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The map label for this gene is cya [H]

Identifier: 17231564

GI number: 17231564

Start: 4901476

End: 4902957

Strand: Direct

Name: cya [H]

Synonym: alr4072

Alternate gene names: 17231564

Gene position: 4901476-4902957 (Clockwise)

Preceding gene: 17231561

Following gene: 17231567

Centisome position: 76.42

GC content: 42.85

Gene sequence:

>1482_bases
GTGTATAACACCATTATCGGCACACCATTTAATGATCGGCTCGTTGGTACTATGGTTGACGATCTAATAGTTGCTTTGCA
AGGAGATGATCAAATCATTGGTAGTGCAGGCAATGATTTCATAGTTGGGGATATAGGAATTGATACTGTTGACTACAGTG
AATTAGGTCAAGCTGTTACTTTACAAGCTACGGGTATTGTTCAAAAAGGCAGAGCCGGAACAGACACACTCAATGGCATT
GAAACTATAATTGGTGCGAAAGGACAAGCCAATACAATAGATGCTTCCACCACCACAGGTTCTACTACATCAGTTAGCGT
TAATCTTTCCGCTAACAGTCTGATAGTGAATGGAGTTCCCACAACTAGCCCATTGAATTTTACAGTGCAGAGATTTGTAA
ATGTTATCGGTACTGCACAAAATGACAGCATCATTGGCGATAACAACAATAACCTGCTAATTGGTGGTCAAGGTAACGAC
GAAATTTTTGGACTCAACGGTAATGACACCGTGCAAGGTGGTGCTGGTGATGATGTGATAGGTGGAGGGAGTAGAAGTAG
TCTTGCGACTTCCCGATTAGGTGATGGTAACGATATCGTACAAGGCGAGGGTGGTAATGATGTCCTGATCGGCGGTACTG
GTAATGACACCATTGATGGTGGTGCTGACCTTGATACAGCTGACTATAGTAATGTAGGTACTGCGATCGCCTTACAAGCA
TCTGGTATTGTCAACAAAGGTGCAGCAGGTACAGATCAAATCCTCAACATTGAAACTATCATCGGTGCAACACGTCAAGC
CAACACCATTGATGGTTCTACCGGTACTAGTACAACCACGTCATTTAACGTCAATCTCTCTACTAATAGTCTCATCGTTA
ACGGTGTTCCAGTCTTAGGAACACTGAACTTTAATGTTCAAAATTTTGTTAACGTCACTGGTACTTCCCAAGTTGACACT
ATAGTTGGTAATAACCAAGGTAACTTATTGATTGGTGGTAGAGGCAATGATCAAATCTCTGGTCTTGGTGGTAAAGATAC
CATCATCGGCGTTGATCCTAACAGTCGCCAACCAGGTATTAATGAAGTAGACACCCTCACCGGAGGTGCAGATCCTGATA
AATTCGTCTTAGGAGATGCCACAAAGCCCTACTATGTAGGCGGTGGTGGTTTTGCAGGCTTGAATGACTTTGCCTTGATT
ACTGATTTTCAAACCGGTCAGGATCAAATCCAACTCAAAAAGCTAGACGGTTATATCTTCGGCAGTAATTATATTGCGAT
CGCCAGTCCATTCTCGTTAGACAGCAGTAAAGCCTTCGATGATTCCGTGTTAGTGGCGACTGCAAATCAGATTGTGAAAG
GCAATGGTGTCTACGATGCTTCTAGTCAGAGTGATTTGACATCCTCTTCTATATTTGCTCGTTTTGATATCATTTCCATC
TTTTCCACTAGCTACAGCGTCAGCGACATCCACTTTGTCTAG

Upstream 100 bases:

>100_bases
TTAATGAAACCGTATCAAATTGTTAACCTAATTCTGATATCTTAAAAAAGATTTACAAATATTTGCATTCCTCAACCGAA
TTTAAAGGAAAAATAGCGAC

Downstream 100 bases:

>100_bases
AAAGACAACAGACAAAAGAATTGTCATCATTACTAATTCGTAATTCGTAATTAACGTGCGCCTCCGTTGGAGGCGCACGT
TAATTAGAGGTGCAACATCA

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MYNTIIGTPFNDRLVGTMVDDLIVALQGDDQIIGSAGNDFIVGDIGIDTVDYSELGQAVTLQATGIVQKGRAGTDTLNGI
ETIIGAKGQANTIDASTTTGSTTSVSVNLSANSLIVNGVPTTSPLNFTVQRFVNVIGTAQNDSIIGDNNNNLLIGGQGND
EIFGLNGNDTVQGGAGDDVIGGGSRSSLATSRLGDGNDIVQGEGGNDVLIGGTGNDTIDGGADLDTADYSNVGTAIALQA
SGIVNKGAAGTDQILNIETIIGATRQANTIDGSTGTSTTTSFNVNLSTNSLIVNGVPVLGTLNFNVQNFVNVTGTSQVDT
IVGNNQGNLLIGGRGNDQISGLGGKDTIIGVDPNSRQPGINEVDTLTGGADPDKFVLGDATKPYYVGGGGFAGLNDFALI
TDFQTGQDQIQLKKLDGYIFGSNYIAIASPFSLDSSKAFDDSVLVATANQIVKGNGVYDASSQSDLTSSSIFARFDIISI
FSTSYSVSDIHFV

Sequences:

>Translated_493_residues
MYNTIIGTPFNDRLVGTMVDDLIVALQGDDQIIGSAGNDFIVGDIGIDTVDYSELGQAVTLQATGIVQKGRAGTDTLNGI
ETIIGAKGQANTIDASTTTGSTTSVSVNLSANSLIVNGVPTTSPLNFTVQRFVNVIGTAQNDSIIGDNNNNLLIGGQGND
EIFGLNGNDTVQGGAGDDVIGGGSRSSLATSRLGDGNDIVQGEGGNDVLIGGTGNDTIDGGADLDTADYSNVGTAIALQA
SGIVNKGAAGTDQILNIETIIGATRQANTIDGSTGTSTTTSFNVNLSTNSLIVNGVPVLGTLNFNVQNFVNVTGTSQVDT
IVGNNQGNLLIGGRGNDQISGLGGKDTIIGVDPNSRQPGINEVDTLTGGADPDKFVLGDATKPYYVGGGGFAGLNDFALI
TDFQTGQDQIQLKKLDGYIFGSNYIAIASPFSLDSSKAFDDSVLVATANQIVKGNGVYDASSQSDLTSSSIFARFDIISI
FSTSYSVSDIHFV
>Mature_493_residues
MYNTIIGTPFNDRLVGTMVDDLIVALQGDDQIIGSAGNDFIVGDIGIDTVDYSELGQAVTLQATGIVQKGRAGTDTLNGI
ETIIGAKGQANTIDASTTTGSTTSVSVNLSANSLIVNGVPTTSPLNFTVQRFVNVIGTAQNDSIIGDNNNNLLIGGQGND
EIFGLNGNDTVQGGAGDDVIGGGSRSSLATSRLGDGNDIVQGEGGNDVLIGGTGNDTIDGGADLDTADYSNVGTAIALQA
SGIVNKGAAGTDQILNIETIIGATRQANTIDGSTGTSTTTSFNVNLSTNSLIVNGVPVLGTLNFNVQNFVNVTGTSQVDT
IVGNNQGNLLIGGRGNDQISGLGGKDTIIGVDPNSRQPGINEVDTLTGGADPDKFVLGDATKPYYVGGGGFAGLNDFALI
TDFQTGQDQIQLKKLDGYIFGSNYIAIASPFSLDSSKAFDDSVLVATANQIVKGNGVYDASSQSDLTSSSIFARFDIISI
FSTSYSVSDIHFV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 50374; Mature: 50374

Theoretical pI: Translated: 3.73; Mature: 3.73

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNTIIGTPFNDRLVGTMVDDLIVALQGDDQIIGSAGNDFIVGDIGIDTVDYSELGQAVT
CCCCEECCCCCCCCHHHHHCEEEEEECCCCEEEECCCCEEEEEECCCCCCCHHHHCCEEE
LQATGIVQKGRAGTDTLNGIETIIGAKGQANTIDASTTTGSTTSVSVNLSANSLIVNGVP
EEEECEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCCEEEEECCC
TTSPLNFTVQRFVNVIGTAQNDSIIGDNNNNLLIGGQGNDEIFGLNGNDTVQGGAGDDVI
CCCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCEEEECCCCEECCCCCCCCC
GGGSRSSLATSRLGDGNDIVQGEGGNDVLIGGTGNDTIDGGADLDTADYSNVGTAIALQA
CCCCCCCHHHHCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEE
SGIVNKGAAGTDQILNIETIIGATRQANTIDGSTGTSTTTSFNVNLSTNSLIVNGVPVLG
CCCCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCEEE
TLNFNVQNFVNVTGTSQVDTIVGNNQGNLLIGGRGNDQISGLGGKDTIIGVDPNSRQPGI
EEECCHHHEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCC
NEVDTLTGGADPDKFVLGDATKPYYVGGGGFAGLNDFALITDFQTGQDQIQLKKLDGYIF
CHHHHCCCCCCCCCEEECCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCEEE
GSNYIAIASPFSLDSSKAFDDSVLVATANQIVKGNGVYDASSQSDLTSSSIFARFDIISI
CCCEEEEECCCCCCCCCCCCCEEEEEECCEEEECCCEECCCCCCCCCCCCEEEEEEEEEE
FSTSYSVSDIHFV
EECCCCCEEEEEC
>Mature Secondary Structure
MYNTIIGTPFNDRLVGTMVDDLIVALQGDDQIIGSAGNDFIVGDIGIDTVDYSELGQAVT
CCCCEECCCCCCCCHHHHHCEEEEEECCCCEEEECCCCEEEEEECCCCCCCHHHHCCEEE
LQATGIVQKGRAGTDTLNGIETIIGAKGQANTIDASTTTGSTTSVSVNLSANSLIVNGVP
EEEECEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCCEEEEECCC
TTSPLNFTVQRFVNVIGTAQNDSIIGDNNNNLLIGGQGNDEIFGLNGNDTVQGGAGDDVI
CCCCCCHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCCEEEECCCCEECCCCCCCCC
GGGSRSSLATSRLGDGNDIVQGEGGNDVLIGGTGNDTIDGGADLDTADYSNVGTAIALQA
CCCCCCCHHHHCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEE
SGIVNKGAAGTDQILNIETIIGATRQANTIDGSTGTSTTTSFNVNLSTNSLIVNGVPVLG
CCCCCCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCEEE
TLNFNVQNFVNVTGTSQVDTIVGNNQGNLLIGGRGNDQISGLGGKDTIIGVDPNSRQPGI
EEECCHHHEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCC
NEVDTLTGGADPDKFVLGDATKPYYVGGGGFAGLNDFALITDFQTGQDQIQLKKLDGYIF
CHHHHCCCCCCCCCEEECCCCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEEEECCEEE
GSNYIAIASPFSLDSSKAFDDSVLVATANQIVKGNGVYDASSQSDLTSSSIFARFDIISI
CCCEEEEECCCCCCCCCCCCCEEEEEECCEEEECCCEECCCCCCCCCCCCEEEEEEEEEE
FSTSYSVSDIHFV
EECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]