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The map label for this gene is fabF [H]

Identifier: 17231778

GI number: 17231778

Start: 5140377

End: 5141543

Strand: Reverse

Name: fabF [H]

Synonym: all4286

Alternate gene names: 17231778

Gene position: 5141543-5140377 (Counterclockwise)

Preceding gene: 17231779

Following gene: 17231777

Centisome position: 80.16

GC content: 44.3

Gene sequence:

>1167_bases
ATGATTGAAGTTGTCATTACTGGTATTGGGCTAGTTTCAGCCTTGGGTAAGAGCCTAGAGGAGAGTTGGCAAGGTTTAAT
TGCAGGCAAGTCTGGAATAAAATGGCATCAACCATTTCCAGAGTTACCACCTCTACCTTTAGGCTTAATTGGTGAAAAGC
CGACTAGTTTGCACAGCTTGACTCAGGTGGTGGTGGATGCGGCAATCAAAGATGCGGGGTTAGTACCACCTTTAACTGAT
TGTGCGCTAGTCATTGGTTCTAGTCGCGGTTATCAAGGATCGTGGGAAAAACTAGCACGGCAAATATATACTGGTGATGA
TTCTGCGGATGAGGCAGAAAAATTAGAGAATTGGTTAGATGTTTTACCCCACATGAATACGATCGCCGCAGCGCGACAAA
TTGGGGCGACAGGGGCAGTTATAGCACCGATGGCGGCTTGTGCTACCGGAATTTGGGCGATCGCTCAAGCCGCAATTCTT
ATCCAGACAGGGCAATATCAACGCGTCATTGCTGGAGCCACGGAAGCAGCAATTACACCCTTAACCTTGTCAGGGTTTCA
ACAAATGGGAGCTTTAGCCAAAACCGGAGCTTACCCCTTTGATTTACAGCGTGAAGGTTTAGTTTTAGGTGAAGGGGCTG
CTGTATTTGTCTTGGAATCCAGACAATTAGCAAAAAAACGTAAAGCCAAGATTTATGGTCAAATTTTGGGTTTTGGCTTG
ATAAATGATGCTTATCATAGTACTCAATTAGAGCCGGAGGGGAAGGGGGCGATCGCATCTATTCAGCAATGTTTAGCTCG
GAGTCAGCTAACATTGACTGATATCGATTACATTCATGCTCACGGTACAGCTACTCAGCTCAATGACAGAGTAGAAAGTC
AAGTAATCAAACATTTATTTCCCTCAAAAGTAGCAGTCAGTTCTACCAAAGGCAGTACAGGCCATACTTTAGGCGCATCA
GGCGCATTAGGAGTGGCTTTTTCACTTCTAGCTTTAGAGCAAAAAATAATACCTCCCTGTGTGGGATTCCAGGAACCAGA
ATTTGATTTGAATATAGTAAAAACAGCACAACACAGCCAAATTCAACAGGTGTTGTGTCTGAGTTTTGGTTTTGGTGGAC
AGAATGCAGCTATAGCTTTAGGAAGAGGGAATGATAATTGGGGTTAG

Upstream 100 bases:

>100_bases
CCTCAATAGGTTTGGGGATTAGGGATGGGGTACTAGTGATTGGGAATAGAGTAATCAGTGTCCTTTTCTTTATTTCCTCA
TCTCTAATCCAAAATCTCAC

Downstream 100 bases:

>100_bases
GGTCTAGAGTTTAGACAACAAGGAATTTCCCACAAAAATTTTGCCTTTTCTTCAGTCCCCAGTCCCTAATCCCCAATCCC
TACATTTCAGAAACGGATAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIEVVITGIGLVSALGKSLEESWQGLIAGKSGIKWHQPFPELPPLPLGLIGEKPTSLHSLTQVVVDAAIKDAGLVPPLTD
CALVIGSSRGYQGSWEKLARQIYTGDDSADEAEKLENWLDVLPHMNTIAAARQIGATGAVIAPMAACATGIWAIAQAAIL
IQTGQYQRVIAGATEAAITPLTLSGFQQMGALAKTGAYPFDLQREGLVLGEGAAVFVLESRQLAKKRKAKIYGQILGFGL
INDAYHSTQLEPEGKGAIASIQQCLARSQLTLTDIDYIHAHGTATQLNDRVESQVIKHLFPSKVAVSSTKGSTGHTLGAS
GALGVAFSLLALEQKIIPPCVGFQEPEFDLNIVKTAQHSQIQQVLCLSFGFGGQNAAIALGRGNDNWG

Sequences:

>Translated_388_residues
MIEVVITGIGLVSALGKSLEESWQGLIAGKSGIKWHQPFPELPPLPLGLIGEKPTSLHSLTQVVVDAAIKDAGLVPPLTD
CALVIGSSRGYQGSWEKLARQIYTGDDSADEAEKLENWLDVLPHMNTIAAARQIGATGAVIAPMAACATGIWAIAQAAIL
IQTGQYQRVIAGATEAAITPLTLSGFQQMGALAKTGAYPFDLQREGLVLGEGAAVFVLESRQLAKKRKAKIYGQILGFGL
INDAYHSTQLEPEGKGAIASIQQCLARSQLTLTDIDYIHAHGTATQLNDRVESQVIKHLFPSKVAVSSTKGSTGHTLGAS
GALGVAFSLLALEQKIIPPCVGFQEPEFDLNIVKTAQHSQIQQVLCLSFGFGGQNAAIALGRGNDNWG
>Mature_388_residues
MIEVVITGIGLVSALGKSLEESWQGLIAGKSGIKWHQPFPELPPLPLGLIGEKPTSLHSLTQVVVDAAIKDAGLVPPLTD
CALVIGSSRGYQGSWEKLARQIYTGDDSADEAEKLENWLDVLPHMNTIAAARQIGATGAVIAPMAACATGIWAIAQAAIL
IQTGQYQRVIAGATEAAITPLTLSGFQQMGALAKTGAYPFDLQREGLVLGEGAAVFVLESRQLAKKRKAKIYGQILGFGL
INDAYHSTQLEPEGKGAIASIQQCLARSQLTLTDIDYIHAHGTATQLNDRVESQVIKHLFPSKVAVSSTKGSTGHTLGAS
GALGVAFSLLALEQKIIPPCVGFQEPEFDLNIVKTAQHSQIQQVLCLSFGFGGQNAAIALGRGNDNWG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=249, Percent_Identity=42.9718875502008, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=44.2176870748299, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=25.1764705882353, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787337, Length=258, Percent_Identity=39.5348837209302, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=29.9043062200957, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71983541, Length=407, Percent_Identity=29.4840294840295, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=33.59375, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=29.1095890410959, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=249, Percent_Identity=24.8995983935743, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=29.2792792792793, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=33.4939759036145, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI19920632, Length=249, Percent_Identity=26.1044176706827, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330659, Length=249, Percent_Identity=26.1044176706827, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581345, Length=250, Percent_Identity=25.6, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 40933; Mature: 40933

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVVITGIGLVSALGKSLEESWQGLIAGKSGIKWHQPFPELPPLPLGLIGEKPTSLHSL
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TQVVVDAAIKDAGLVPPLTDCALVIGSSRGYQGSWEKLARQIYTGDDSADEAEKLENWLD
HHHHHHHHHHCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
VLPHMNTIAAARQIGATGAVIAPMAACATGIWAIAQAAILIQTGQYQRVIAGATEAAITP
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHCCHHHHCCC
LTLSGFQQMGALAKTGAYPFDLQREGLVLGEGAAVFVLESRQLAKKRKAKIYGQILGFGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHH
INDAYHSTQLEPEGKGAIASIQQCLARSQLTLTDIDYIHAHGTATQLNDRVESQVIKHLF
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHC
PSKVAVSSTKGSTGHTLGASGALGVAFSLLALEQKIIPPCVGFQEPEFDLNIVKTAQHSQ
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
IQQVLCLSFGFGGQNAAIALGRGNDNWG
HHHHHHHHCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MIEVVITGIGLVSALGKSLEESWQGLIAGKSGIKWHQPFPELPPLPLGLIGEKPTSLHSL
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
TQVVVDAAIKDAGLVPPLTDCALVIGSSRGYQGSWEKLARQIYTGDDSADEAEKLENWLD
HHHHHHHHHHCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
VLPHMNTIAAARQIGATGAVIAPMAACATGIWAIAQAAILIQTGQYQRVIAGATEAAITP
HHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHCCHHHHCCC
LTLSGFQQMGALAKTGAYPFDLQREGLVLGEGAAVFVLESRQLAKKRKAKIYGQILGFGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHH
INDAYHSTQLEPEGKGAIASIQQCLARSQLTLTDIDYIHAHGTATQLNDRVESQVIKHLF
HHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHC
PSKVAVSSTKGSTGHTLGASGALGVAFSLLALEQKIIPPCVGFQEPEFDLNIVKTAQHSQ
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
IQQVLCLSFGFGGQNAAIALGRGNDNWG
HHHHHHHHCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]