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The map label for this gene is serS [H]

Identifier: 17231468

GI number: 17231468

Start: 4790980

End: 4792260

Strand: Reverse

Name: serS [H]

Synonym: all3976

Alternate gene names: 17231468

Gene position: 4792260-4790980 (Counterclockwise)

Preceding gene: 17231469

Following gene: 17231467

Centisome position: 74.72

GC content: 42.7

Gene sequence:

>1281_bases
GTGCTGGATATTAAGCAAATAAGGGAAAATCCCCAACTCATTCAGGAACGGTTGAATAGCCGCAATGGTACTTATGACAT
TCAACCCATATTACAGTTAGATAAGCAACAACGGGAGTTGGAAGCGACCCGCAGTCAAATCCAAGCCCGGAGTAACGAAA
TTGGTAAAATTGTCGGACAGAAGATTAAATCGGGTATTAATCCTCAAGACCCAGAAATTCAAGCTTTGCGGGATGAGGGG
AACGCGATTAAAGCCCAATTGAGTGAACTAGAACCAAGAGAAAAAGAACTCAAAGCGGAAATTGAGCAACTTATACTCGC
ACTCCCTAATTTACCCAGTGACTCTACACCTATAGGTAAAGGTGAGGAAGAAAATGTAGAGGTAAGACTTTGGGGTGATG
AATATCTACCCCAGAATCCGAATATTATCCCCCATTGGGAAATCGGCGAAAAGCTGGGGATTCTCAATTTTGAACGTGCT
GTCAAAGTTGCCCAAAGTCGCTTTGTGAACTTGATAGGCGCTGGTGCAGCGTTGGAGCGGGCGTTAATTAACTTTATGCT
GAAGATGCAAACCGCAGCTGGCTATATAGAAGTTAGTCCACCCTTGTTAGTCAATACCGATTCTTTAACAGGAACAGGTC
AATTACCGAAGTTTGCAGAAGAAAGCTTTAAGTGTGCTGATGATGAATTGTGGTTAATTCCCACAGCAGAAGTTCCTGTT
ACTAACCTTTATCGCGGAGAAATCCTGGCGGCGGAAAATTTACCCATTTATCACTGTGCTTATACTCCCTGTTTTCGTCG
GGAAGCAGGAAGTTATGGACGAGATATGCGGGGTTTAATTCGCCTGCATCAATTCAATAAAGTAGAGTTGGTAAAAGTCG
TTCATCCCAGCACTTCTTTTGATGAATTAGAAAAATTGGTGGGGAATGCCGAAGCAATTTTACAGGCTTTAAAATTACCT
TACCGGGTGATTAATCTTTGTACTGGTGATTTAGGTTTTGGGGCAACGAAAACCTATGATTTAGAAGTATGGCTACCATC
TTCTGGTAAATATCGGGAAATTTCCAGTTGTTCTAATTGTTTTGATTTCCAAGCGCGGCGAGCCGATATTCGCTTTAAGG
AAGCAGGTAAGAAAGGTACACAGTTTGTCCATACCCTCAACGGTTCTGGCTTGGCTGTAGGGCGCACAATGGCAGCTATT
TTGGAAAATTATCAGCAACCAGATGGGACAATTTTGATACCGGAAGTATTGCAACCTTTCTTAGGGCGTGAAGTGTTGTA
A

Upstream 100 bases:

>100_bases
ACAAGATTTTTGTATTTGCCTTTCCTGGCATGGCAAGTCAAAATCAGTATATGCTGATGTGTTGGCAAGAAGATACTAGG
CGAAAGATTGAGAAAAATTT

Downstream 100 bases:

>100_bases
GACTGATACAAAGCACTCTCAAGTTTTCAGATTTGGCATAATTTCTTACGAAGAATCTCCATATAATCACTTCTCTAAGA
GTGGTTATATGGAGATATTG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDIKQIRENPQLIQERLNSRNGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NAIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKGEEENVEVRLWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKMQTAAGYIEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQPFLGREVL

Sequences:

>Translated_426_residues
MLDIKQIRENPQLIQERLNSRNGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NAIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKGEEENVEVRLWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKMQTAAGYIEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQPFLGREVL
>Mature_426_residues
MLDIKQIRENPQLIQERLNSRNGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NAIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKGEEENVEVRLWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKMQTAAGYIEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQPFLGREVL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=342, Percent_Identity=37.1345029239766, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI8923421, Length=442, Percent_Identity=33.2579185520362, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI225579074, Length=445, Percent_Identity=31.2359550561798, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=49.4226327944573, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539260, Length=471, Percent_Identity=30.7855626326964, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=322, Percent_Identity=28.8819875776398, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=34.3115124153499, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6321799, Length=429, Percent_Identity=28.6713286713287, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=31.0344827586207, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=29.4294294294294, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47676; Mature: 47676

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKQIRENPQLIQERLNSRNGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQ
CCCHHHHHCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIKSGINPQDPEIQALRDEGNAIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGK
HHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEEENVEVRLWGDEYLPQNPNIIPHWEIGEKLGILNFERAVKVAQSRFVNLIGAGAALER
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ALINFMLKMQTAAGYIEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
HHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCC
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSF
CCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCH
DELEKLVGNAEAILQALKLPYRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHH
FDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAILENYQQPDGTILIPEVLQPF
HHHHHHHCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHH
LGREVL
HCCCCC
>Mature Secondary Structure
MLDIKQIRENPQLIQERLNSRNGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQ
CCCHHHHHCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIKSGINPQDPEIQALRDEGNAIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGK
HHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GEEENVEVRLWGDEYLPQNPNIIPHWEIGEKLGILNFERAVKVAQSRFVNLIGAGAALER
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ALINFMLKMQTAAGYIEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
HHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCC
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSF
CCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCH
DELEKLVGNAEAILQALKLPYRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHH
FDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAILENYQQPDGTILIPEVLQPF
HHHHHHHCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHH
LGREVL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA