGTQEFREAAVEWMERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYT
CCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCHHHHHHHHHHEEECCCEE
LIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIPEEVARKAKMLWINYPNNPTG
EECCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCH
ALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKS
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCCCEEECCCCCEEEEEEEHHCCC
YNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQS
CCCCEEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RRDIIVKGLQSLGWPIEPPKATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEECCCCCCCCCC
EGYFRVALTISDERLHEAIQRMQDAGIRYA
CCEEEEEEEECHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDAS
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCC
NHNYPPYEGTQEFREAAVEWMERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYT
CCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCHHHHHHHHHHEEECCCEE
LIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIPEEVARKAKMLWINYPNNPTG
EECCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCH
ALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKS
HHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCCCCEEECCCCCEEEEEEEHHCCC
YNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQS
CCCCEEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RRDIIVKGLQSLGWPIEPPKATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCEEECCCCCCCCCC
EGYFRVALTISDERLHEAIQRMQDAGIRYA
CCEEEEEEEECHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA