Click here to switch to the map view.

The map label for this gene is moaA [H]

Identifier: 17231357

GI number: 17231357

Start: 4664915

End: 4665901

Strand: Reverse

Name: moaA [H]

Synonym: all3865

Alternate gene names: 17231357

Gene position: 4665901-4664915 (Counterclockwise)

Preceding gene: 17231358

Following gene: 17231354

Centisome position: 72.75

GC content: 46.2

Gene sequence:

>987_bases
ATGAACCAGGTAGACTACCTCCGTATTAGCTTAATAGATCGCTGCAATTTTCGTTGTCAGTACTGTATGCCAGAGGGGTC
AGAGCTAAACTATATCCTCAAGCAACAATTATTGACTGATGAGGAATTGCTCACTTTAGTTCAAGAAGTATTTATTCCTG
TTGGTTTTAGACAATTTCGGTTAACGGGGGGAGAGCCGTTACTGCGTCCCCACGTTGTGGATTTGGTGGGGGCGATCGCA
TCTTTACCCCAAACGCAAGACCTCTCCATGACTACCAACGGCTTTTTACTCGCACCCATCGCCCAAAATCTTTACGATGC
TGGTTTACGGCGGATCAATATCAGCTTAGATTCCCTTGATCCCCATATCTTTGATCAGATTATCGGCAGTCATGGACGCC
CTCGCTGGCAACAAGTTTGGGATGGTATTCAAGCTGCCCATCGTGTAGGTTTTGACCCATTGAAACTAAATGTAGTGGTA
ATTCCTGGTGTCAACGACCACGAAATTCTGGATTTAGCTGCCTTAAGCATCGATAAACAATGGCACGTCCGGTTTATTGA
ATTTATGCCCATTGGTAACGGAGAATTATTTGGCGATCGCGGTTGGGTATCTTCCGCCGAATTACGCCAGCAAATCCGCG
ATCGCTGGGGCTTGACAGATGCTCAAGTTCGTGGTGCTGGCCCGGCGGATGTTTTTCAAATCCCTGGTGCGAAAGGCACA
CTAGGATTTATCAGTCAGATGTCAGAGTGTTTTTGCGATCGTTGTAACCGGATGCGTCTCAGTGCCGATGGCTGGCTACG
TCCTTGCTTATTAAACGAAACAGGTCAACTCGATCTAAAAACATCTCTACGCTCTGGTGTAAGTATCCACCAGTTAAGAG
AACAGGTGAGACATTTATTAGCAATCAAACCAGAAATTAACTATAAAGGGCGCGATTCCGGGACTACAGGAGTCTACAGC
CGTACAATGTCACAAATTGGAGGTTAG

Upstream 100 bases:

>100_bases
AGCGTGCAGAGGTTGATGAAGAATCAAGTAGTAGAGAAATTGAGGTGAGGTTTCAAGCAGGGATCTATAACGATCGCTCA
CAATAGAAAATAAAACCCAG

Downstream 100 bases:

>100_bases
TCAGTTATCAGTCAACAGTCAACAGTCAACCCCATCTTTACGCAATACTACCTCGCTTCCTCGCTTCTTTGTAAGAAGTC
CCGACATTTTTCAACCCAGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNQVDYLRISLIDRCNFRCQYCMPEGSELNYILKQQLLTDEELLTLVQEVFIPVGFRQFRLTGGEPLLRPHVVDLVGAIA
SLPQTQDLSMTTNGFLLAPIAQNLYDAGLRRINISLDSLDPHIFDQIIGSHGRPRWQQVWDGIQAAHRVGFDPLKLNVVV
IPGVNDHEILDLAALSIDKQWHVRFIEFMPIGNGELFGDRGWVSSAELRQQIRDRWGLTDAQVRGAGPADVFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGVSIHQLREQVRHLLAIKPEINYKGRDSGTTGVYS
RTMSQIGG

Sequences:

>Translated_328_residues
MNQVDYLRISLIDRCNFRCQYCMPEGSELNYILKQQLLTDEELLTLVQEVFIPVGFRQFRLTGGEPLLRPHVVDLVGAIA
SLPQTQDLSMTTNGFLLAPIAQNLYDAGLRRINISLDSLDPHIFDQIIGSHGRPRWQQVWDGIQAAHRVGFDPLKLNVVV
IPGVNDHEILDLAALSIDKQWHVRFIEFMPIGNGELFGDRGWVSSAELRQQIRDRWGLTDAQVRGAGPADVFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGVSIHQLREQVRHLLAIKPEINYKGRDSGTTGVYS
RTMSQIGG
>Mature_328_residues
MNQVDYLRISLIDRCNFRCQYCMPEGSELNYILKQQLLTDEELLTLVQEVFIPVGFRQFRLTGGEPLLRPHVVDLVGAIA
SLPQTQDLSMTTNGFLLAPIAQNLYDAGLRRINISLDSLDPHIFDQIIGSHGRPRWQQVWDGIQAAHRVGFDPLKLNVVV
IPGVNDHEILDLAALSIDKQWHVRFIEFMPIGNGELFGDRGWVSSAELRQQIRDRWGLTDAQVRGAGPADVFQIPGAKGT
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGVSIHQLREQVRHLLAIKPEINYKGRDSGTTGVYS
RTMSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=291, Percent_Identity=42.9553264604811, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI22027536, Length=291, Percent_Identity=42.9553264604811, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1786999, Length=323, Percent_Identity=33.7461300309598, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=337, Percent_Identity=39.1691394658754, Blast_Score=210, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI32566331, Length=303, Percent_Identity=40.5940594059406, Blast_Score=208, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=336, Percent_Identity=39.2857142857143, Blast_Score=207, Evalue=6e-54,
Organism=Drosophila melanogaster, GI28574490, Length=292, Percent_Identity=40.4109589041096, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI28574488, Length=292, Percent_Identity=40.4109589041096, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36879; Mature: 36879

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVDYLRISLIDRCNFRCQYCMPEGSELNYILKQQLLTDEELLTLVQEVFIPVGFRQFR
CCCCCEEEEEEHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
LTGGEPLLRPHVVDLVGAIASLPQTQDLSMTTNGFLLAPIAQNLYDAGLRRINISLDSLD
ECCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEHHHHHHHHHCCCEEEEEEHHCCC
PHIFDQIIGSHGRPRWQQVWDGIQAAHRVGFDPLKLNVVVIPGVNDHEILDLAALSIDKQ
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCC
WHVRFIEFMPIGNGELFGDRGWVSSAELRQQIRDRWGLTDAQVRGAGPADVFQIPGAKGT
CEEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCCCH
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGVSIHQLREQVRHLL
HHHHHHHHHHHHHHHCCEEECCCCCCCCEECCCCCCEEEHHHHHCCCHHHHHHHHHHHHH
AIKPEINYKGRDSGTTGVYSRTMSQIGG
CCCCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNQVDYLRISLIDRCNFRCQYCMPEGSELNYILKQQLLTDEELLTLVQEVFIPVGFRQFR
CCCCCEEEEEEHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
LTGGEPLLRPHVVDLVGAIASLPQTQDLSMTTNGFLLAPIAQNLYDAGLRRINISLDSLD
ECCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEHHHHHHHHHCCCEEEEEEHHCCC
PHIFDQIIGSHGRPRWQQVWDGIQAAHRVGFDPLKLNVVVIPGVNDHEILDLAALSIDKQ
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCC
WHVRFIEFMPIGNGELFGDRGWVSSAELRQQIRDRWGLTDAQVRGAGPADVFQIPGAKGT
CEEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCCCH
LGFISQMSECFCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGVSIHQLREQVRHLL
HHHHHHHHHHHHHHHCCEEECCCCCCCCEECCCCCCEEEHHHHHCCCHHHHHHHHHHHHH
AIKPEINYKGRDSGTTGVYSRTMSQIGG
CCCCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA