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The map label for this gene is thrA [H]

Identifier: 17231612

GI number: 17231612

Start: 4962715

End: 4964004

Strand: Reverse

Name: thrA [H]

Synonym: all4120

Alternate gene names: 17231612

Gene position: 4964004-4962715 (Counterclockwise)

Preceding gene: 17231613

Following gene: 17231610

Centisome position: 77.4

GC content: 46.51

Gene sequence:

>1290_bases
GTGGGTGTAAAGCTGGGAATCTTAGGATTAGGTACGGTAGGAACGGGAACGGTGCAACTGCTACAAGATACAGTTGGTCG
TCACCCTTTGCTGCAAGAAATAGAAATATATCGGGTGGGAGTACGATCGCTTGATAAATCCCGCGATGTACAATTACAGC
CGGAAGTTATAACTACAGATTTAGAGTCAATTGTCAATGACCCAGCAGTAGATATTGTTGTTGAGGTCATGGGGGGATTA
GAACCGGCGCGATCGCTCATTCTCCAAGCCATACATAATGGTAAGCACGTAGTCACAGCTAATAAAGCGGCGATCGCTCG
TTTCGGGGCAGAAATTTTTACGGCTGCTAATCAAGCCGGAGTTTATGTGATGCTGGAAGCCGCCGTTGGTGGTGGTATTC
CTGTAATTCAACCATTGAAGCAGGCTTTAAGTGTCAACAGACTGCATACTGTTACAGGCATTGTTAATGGTACTACTAAC
TACATCCTCACCCGGATGCAAACAGAGGGTAGCGAATTTGCTGATGTCTTAGCTGATGCCCAGCGCTTGGGTTACGCAGA
AGCCGACCCTACGGCGGATGTAGAGGGTTTAGATGCGGCAGATAAAATTGCTATTCTCGCGTCATTGGCTTTTGATGGGC
GAATTAACTTGCAGGATGTCTACTGTGAGGGGATTCGTCAAGTCAGTAAAACAGATATCGCCTATGCCGAAAAATTGGGA
TTTGTGATTAAATTACTAGCGATCGCTAAAAATCAGGCTCAAGATGCCACTAAACTATCGGTCAGAGTTCACCCCACCTT
CGTACCCAAAACACATCCCCTAGCTAGTATTAACGGCGTGTATAACGCCATTCTTGTAGAAGGAGAACCCATAGGTCAGG
TGATGTTTTTTGGCCCTGGTGCAGGTGCAGGAGCAACCGCCAGCGCCGTCACCTCGGATATATTGAGTTTGGTAGCAGCC
CTGAAGAGTAATACGACAGCCCCCAATCCCCTATTAACCTGTAGACACGAAGAATATAGCCAAGTTGCTCCCATTAGCGA
CCTTTTAACCAGATTTTACGCCCGATTCCTCACCAAAGACCAAGCTGGCGTCATTGGTCAATTAGGTACTTGCTTTGGAA
ATCATGGGGTGAGTATAGAATCAATTGTCCAAACTGGCTTTCAAGGGGAACTAGTAGAGATTGTAGTTGTGACGCACGAT
GTCAGAGAAGGTGAATTTCGCCAAGCCCTAGCAGAAATTCAAAATTTACCGGCGATTGATAGCATTCCTAGCATATTGCG
GGTGTTGTAG

Upstream 100 bases:

>100_bases
TATATAAATACCTGAGAAATGAGTTCTTAGTTCTGGGGATGATGACTCAGGACTCAGGACTCAGGACTCAGCACTTAAAA
CTAAATTTGGTACAAAGTTT

Downstream 100 bases:

>100_bases
GGAGTGGGACGAGAAAAAGCAGACAACTGACAACTTATACACACAGTGCAGTAAAAAAATGACCAAGCATAGTTTTGCTT
GGTCATTTCTCTTATAAAAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MGVKLGILGLGTVGTGTVQLLQDTVGRHPLLQEIEIYRVGVRSLDKSRDVQLQPEVITTDLESIVNDPAVDIVVEVMGGL
EPARSLILQAIHNGKHVVTANKAAIARFGAEIFTAANQAGVYVMLEAAVGGGIPVIQPLKQALSVNRLHTVTGIVNGTTN
YILTRMQTEGSEFADVLADAQRLGYAEADPTADVEGLDAADKIAILASLAFDGRINLQDVYCEGIRQVSKTDIAYAEKLG
FVIKLLAIAKNQAQDATKLSVRVHPTFVPKTHPLASINGVYNAILVEGEPIGQVMFFGPGAGAGATASAVTSDILSLVAA
LKSNTTAPNPLLTCRHEEYSQVAPISDLLTRFYARFLTKDQAGVIGQLGTCFGNHGVSIESIVQTGFQGELVEIVVVTHD
VREGEFRQALAEIQNLPAIDSIPSILRVL

Sequences:

>Translated_429_residues
MGVKLGILGLGTVGTGTVQLLQDTVGRHPLLQEIEIYRVGVRSLDKSRDVQLQPEVITTDLESIVNDPAVDIVVEVMGGL
EPARSLILQAIHNGKHVVTANKAAIARFGAEIFTAANQAGVYVMLEAAVGGGIPVIQPLKQALSVNRLHTVTGIVNGTTN
YILTRMQTEGSEFADVLADAQRLGYAEADPTADVEGLDAADKIAILASLAFDGRINLQDVYCEGIRQVSKTDIAYAEKLG
FVIKLLAIAKNQAQDATKLSVRVHPTFVPKTHPLASINGVYNAILVEGEPIGQVMFFGPGAGAGATASAVTSDILSLVAA
LKSNTTAPNPLLTCRHEEYSQVAPISDLLTRFYARFLTKDQAGVIGQLGTCFGNHGVSIESIVQTGFQGELVEIVVVTHD
VREGEFRQALAEIQNLPAIDSIPSILRVL
>Mature_428_residues
GVKLGILGLGTVGTGTVQLLQDTVGRHPLLQEIEIYRVGVRSLDKSRDVQLQPEVITTDLESIVNDPAVDIVVEVMGGLE
PARSLILQAIHNGKHVVTANKAAIARFGAEIFTAANQAGVYVMLEAAVGGGIPVIQPLKQALSVNRLHTVTGIVNGTTNY
ILTRMQTEGSEFADVLADAQRLGYAEADPTADVEGLDAADKIAILASLAFDGRINLQDVYCEGIRQVSKTDIAYAEKLGF
VIKLLAIAKNQAQDATKLSVRVHPTFVPKTHPLASINGVYNAILVEGEPIGQVMFFGPGAGAGATASAVTSDILSLVAAL
KSNTTAPNPLLTCRHEEYSQVAPISDLLTRFYARFLTKDQAGVIGQLGTCFGNHGVSIESIVQTGFQGELVEIVVVTHDV
REGEFRQALAEIQNLPAIDSIPSILRVL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=310, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786183, Length=248, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=228, Percent_Identity=29.3859649122807, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45558; Mature: 45427

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKLGILGLGTVGTGTVQLLQDTVGRHPLLQEIEIYRVGVRSLDKSRDVQLQPEVITTD
CCEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHH
LESIVNDPAVDIVVEVMGGLEPARSLILQAIHNGKHVVTANKAAIARFGAEIFTAANQAG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCC
VYVMLEAAVGGGIPVIQPLKQALSVNRLHTVTGIVNGTTNYILTRMQTEGSEFADVLADA
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHEEEEECCCCHHHHHHHHHH
QRLGYAEADPTADVEGLDAADKIAILASLAFDGRINLQDVYCEGIRQVSKTDIAYAEKLG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKNQAQDATKLSVRVHPTFVPKTHPLASINGVYNAILVEGEPIGQVMFFGPG
HHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCHHHCCCEEEEEECCCCCCEEEEECCC
AGAGATASAVTSDILSLVAALKSNTTAPNPLLTCRHEEYSQVAPISDLLTRFYARFLTKD
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHCCC
QAGVIGQLGTCFGNHGVSIESIVQTGFQGELVEIVVVTHDVREGEFRQALAEIQNLPAID
CCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHH
SIPSILRVL
HHHHHHHHC
>Mature Secondary Structure 
GVKLGILGLGTVGTGTVQLLQDTVGRHPLLQEIEIYRVGVRSLDKSRDVQLQPEVITTD
CEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHH
LESIVNDPAVDIVVEVMGGLEPARSLILQAIHNGKHVVTANKAAIARFGAEIFTAANQAG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCCC
VYVMLEAAVGGGIPVIQPLKQALSVNRLHTVTGIVNGTTNYILTRMQTEGSEFADVLADA
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHEEEEECCCCHHHHHHHHHH
QRLGYAEADPTADVEGLDAADKIAILASLAFDGRINLQDVYCEGIRQVSKTDIAYAEKLG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKNQAQDATKLSVRVHPTFVPKTHPLASINGVYNAILVEGEPIGQVMFFGPG
HHHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCHHHCCCEEEEEECCCCCCEEEEECCC
AGAGATASAVTSDILSLVAALKSNTTAPNPLLTCRHEEYSQVAPISDLLTRFYARFLTKD
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCHHHHHHHHHHHHHCCC
QAGVIGQLGTCFGNHGVSIESIVQTGFQGELVEIVVVTHDVREGEFRQALAEIQNLPAID
CCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCHH
SIPSILRVL
HHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]