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The map label for this gene is argH [H]

Identifier: 17231379

GI number: 17231379

Start: 4687822

End: 4689207

Strand: Direct

Name: argH [H]

Synonym: alr3887

Alternate gene names: 17231379

Gene position: 4687822-4689207 (Clockwise)

Preceding gene: 17231378

Following gene: 17231382

Centisome position: 73.09

GC content: 44.52

Gene sequence:

>1386_bases
ATGACCGAAAAACAAACTTGGAGTCAGCGATTTGAATCTGCTCTACATCCAGCGATCGCTCTTTTTAATGCCAGTATAAG
TTTTGACATAGAATTAATAGAATACGACCTTACAGGCTCTCAAGCTCATGCCCAGATGTTGGCGCATACGGGGATTATTT
CGCCGGCAGAAGGAGAACAACTAGTTGCAGGTTTAGAACAAATTCGTGAAGAATATCGCCAGGGCAAATTTCAACCTGGT
ATCGATGCGGAAGATGTCCACTTTGCAGTTGAGCGACGGTTAACAGAAATTGTTGGAGATGTAGGTAAGAAATTACATAC
TGCGCGATCGCGTAATGATCAAGTCGGTACGGATACAAGACTTTACCTACGTGACCAAATTTTACAAATCAAAACCCAAT
TACGGGAATTTCAACGGGTCTTATTAGATATAGCTGAAAAAAACGTGGAAACTCTAATTCCTGGTTACACTCACCTACAA
CGCGCCCAGCCTGTGAGTTTAGCTCATCACTTGTTGGCTTACTTCCAAATGGCACAACGGGACTGGGAACGCTTAGGGGA
TGTTTATCGCCGGGTGAATATTTCGCCTTTGGGGTGTGGTGCTTTAGCTGGTACGACTTTTCCCATTGACCGCCACTACA
CAGCCGAATTGTTGCAGTTTGAGCGTATTTACGAGAATAGCTTGGATGGAGTGAGCGATCGCGATTTTGCCATTGAATTT
TTGTGTGCGGCTAGTCTGATTATGGTTCACCTCAGCCGTCTTTCTGAAGAAATTATTCTTTGGGCATCGGAAGAATTTCG
CTTCGTCATCCTCAAAGATAGTTGTGCAACAGGTTCCAGCATTATGCCCCAAAAGAAAAACCCCGACGTACCGGAATTAG
TCAGGGGAAAAACTGGGCGTGTATTTGGTCATCTCCAAGCAATGTTGGTAATCATGAAAGGATTACCCTTGGCATATAAC
AAAGACCTGCAAGAAGACAAAGAAGGTTTATTTGACAGCGTTAACACAGTTAAGGCTTGTCTGGAAGCCATGACAATCTT
GCTACAGGAAGGCTTGGAATTTCGGACTCAGCGCCTAGCTGAAGCTGTCACACAAGATTTTTCTAACGCTACCGATGTCG
CAGATTATCTAGCAGCCAGGGGTGTTCCCTTCCGCGAAGCTTATAATATCGTGGGTAAAGTCGTTAAAACCAGTATTGCT
GCTGGCAAACTTTTAAAGGATTTAACCTTAGAAGAATGGCAACAAATACACCCAAAATTTGCCGACGATATTTATGAAGC
CATCTCCCCTCGTCAAGTTGTAGCTGCACGTAACAGTTACGGTGGTACTGGTTTTGCCCAGGTGAGTAAAGCCGTCAGCG
CGGCGCGTAAGGAAATTGGAGAATAG

Upstream 100 bases:

>100_bases
AATAACGATAAATAGTAAGCTGAAAGGTTAGGGAGCAGGAGAAAGAAAATTTACCCAATCCCCAGCCCCCAGTCCCCCAA
TCCCCAGTCCCCTTGTATTT

Downstream 100 bases:

>100_bases
GGGTGTAGGGGTTATTAGCGTACATCCAAACACAACTGACAACTGACAACTGACACGCAAAGCGGAATAAAAAACAAGGG
TGTACAAGACGTACACCCTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTEKQTWSQRFESALHPAIALFNASISFDIELIEYDLTGSQAHAQMLAHTGIISPAEGEQLVAGLEQIREEYRQGKFQPG
IDAEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDTRLYLRDQILQIKTQLREFQRVLLDIAEKNVETLIPGYTHLQ
RAQPVSLAHHLLAYFQMAQRDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLQFERIYENSLDGVSDRDFAIEF
LCAASLIMVHLSRLSEEIILWASEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGRVFGHLQAMLVIMKGLPLAYN
KDLQEDKEGLFDSVNTVKACLEAMTILLQEGLEFRTQRLAEAVTQDFSNATDVADYLAARGVPFREAYNIVGKVVKTSIA
AGKLLKDLTLEEWQQIHPKFADDIYEAISPRQVVAARNSYGGTGFAQVSKAVSAARKEIGE

Sequences:

>Translated_461_residues
MTEKQTWSQRFESALHPAIALFNASISFDIELIEYDLTGSQAHAQMLAHTGIISPAEGEQLVAGLEQIREEYRQGKFQPG
IDAEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDTRLYLRDQILQIKTQLREFQRVLLDIAEKNVETLIPGYTHLQ
RAQPVSLAHHLLAYFQMAQRDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLQFERIYENSLDGVSDRDFAIEF
LCAASLIMVHLSRLSEEIILWASEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGRVFGHLQAMLVIMKGLPLAYN
KDLQEDKEGLFDSVNTVKACLEAMTILLQEGLEFRTQRLAEAVTQDFSNATDVADYLAARGVPFREAYNIVGKVVKTSIA
AGKLLKDLTLEEWQQIHPKFADDIYEAISPRQVVAARNSYGGTGFAQVSKAVSAARKEIGE
>Mature_460_residues
TEKQTWSQRFESALHPAIALFNASISFDIELIEYDLTGSQAHAQMLAHTGIISPAEGEQLVAGLEQIREEYRQGKFQPGI
DAEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDTRLYLRDQILQIKTQLREFQRVLLDIAEKNVETLIPGYTHLQR
AQPVSLAHHLLAYFQMAQRDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLQFERIYENSLDGVSDRDFAIEFL
CAASLIMVHLSRLSEEIILWASEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGRVFGHLQAMLVIMKGLPLAYNK
DLQEDKEGLFDSVNTVKACLEAMTILLQEGLEFRTQRLAEAVTQDFSNATDVADYLAARGVPFREAYNIVGKVVKTSIAA
GKLLKDLTLEEWQQIHPKFADDIYEAISPRQVVAARNSYGGTGFAQVSKAVSAARKEIGE

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=450, Percent_Identity=43.5555555555556, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=450, Percent_Identity=43.5555555555556, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=450, Percent_Identity=41.1111111111111, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI68303547, Length=450, Percent_Identity=41.1111111111111, Blast_Score=340, Evalue=1e-93,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=47.032967032967, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=41.6122004357298, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=39.5604395604396, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=39.5604395604396, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51727; Mature: 51595

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00163 FUMARATE_LYASES ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKQTWSQRFESALHPAIALFNASISFDIELIEYDLTGSQAHAQMLAHTGIISPAEGEQ
CCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHH
LVAGLEQIREEYRQGKFQPGIDAEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDTR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LYLRDQILQIKTQLREFQRVLLDIAEKNVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHH
DWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLQFERIYENSLDGVSDRDFAIEF
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LCAASLIMVHLSRLSEEIILWASEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCH
VFGHLQAMLVIMKGLPLAYNKDLQEDKEGLFDSVNTVKACLEAMTILLQEGLEFRTQRLA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVTQDFSNATDVADYLAARGVPFREAYNIVGKVVKTSIAAGKLLKDLTLEEWQQIHPKF
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
ADDIYEAISPRQVVAARNSYGGTGFAQVSKAVSAARKEIGE
HHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKQTWSQRFESALHPAIALFNASISFDIELIEYDLTGSQAHAQMLAHTGIISPAEGEQ
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHH
LVAGLEQIREEYRQGKFQPGIDAEDVHFAVERRLTEIVGDVGKKLHTARSRNDQVGTDTR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LYLRDQILQIKTQLREFQRVLLDIAEKNVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHH
DWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLQFERIYENSLDGVSDRDFAIEF
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LCAASLIMVHLSRLSEEIILWASEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGR
HHHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCH
VFGHLQAMLVIMKGLPLAYNKDLQEDKEGLFDSVNTVKACLEAMTILLQEGLEFRTQRLA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAVTQDFSNATDVADYLAARGVPFREAYNIVGKVVKTSIAAGKLLKDLTLEEWQQIHPKF
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHH
ADDIYEAISPRQVVAARNSYGGTGFAQVSKAVSAARKEIGE
HHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA